 | | Vol. 12.38 – 28 September, 2023 |
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| Coxsackievirus B5/Faulkner was screened for its potential oncolytic effect against NSCLCs through inducing apoptosis and autophagy.
[Signal Transduction And Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that human keratin (KRT) 8 genetic variants were associated with idiopathic pulmonary fibrosis. Krt8-/- mice were protected from fibrosis and accumulation of the transitional state. Keratin 8 regulated the expression of macrophage chemokines and macrophage recruitment.
[Journal Of Clinical Investigation] |
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| Researchers revealed a potential mechanism by which KRT5+ cells migrate within the fibrotic lung, navigating regional differences in collagen topography. In vitro, KRT5+ cell migratory characteristics and expression of remodeling genes were modulated by extracellular matrix composition and organization.
[Nature Communications] |
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| Investigators showed that ovarian tumor family deubiquitinase 4 (OTUD4) protein reduced in cigarette smoke extract (CSE) treated mice and airway epithelial cells. OTUD4 silence aggravated cell apoptosis and emphysematous change in the lung tissue of CSE treated mice.
[Cell Death & Disease] |
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| Scientists investigated the efficacy of Trigonella foenum-graecum Linné in a bronchial cell model and an animal model of asthma exacerbation caused by particulate matter (PM). BEAS-2B bronchial epithelial cells were simultaneously treated with tumor necrosis factor-α/interleukin-4 and PM.
[Journal Of Ethnopharmacology] |
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| Porcine and human tracheal and bronchial epithelial cells are compared in terms of in vivo tissue architecture and in vitro cell behavior under standard and airlifted conditions, analyzing the regenerative, proliferative, and differentiative potentials of these cells.
[Scientific Reports] |
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| Scientists investigated the potential mechanism of early growth response factor (EGR-1)-mediated regulation of epithelial sodium channel in acute lung injury (ALI). They explored whether EGR-1 aggravates the pulmonary edema response in acute lung injury.
[Immunological Investigations] |
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| Researchers found that loss of YAP expression was key for SCLC cells to acquire rapid ameboid migration and high metastatic potential. YAP functioned through its target genes CCN1/CCN2 to inhibit SCLC ameboid migration.
[Nature Communications] |
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| Investigators identified and validated the key differentially expressed immune-related genes regulated by the miR-200 family which may serve for therapeutic aspects in LUAD tumor microenvironment by affecting cancer progression, invasion, and metastasis.
[Scientific Reports] |
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| The authors present the latest preclinical achievements of stem cell therapies, focusing on the therapeutic effects of clinical trials and discussing the challenges and future perspectives of large-scale applications.
[European Respiratory Review] |
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| Genprex Inc. was granted FDA orphan drug designation for its REQORSA(R) immunogene therapy in development for the treatment of SCLC.
[Genprex, Inc.] |
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| After viewing Roche’s U.K. resources website for Rozlytrek, a drug used to treat ROS1-positive NSCLC and NTRK fusion-positive solid tumors, an anonymous person complained to the Prescription Medicines Code of Practice Authority that the content was misleading.
[Fierce Biotech] |
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| October 29 – November 1, 2023
New York, New York, United States |
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| | Indiana University – Indiana, Pennsylvania, United States |
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| | Stanford University – Stanford, California, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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