Pulmonary Cell News Volume 12.48 | Dec 7 2023

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    2023-12-07 | PULCN 12.48


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.48 – 7 December, 2023
    TOP STORY

    The Role of APOBEC3B in Lung Tumor Evolution and Targeted Cancer Therapy Resistance

    Scientists studied the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B on epidermal growth factor receptor-driven lung cancer.
    [Nature Genetics]

    Full Article
    Learn more about using human primary cells for your assays
    PUBLICATIONSRanked by the impact factor of the journal

    Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo

    Following intratracheal aerosol delivery of Cy5-labeled peptide in rhesus macaques, the authors confirmed delivery throughout the respiratory tract.
    [Nature Communications]

    Full Article

    Dynamic RBM47 ISGylation Confers Broad Immunoprotection against Lung Injury and Tumorigenesis via TSC22D3 Downregulation

    K329R knockin mice with defective RBM47-ISGylation displayed heightened susceptibility to LPS-induced acute lung injury and lung tumorigenesis.
    [Cell Death Discovery]

    Full Article

    Understanding the Pathogenesis of Engineered Stone-Associated Silicosis: The Effect of Particle Chemistry on the Lung Cell Response

    Human alveolar epithelial cells and macrophages were exposed in vitro to dust and assessed for cytotoxicity and inflammation.
    [Respirology]

    Full Article

    Ang-(1–7)/Mas Axis Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice via Restoration of Nox4-Nrf2 Redox Homeostasis

    The angiotensin (Ang)-(1–7)-/Mas axis inhibited TGF-β1-induced lung fibroblast differentiation, inflammation, and fibrosis in bleomycin-treated lung tissue.
    [European Journal Of Pharmacology]

    Full Article

    Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model

    The authors investigated the biological effects of chemically characterized indoor dust extracts using three-dimensional lung cancer cell cultures combining phenotypic and lipidomic analyses.
    [Environmental Science & Technology]

    Full ArticleGraphical Abstract

    Oncogenic KRAS Effector USP13 Promotes Metastasis in Non-Small Cell Lung Cancer through Deubiquitinating β-Catenin

    Elevated USP13 promoted KRAS-mutant NSCLC metastasis, which was associated with poor prognosis in NSCLC patients.
    [Cell Reports]

    Full ArticleGraphical Abstract

    MiR-1246b, a Novel miRNA Molecule of Extracellular Vesicles in Bronchoalveolar Lavage Fluid, Promotes Nodule Growth through FGF14 in Patients with Lung Cancer

    The binding targets and underlying mechanisms of the differentially expressed miRNAs were verified by in vitro and in vivo experiments.
    [Cell Death & Disease]

    Full Article

    Semisynthesis of 5-O-Ester Derivatives of Renieramycin T and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines

    The in vitro cytotoxicity of the 17 semisynthesized derivatives of renieramycin S against human NSCLC cells in parallel with normal cell lines was evaluated.
    [Scientific Reports]

    Full Article

    Request a free copy of this wallchart for an overview of the different types of pluripotent cells
    REVIEWS

    Extracellular Vesicles in Venous Thromboembolism and Pulmonary Hypertension

    The roles and importance of extracellular vesicles substantially differs between studies, depending on experimental conditions and parent cell origins of extracellular vesicles that modify the nature of their cargo.
    [Journal Of Nanobiotechnology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Merus Shares Dip As Interim Lung Cancer Data Reveal Three Patient Deaths

    The therapy is a bispecific antibody targeting EGFR and c-MET, which are believed to be dysregulated in many tumors such as NSCLC.
    [Fierce Biotech]

    Editorial
    FEATURED EVENT

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    January 22 – 25, 2024
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    JOB OPPORTUNITIES

    Research Associate – Lung Fibrosis

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Fellowship – Pulmonary Fibrosis

    University of California, San Francisco – San Francisco, California, United States

    Postdoctoral Fellow – Pulmonary Medicine

    Indiana University – Indiana, Pennsylvania, United States

    Postdoctoral Scientist – Host-Pathogen Interactions in the Human Lung

    Rutgers Health – Newark, New Jersey, United States

    Postdoctoral Fellow – iPSC Lung Disease Models

    Royal College of Surgeons in Ireland – Dulin, Ireland

    > See All Jobs

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