Pulmonary Cell News Volume 12.44 | Nov 9 2023

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    Laurisa Dohm
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    2023-11-09 | PULCN 12.44


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 14.44 – 9 November, 2023
    TOP STORY

    Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

    Using genetically engineered mouse models, patient-derived xenografts, and patient samples investigators found inhibition of KRAS promoted transition to a quiescent AT1-like cancer cell state in lung adenocarcinoma tumors.
    [Cancer Discovery]

    Abstract
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Fibroblast Growth Factor 10 Reverses Cigarette Smoke- and Elastase-Induced Emphysema and Pulmonary Hypertension in Mice

    Researchers analysed fibroblast growth factor 10 signaling in human lung sections and isolated cells from healthy donor, smoker, and COPD lungs.
    [European Respiratory Journal]

    Abstract

    SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs

    Scientists exploited tissue-optimized ribosome profiling and severe-COVID-19 model mice to establish the first temporal translation profiles of virus and host genes in the lungs during SARS-CoV-2 pathogenesis.
    [Experimental & Molecular Medicine]

    Full Article

    Crosstalk with Lung Fibroblasts Shapes the Growth and Therapeutic Response of Mesothelioma Cells

    Using co-cultures of patient-derived mesothelioma cell lines and lung fibroblasts, investigators demonstrated that fibroblast activation was a self-propagated process producing a fibrotic extracellular matrix and triggering drug resistance in mesothelioma cells.
    [Cell Death & Differentiation]

    Full Article

    3D Airway Epithelial–Fibroblast Biomimetic Microfluidic Platform to Unravel Engineered Nanoparticle-Induced Acute Stress Responses as Exposome Determinants

    The authors employed a 3D biomimetic microfluidic lung-on-chip platform and RNA-sequencing to examine the effects of two model anthropogenic engineered nanoparticles.
    [Environmental Science & Technology]

    AbstractGraphical Abstract

    Targeting the COMMD4–H2B Protein Complex in Lung Cancer

    Molecular modeling, in vitro binding, and site-directed mutagenesis were used to identify the copper metabolism gene MURR1 domain (COMMD) 4-H2B binding pose and develop a H2B peptide to inhibit the COMMD4-H2B interaction.
    [British Journal of Cancer]

    Full Article

    Glucose Deprivation Promotes Pseudo-Hypoxia and De-Differentiation in Lung Adenocarcinoma

    The authors tudied the mechanisms of resistance to glucose metabolism-targeting treatments, and found that glucose restriction in lung adenocarcinoma and other tumors induced cancer cell de-differentiation, leading to a more aggressive phenotype.
    [Cancer Research]

    Abstract

    Spatial Metabolomics Identifies Distinct Tumor-Specific and Stroma-Specific Subtypes in Patients with Lung Squamous Cell Carcinoma

    Combining high-mass-resolution imaging mass spectrometry with consensus clustering, four tumor- and four stroma-specific subtypes with distinct metabolite patterns were identified in 330 lung squamous cell carcinoma patients.
    [npj Precision Oncology]

    Full Article

    Targeting the Up-Regulated CNOT3 Reverses Therapeutic Resistance and Metastatic Progression of EGFR-Mutant Non-Small Cell Lung Cancer

    Scientists found that in lung cancer cells, the expression of CNOT3 could be regulated by epidermal growth factor receptor (EGFR) signaling pathway and c-Jun transcriptionally regulated its expression.
    [Cell Death Discovery]

    Full Article
    Watch this webinar to learn the advantages of using primary human nasal epithelial cells to study Cystic Fibrosis.
    REVIEWS

    Pyroptosis, Apoptosis, Necroptosis and Endoplasmic Reticulum Stress in Pulmonary Hypertension

    The authors investigate processes such as cellular pyroptosis, examine the intricate crosstalk between bone morphogenetic protein receptor type 2 mutations and the immune response, and shed light on key signaling pathways involved in the inflammatory response in the context of pulmonary hypertension.
    [Journal Of Advanced Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    Mirati Therapeutics Receives Approval from the MHRA for KRAZATI (adagrasib) as a Targeted Treatment Option for Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) with a KRASG12C Mutation

    The UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) granted conditional marketing authorization approval for KRAZATI® as a monotherapy indicated for the treatment of adult patients with advanced NSCLC with KRASG12C mutation, under specific circumstances.
    [Mirati Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    Cell Bio 2023

    December 2 – 6, 2023
    Boston, Massachusetts, United States

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    JOB OPPORTUNITIES

    Junior Group Leader – Cancer Research

    University of Cambridge – Cambridge, England, United Kingdom

    Tenure Track Faculty – Cancer and Cellular Biology

    Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Research Associate – Genetics and Genomics of Lung Disease

    National Jewish Health – Denver, Colorado, United States

    Project Scientist – Mechanisms of Lung Injury and Repair

    Cedars-Sinai – Los Angeles, California, United States

    Researcher – Cystic Fibrosis

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    > See All Jobs

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