| Vol. 12.41 – 19 October, 2023 |
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| A microfluidic organ-on-a-chip lined by human lung alveolar epithelium interfaced with pulmonary endothelium was used to model acute radiation-induced lung injury in vitro. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators evaluated the potential role of circulating extracellular vesicles (EVs) from COPD subjects in lung cancer onset. Plasma-EVs were isolated by ultracentrifugation from heavy smoker volunteers with or without heavy smoker-EVs, and COPD and characterized following MISEV guidelines. [Cell Death & Disease] |
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| Scientists determined whether a smaller lung volume or a stiffer lung tissue accounts for the greater lung elastance of C57BL/6 than BALB/c mice. [Scientific Reports] |
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| Alveolar-like tissue was reconstructed in a microfluidic device with human microvascular lung endothelial cells cultured under flow-induced shear stress and human epithelial cells cultured at air–liquid interface. [Biomedical Microdevices] |
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| | Researchers showed that the reduced JmjC domain-containing 5 (JMJD5) expression was negatively associated with epidermal growth factor receptor stability and NSCLC progression. [Cell Death & Disease] |
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| Investigators explored the metabolic rewiring behind radioresistance and found therapeutic approaches to overcome radioresistance. Pharmacological inhibition of PI3K/AKT/mTOR signaling improved the effectiveness of radiotherapy, including inhibiting cell proliferation and increasing cell apoptosis. [Cell Death & Disease] |
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| Scientists reported that D-mannose up-regulated lysosomal activity by enhancing TFE3-mediated lysosomal biogenesis, thereby increasing the degradation of epidermal growth factor receptor (EGFR) and significantly down-regulating its protein level. [Oncogene] |
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| Investigators demonstrated that centrosomal protein 20 (CEP20) was upregulated in NSCLC tissues and associated with cancer invasion metastasis. Notably, CEP20 depletion inhibited NSCLC cell proliferation, migration, and microtubule polymerization. [Scientific Reports] |
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| Researchers investigated the molecular mechanisms underlying the inhibitory effects of isothiocyanates on cancer cell metastasis. [Acta Pharmacologica Sinica] |
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| The authors review emerging hypotheses that explain how the lung repairs itself after injury and why these mechanisms of lung repair fail in some individuals, particularly the elderly. [Journal Of Clinical Investigation] |
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| Merck announced that the European Commission has approved KEYTRUDA, Merck’s anti-PD-1 therapy, as a monotherapy for the adjuvant treatment of adults with NSCLC who are at high risk of recurrence following complete resection and platinum-based chemotherapy. [MERCK] |
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| Andrew A. Wilson, MD, of Boston University (BU) Chobanian & Avedisian School of Medicine, has recently received a gift of $100,000 to establish the Katharine Howe Lovett Fund for Alpha-1 antitrypsin deficiency (AATD) Research. [Boston University] |
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| November 15 – 17, 2023 Seoul, Korea |
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| University of Alabama at Biringham – Birmingham, Alabama, United States |
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| University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| Institut Necker Enfants-Malades – Paris, France |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| University of Alberta – Edmonton, Alberta, Canada |
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