 | | Vol. 12.35 – 7 September, 2023 |
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| Scientists established an organoid-based lung fibrosis model using mouse and human lung tissues to assess the direct communication between damaged alveolar type II (AT2)-lineage cells and lung fibroblasts by excluding immune cells.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that the expression of caveolin-1, tumor suppressor protein p53, and plasminogen activator inhibitor-1 were markedly increased in airway epithelial cells as well as in type II alveolar epithelial cells from the lungs of patients with COPD or wild-type mice with cigarette smoke-induced lung injury.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Researchers corroborated the effectiveness and significance of the traditional Chinese medications Astragalus and Danshen in idiopathic pulmonary fibrosis treatment.
[BMC Pulmonary Medicine] |
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| MiR-143-3p inhibited airway epithelial cell epithelial mesenchymal transition as well as lung fibroblast extracellular matrix production by downregulating Smad3.
[Pulmonary Pharmacology & Therapeutics] |
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| | The Cancer Genome Atlas data mining, NCBI/GEO data mining, and western blotting analysis were employed to characterize the expression of plant homologous structural domain finger protein 23 (PHF23) in NSCLC cell lines and tissues.
[Cell Death & Disease] |
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| Researchers demonstrated that palmitic acid or high-fat diet promoted lung adenocarcinoma (LUAD) cell proliferation and metastasis in a CD36-dependent manner.
[Cell Death & Disease] |
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| Investigators used both autochthonous and transplantable KRAS-mutant tumor models to investigate the role of tumor-derived CUL4B in KRAS-driven lung cancers. They showed that knockout or knockdown of CUL4B promoted lung adenocarcinoma growth and progression in both models.
[Oncogene] |
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| The lung adenocarcinoma (LUAD) cell line with a high expression of CYP4A22-AS1 was constructed to evaluate the role of CYP4A22-AS1 in the proliferation and metastasis of LUAD by CCK8, scratch healing, transwell assays, and animal experiments.
[Cancer Cell International] |
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| Scientists profiled the changes in gene expression according to the regulation of expression of MALAT1 in NSCLC cell lines and investigated the correlation through bioinformatic analysis of differentially expressed genes.
[BMC Cancer] |
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| The authors highlight the link between small ubiquitin-like modifier (SUMO) pathway and lung diseases, especially the sumoylated substrate such as C/EBPα in bronchopulmonary dysplasia, PPARγ in pneumonia, TFII-I in asthma, HDAC2 in COPD, and KLF15 in hypoxic pulmonary hypertension.
[Molecular Medicine] |
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| | Roche announced today that the Phase III ALINA study evaluating Alecensa® met its primary endpoint of disease-free survival at a prespecified interim analysis. Alecensa is an ALK inhibitor that demonstrates a reduction in the risk of disease recurrence or death for people with early-stage ALK-positive NSCLC.
[Roche] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | University of Nottingham – Nottingham, Scotland, United Kingdom |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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