Scientists demonstrated that unmodified red blood cell-derived extracellular vesicles could inhibit SARS-CoV-2 infection in a phosphatidylserine-dependent manner. [ACS Nano]
Researchers utilized transcriptomic and proteomic profiling to compare individuals who received two doses of Ad26.COV2.S with those vaccinated with BNT162b2 or mRNA-1273. [Nature Communications]
Investigators reported the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens. [Nature Communications]
This prospective cohort aimed to assess body composition, cardiopulmonary fitness, and long-term symptoms of overweight individuals affected by COVID-19. Participants were divided into three groups according to the severity of acute COVID-19: mild, moderate, and severe/critical cases. [Scientific Reports]
Researchers identified biological processes and pathways involved in various diseases which were most likely affected by COVID-19. [Microbial Pathogenesis]
Researchers depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all CD8α+ cells significantly impaired early control of Mycobacterium tuberculosis infection, leading to increased granulomas, lung inflammation, and bacterial burden. [Journal Of Experimental Medicine]
Researchers identified a critical window of CD4+ T cell responses that were targeted by IL-27. Neutralization of IL-27 during acute infection with Plasmodium chabaudi expanded specific CD4+ T cells, which were maintained at high levels thereafter. [EMBO Molecular Medicine]
Scientists studied the differential expression of multiple human endogenous retroviruses (HERVs) families in the presence of HIV infection in the peripheral blood mononuclear cells of HIV-positive individuals, in HIV-infected cell lines, and in vitro HIV-infected macrophages/monocytes of healthy donors. [Microbiology Spectrum]
Investigators evaluated the combined effect of the pro-apoptotic protein rhTRAIL with the replication-competent wild-type HSV-1 virus in head and neck cancer cell lines. [Scientific Reports]
Scientists summarize the role of NF-κB activation during SARS-CoV-2 invasion and replication, particularly the angiotensin-converting enzyme 2-mediated NF-κB activation. [Hypertension Research]
The authors review strategies in hepatitis B virus (HBV) prevention among people living with HIV, focusing specifically on updates in HBV vaccination and chemoprophylaxis. [Current HIV/Aids Reports]
Six months after announcing the $5 billion Project NextGen to develop treatments and vaccines that can “stay ahead of COVID-19,” the US government has awarded 20 contracts that reveal what much of that sum will support. [Science]
Molnupiravir, an antiviral drug used to treat COVID-19, induces numerous mutations in the SARS-CoV-2 genome that can increase the rate at which the virus evolves — yielding viral variants that might survive and be passed on. [Nature]
Using a type II alveolar epithelial cell-specific Sohlh2 conditional knock-in mouse model, researchers found that Sohlh2, a basic HLH transcription factor, accelerated age-related pulmonary fibrosis. [Cell Death & Disease]
Cellular senescence increased in rat and human bronchopulmonary dysplasia lungs, as evidenced by increased oxidative DNA damage, tumor suppressors, GL-13 stain, and inflammatory cytokines with decreased cell proliferation and lamin B expression. [American Journal Of Respiratory Cell And Molecular Biology]
Using airway epithelial cell lines and primary small airway epithelial cells from healthy and asthma-diseased donors, investigators showed that β2AR agonism generated H2O2 in a receptor and NAPDH oxidase-dependent manner. [Biomedicine & Pharmacotherapy]
Scientists explored the mechanisms of ZC3H4 by which to stimulate epithelial cell migration. Pathological analysis and 2D migration assay were established to uncover the pulmonary fibrotic lesions and epithelial cell migration, respectively. [Environmental Toxicology And Pharmacology]
Researchers demonstrated that bone marrow-derived mesenchymal stem cells prevented and ameliorated acute lung injury by inhibiting Caspase-3-GSDME-mediated pyroptosis of lung epithelial cells as well as hypercytokinemia. [European Journal Of Pharmacology]
Investigators analyzed tissue samples isolated from patients with lung adenocarcinoma (LUAD) at early stages and used imaging-based biomarkers to predict LUAD behavior. [Scientific Reports]
Researchers explored whether methyltransferase like 3 (METTL3) in cancer associated fibroblasts (CAFs) affected the secretion of IL-18, which drove NSCLC cells to regulate PD-L1-mediated immunosuppression via the nuclear factor kappa B (NF-κB) pathway. [Epigenetics]
Uroplakin1B (UPK1B) was overexpressed or knocked down in the NSCLCs were. The proliferation and invasion of those cells were detected with the EdU staining and transwell assays. [Tissue And Cell]
Investigators assessed commonly used viability assays in clinically relevant human mesenchymal/stromal stem cells and human A549 lung carcinoma cells. [Journal Of Pharmacological And Toxicological Methods]
The authors focus on the recent advances in the molecular knowledge of SCLC and potential promising new treatment strategies, like targeting the DNA damage pathway, epigenetics, angiogenesis, and oncogenic drivers. [Current Oncology Reports]
Bolt Biotherapeutics announced that the first patient has been dosed with BDC-3042 in the single-agent dose-escalation portion of this first-in-human Phase I/II clinical study. They evaluated BDC-3042 in patients with metastatic or unresectable cancers including triple-negative breast cancer, colorectal cancer, NSCLC. [Bolt Biotherapeutics]
The study results showed that Alecensa® reduced the risk of disease recurrence or death by 76% compared with platinum-based chemotherapy in people with completely resected stage IB to IIIA ALK-positive NSCLC. [Roche]
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