Pulmonary Cell News Volume 12.37 | Sep 21 2023

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    2023-09-21 | PULCN 12.37


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.37 – 21 September, 2023
    TOP STORY

    Crystal Ribcage: A Platform for Probing Real-Time Lung Function at Cellular Resolution

    Researchers introduced the crystal ribcage: a transparent ribcage that allows multiscale optical imaging of the functioning lung from whole-organ to single-cell level.
    [Nature Methods]

    Abstract
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    Opposing Roles for TGFβ- and BMP-Signaling during Nascent Alveolar Differentiation in the Developing Human Lung

    Using lung explant and organoid models, scientists identified opposing effects of TGFβ- and BMP-signaling, where inhibition of TGFβ- and activation of BMP-signaling in the context of high WNT- and FGF-signaling efficiently differentiated early lung progenitors into alveolar type 2-like cells in vitro.
    [NPJ Regenerative Medicine]

    Full Article

    MPZL1 Suppresses the Cancer Stem-Like Properties of Lung Cancer through β-Catenin/TCF4 Signaling

    Scientists explored the influence of myelin protein zero-like protein 1 (MPZL1) on the stem-like properties of cancer cells and the underlying mechanism in lung adenocarcinoma.
    [Functional & Integrative Genomics]

    Abstract

    IL-13 Induced Inflammation Increases DPP4 Abundance but Does Not Enhance MERS-CoV Replication in Airway Epithelia

    Investigators modeled chronic airway disease by treating primary human airway epithelia with the Th2 cytokine IL-13, examining how this impacted dipeptidyl peptidase 4 (DPP4) protein levels along with Middle East respiratory syndrome coronavirus entry and replication.
    [Journal Of Infectious Diseases]

    Abstract

    Mechanism Underlying the Effect of MnO2 Nanosheets for A549 Cell Chemodynamic Therapy

    MnO2 nanosheets (MnO2NSs) were synthesized by a one-step method, and MnO2NSs were applied to A549 cell chemodynamic therapy. Researcgers found that A549 cells which were treated by MnO2NSs have 17 different metabolites and nine metabolic pathways that varied markedly.
    [Microchimica Acta]

    AbstractGraphical Abstract

    Exposure to Phagolysosomal Simulated Fluid Altered the Cytotoxicity of PET Micro(nano)plastics to Human Lung Epithelial Cells

    Scientists focused on exploring how the physicochemical differences of micro(nano)plastics under pH 4.5 phagolysosome conditions impact cytotoxicity and the oxidative characteristics of lung epithelial cells.
    [Toxicology Mechanisms And Methods]

    Abstract

    CXXC Finger Protein 1 (CFP1) Bridges the Reshaping of Genomic H3K4me3 Signature to the Advancement of Lung Adenocarcinoma

    Scientists unveiled that CFP1 promoted lung adenocarcinoma cell proliferation, migration, and invasion while impairing cell apoptosis through in vitro and in vivo models.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Critical Requirement of SOS1 for Tumor Development and Microenvironment Modulation in KRASG12D-Driven Lung Adenocarcinoma

    The impact of genetic ablation of SOS1 or SOS2 was evaluated in a murine model of KRASG12D-driven lung adenocarcinoma.
    [Nature Communications]

    Full Article

    Activation of PI3K/Akt Pathway by G Protein-Coupled Receptor 37 Promotes Resistance to Cisplatin-Induced Apoptosis in Non-Small Cell Lung Cancer

    Investigators explored the expression and prognosis of GPR37 in NSCLC through TCGA, GTEx, GEO, and GEPIA2. They detected the expression of GPR37 in NSCLC tissues and cell lines.
    [Cancer Medicine]

    Full Article
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    REVIEWS

    Beyond Epithelial Damage: Vascular and Endothelial Contributions to Idiopathic Pulmonary Fibrosis

    The authors propose that vascular and endothelial cell abnormalities are both causal and consequential in the pathobiology of idiopathic pulmonary fibrosis and that fuller evaluation of dysregulated pathways may lead to effective therapies and a cure for this devastating disease.
    [Journal Of Clinical Investigation]

    Full Article
    INDUSTRY AND POLICY NEWS

    Corsair Pharma Announces $23 Million Series B Financing to Advance Clinical Trials in Pulmonary Arterial Hypertension

    Corsair Pharma, Inc. announced the closing of its $23M Series B financing led by New Rhein Healthcare Investors. Proceeds from the financing will support the clinical advancement of a prodrug of treprostinil delivered in a proprietary transdermal patch to treat Pulmonary Arterial Hypertension.
    [Corsair Pharma, Inc.]

    Press Release
    FEATURED EVENT

    SIOP 2023 Congress

    October 11 – 14, 2023
    Ottawa, Ontario, Canada

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Pediatric Pulmonary

    Baylor College of Medicine – Houston, Texas, United States

    Research Positions – Pluripotent Stem Cell, Lung Differentiation, and Genomics

    The University of British Columbia – Vancouver, British Columbia, Canada

    Clinical / Non-Clinical Senior Lecturer – Experimental Medicine

    King’s College London – London, England, United Kingdom

    Senior Scientist – Pulmonary & Critical Care Medicine

    University of Washington – Medical Lake, Washington, United States

    Faculty Positions – Cancer Metastasis

    The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States

    > See All Jobs

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