Pulmonary Cell News Volume 12.39 | Oct 05 2023

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    2023-10-05 | PULCN 12.39


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.39 – 5 October, 2023
    TOP STORY

    Oxidized IL-33 Drives COPD Epithelial Pathogenesis via ST2-Independent RAGE/EGFR Signaling Complex

    In vitro epithelial damage assays and three-dimensional, air–liquid interface cell culture models of healthy and COPD epithelia were used to elucidate the functional role of IL-33ox.
    [European Respiratory Journal]

    Full ArticleGraphical Abstract
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    Src and TKS5 Mediated Podosome Formation in Fibroblasts Promotes Extracellular Matrix Invasion and Pulmonary Fibrosis

    Increased expression of TKS5, a scaffold protein essential for the formation of podosomes, was detected in the lung tissue of Idiopathic Pulmonary Fibrosis patients and bleomycin-treated mice.
    [Nature Communications]

    Full Article

    Exogenous Ang-(1–7) Inhibits Autophagy via HIF-1α/THBS1/BECN1 Axis to Alleviate Chronic Intermittent Hypoxia-Enhanced Airway Remodelling of Asthma

    Scientists explored how chronic intermittent hypoxia aggravated asthma and the mechanism of protective effects of Ang-(1-7) on airway remodeling, with a focus on autophagy.
    [Cell Death Discovery]

    Full Article

    Excretory/Secretory Products from Schistosoma japonicum Eggs Alleviate Ovalbumin-Induced Allergic Airway Inflammation

    Researchers investigated the protective effects of excretory/secretory products from Schistosoma japonicum eggs on asthmatic inflammation. They established an allergic airway inflammation model in mice by alum-adjuvanted ovalbumin sensitization and challenge.
    [PLOS Neglected Tropical Diseases]

    Full Article

    Circ_0026579 Knockdown Ameliorates Lipopolysaccharide-Induced Human Lung Fibroblast Cell Injury by Regulating CXCR1 via miR-370-3p

    Investigators revealed the role of circ_0026579 in lipopolysaccharide-induced human lung fibroblast cell injury and the underlying mechanism.
    [Clinical And Experimental Pharmacology And Physiology]

    Abstract

    Propionate Reinforces Epithelial Identity and Reduces Aggressiveness of Lung Carcinoma

    Scientists used an epithelial-to-mesenchymal transition (EMT)-focused integrative functional genomic approach and identified an inverse association between short-chain fatty acids and EMT in NSCLC patients.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Oncogenic KRAS Mutation Confers Chemoresistance by Upregulating SIRT1 in Non-Small Cell Lung Cancer

    Investigators demonstrated that the mRNA and protein levels of the class III histone deacetylase SIRT1 were upregulated by the kirsten rat sarcoma viral oncogene homologue (KRAS)Mut-Raf-MEK-c-Myc axis in KRASMut lung cancer cells and in lung tumors of a mouse model with spontaneous KrasG12D expression.
    [Experimental & Molecular Medicine]

    Full Article

    Crotonylated BEX2 Interacts with NDP52 and Enhances Mitophagy to Modulate Chemotherapeutic Agent-Induced Apoptosis in Non-Small-Cell Lung Cancer Cells

    Researchers reported that crotonylated brain expressed X-linked gene 2 (BEX2) played an important role in inhibiting chemotherapeutic agent-induced apoptosis via enhancing mitophagy in human lung cancer cells.
    [Cell Death & Disease]

    Full Article

    CSE1L Is a Negative Regulator of the RB-DREAM Pathway in p53 Wild-Type NSCLC and Can Be Targeted Using an HDAC1/2 Inhibitor

    Scientists identified CSE1L as a novel inhibitor of the RBL2-DREAM pathway and target to activate RBL2-DREAM in NSCLC cells. CSE1L is an oncoprotein that maintains repression of genes that could be reactivated by HDAC inhibitors.
    [Scientific Reports]

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    REVIEWS

    What Role Will Ensifentrine Play in the Future Treatment of Chronic Obstructive Pulmonary Disease Patients? Implications from Recent Clinical Trials

    Two recent Phase III studies, ENHANCE-1 and ENHANCE-2, have shown that it induces significant bronchodilation and reduces the risk of COPD worsening, exerting an anti-inflammatory effect. Data from the ENHANCE studies also showed the benefit of adding ensifentrine to treatment with bronchodilators.
    [Immunotherapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    BiomX Announces Completion of Patient Dosing in Part 2 of the Phase Ib/IIa Study Evaluating BX004 for Treatment of Chronic Pulmonary Infections in Patients with Cystic Fibrosis

    BiomX, Inc. announced the completion of patient dosing in Part 2 of the Phase Ib/IIa trial evaluating their novel phage cocktail, BX004, for the treatment of chronic pulmonary infections caused by Pseudomonas aeruginosa in patients with cystic fibrosis.
    [BiomX, Inc.]

    Press Release
    FEATURED EVENT

    Generation and Application of Organoid Disease Models

    October 29 – November 3, 2023
    Hinxton, England, United Kingdom

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    JOB OPPORTUNITIES

    Academic Physician – Sleep Medicine and/or COPD

    University of Alberta – Edmonton, Alberta, Canada

    Assistant/Associate Professor – Pulmonary Medicine

    Indiana University – Indiana, Pennsylvania, United States

    Postdoctoral Position – Mucosal Immunity

    Stanford University – Stanford, California, United States

    Faculty Positions – Cancer Research

    Houston Methodist Research Institute – Houston, Texas, United States

    Postdoctoral Associate – NMR-based Metabolomics and Metabolomic Imaging

    Massachusetts General Hospital – Boston, Massachusetts, United States

    > See All Jobs

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