 | | Vol. 12.42 – 26 October, 2023 |
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| Using a type II alveolar epithelial cell-specific Sohlh2 conditional knock-in mouse model, researchers found that Sohlh2, a basic HLH transcription factor, accelerated age-related pulmonary fibrosis.
[Cell Death & Disease] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Cellular senescence increased in rat and human bronchopulmonary dysplasia lungs, as evidenced by increased oxidative DNA damage, tumor suppressors, GL-13 stain, and inflammatory cytokines with decreased cell proliferation and lamin B expression.
[American Journal Of Respiratory Cell And Molecular Biology] |
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| Using airway epithelial cell lines and primary small airway epithelial cells from healthy and asthma-diseased donors, investigators showed that β2AR agonism generated H2O2 in a receptor and NAPDH oxidase-dependent manner.
[Biomedicine & Pharmacotherapy] |
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| Scientists explored the mechanisms of ZC3H4 by which to stimulate epithelial cell migration. Pathological analysis and 2D migration assay were established to uncover the pulmonary fibrotic lesions and epithelial cell migration, respectively.
[Environmental Toxicology And Pharmacology] |
| | Researchers demonstrated that bone marrow-derived mesenchymal stem cells prevented and ameliorated acute lung injury by inhibiting Caspase-3-GSDME-mediated pyroptosis of lung epithelial cells as well as hypercytokinemia.
[European Journal Of Pharmacology] |
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| Investigators analyzed tissue samples isolated from patients with lung adenocarcinoma (LUAD) at early stages and used imaging-based biomarkers to predict LUAD behavior.
[Scientific Reports] |
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| Researchers explored whether methyltransferase like 3 (METTL3) in cancer associated fibroblasts (CAFs) affected the secretion of IL-18, which drove NSCLC cells to regulate PD-L1-mediated immunosuppression via the nuclear factor kappa B (NF-κB) pathway.
[Epigenetics] |
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| Uroplakin1B (UPK1B) was overexpressed or knocked down in the NSCLCs were. The proliferation and invasion of those cells were detected with the EdU staining and transwell assays.
[Tissue And Cell] |
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| Investigators assessed commonly used viability assays in clinically relevant human mesenchymal/stromal stem cells and human A549 lung carcinoma cells.
[Journal Of Pharmacological And Toxicological Methods] |
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| The authors focus on the recent advances in the molecular knowledge of SCLC and potential promising new treatment strategies, like targeting the DNA damage pathway, epigenetics, angiogenesis, and oncogenic drivers.
[Current Oncology Reports] |
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| Bolt Biotherapeutics announced that the first patient has been dosed with BDC-3042 in the single-agent dose-escalation portion of this first-in-human Phase I/II clinical study. They evaluated BDC-3042 in patients with metastatic or unresectable cancers including triple-negative breast cancer, colorectal cancer, NSCLC.
[Bolt Biotherapeutics] |
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| The study results showed that Alecensa® reduced the risk of disease recurrence or death by 76% compared with platinum-based chemotherapy in people with completely resected stage IB to IIIA ALK-positive NSCLC.
[Roche] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Yale University – New Haven, Connecticut, United States |
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| | University of Alabama at Biringham – Birmingham, Alabama, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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