 | | Vol. 12.43 – 2 November, 2023 |
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| Researchers proposed that dynamic allosteric domain-domain communications not only regulated ATP-binding cassette C-transporters function, but were indispensable to tune the folding landscape of their posttranslational intermediates.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In a 3D organoid model, injured PDGFRα+ fibroblast-supported organoids were morphologically distinct from those cultured with normal fibroblasts, and scRNA-Seq analysis suggested distinct transcriptomic changes in alveolar epithelia supported by injured PDGFRα+ fibroblasts.
[JCI Insight] |
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| The in vitro activity of imipenem/relebactam and imipenem was compared with other antipseudomonal antibiotics against 105 isolates from patients with CF from three US hospitals.
[Antimicrobial Agents and Chemotherapy] |
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| The malignant behaviors of NSCLC cells were evaluated by CCK-8, colony formation, EdU, wound healing, and transwell assays.
[Cancer Gene Therapy] |
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| Investigators explored whether intrinsic differences between nasal and bronchial epithelial cells persisted in cell cultures and affected epithelial cell functioning in CF.
[Scientific Reports] |
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| | The authors reported an innovative design of a cationic lipid- and hyaluronic acid–based, dual-targeted mRNA nanoformulation that could display the desirable stability and efficiently transfect the targeted proteins into lung tissues.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists reported that the YTHDC1-mediated m6A epigenetic regulation of FSP1 alleviated the FSP1-dependent ferroptosis suppression that partially contributed to the tumor suppressive role of YTHDC1 in lung cancer progression.
[Cell Death & Differentiation] |
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| Researchers retrospectively analyzed 1011 lung cancer patients whose tumor samples were successfully profiled by high-throughput sequencing panel including genomic instability/homologous recombination deficiency score.
[npj Precision Oncology] |
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| The Cancer Genome Atlas database and spatial transcriptomics datasets from 10 × Genomics were used to analyze TRPV1 expression in various tumor tissues.
[Cellular Oncology] |
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| The authors provide a brief summary on the clinical relevance of recent research findings, which could soon pave the way towards a more personalized and targeted management of SCLC patients.
[Current Opinion In Oncology] |
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| Investigators discuss the current advances in neoantigen vaccines for treating cancers and then review the results of preclinical studies and early-phase human clinical trials of neoantigen-based therapies for NSCLC.
[Thoracic Cancer] |
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| University of Southern California (USC) faculty members Adam Leventhal, PhD and Caryn Lerman, PhD have received a $20 million grant for research to inform government regulations overseeing tobacco and its marketing, with a focus on protecting young people.
[University of Southern California] |
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| LUNGevity Foundation continues its multifaceted investment in the thoracic oncology workforce by announcing the recipients of four awards.
[LUNGevity Foundation] |
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| December 1 – 3, 2023
Chicago, Illinois, United States |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | National Jewish Health – Denver, Colorado, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | Karolinska Institutet – Solna, Sweden |
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