Pulmonary Cell News Volume 13.03 | Jan 25 2024

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    Laurisa Dohm
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    2024-01-25 | PULCN 13.03


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.03 – 25 January, 2024
    TOP STORY

    EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth

    Elevated surfactant and GM-CSF secretion from the transformed epithelium induced tumor-associated alveolar macrophage proliferation which supported tumor growth by rewiring inflammatory functions and lipid metabolism.
    [Cancer Discovery]

    Abstract
    Grow Functional Airway Organoids with PneumaCult™
    PUBLICATIONSRanked by the impact factor of the journal

    Pharmacological Improvement of CFTR Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis

    Single cell transcriptomics revealed an impaired interferon signaling and reduced expression of MHC I and II encoding genes in epithelial cells of cyctic fibrosis children at baseline, which was partially restored by elexacaftor/tezacaftor/ivacaftor.
    [American Journal Of Respiratory And Critical Care Medicine]

    Abstract

    RUNX1 Targeting AKT3 Promotes Alveolar Hypercoagulation and Fibrinolytic Inhibition in LPS Induced ARDS

    Genes associated with RUNX1 were screened by CHIP-seq, among which the target gene was verified by Dual Luciferase experiment. Then the efficacy of the target gene on alveolar hypercoagulation and fibrinolytic inhibition in LPS-induced acute respiratory distress syndrome (ARDS) was explored.
    [Respiratory Research]

    Full Article

    Tobacco-Derived and Tobacco-Free Nicotine Cause Differential Inflammatory Cell Influx and MMP-9 in Mouse Lung

    Lung inflammatory cell counts, cytokine/chemokine levels, and matrix metalloproteinase (MMP) protein abundance and activity levels were determined by flow cytometry, ELISA, immunoblotting, and gel zymography, respectively.
    [Respiratory Research]

    Full Article

    Inhibition of Mucus Secretion by Niclosamide and Benzbromarone in Airways and Intestine

    Researchers investigated the effects of the two anoctamin 1-inhibitors niclosamide and benzbromarone in vitro and in vivo in mouse models for cystic fibrosis and asthma.
    [Scientific Reports]

    Full Article

    Serum Protein Fishing for Machine Learning-Boosted Diagnostic Classification of Small Nodules of Lung

    Scientists developed a serum protein fishing-based spectral library for data independent acquisition analysis and a machine learning-boosted protein panel for diagnosis of early NSCLC and classification of benign and malignant small nodules.
    [ACS Nano]

    AbstractGraphical Abstract

    Circulating Tumor Cells Reveal Early Predictors of Disease Progression in Patients with Stage III NSCLC Undergoing Chemoradiation and Immunotherapy

    Using an ultrasensitive graphene oxide microfluidic chip nanotechnology built with graphene oxide sheets, researchers were able to demonstrate that circulating tumor cells could be specifically isolated and molecularly characterized to predict future progression in patients with stage III NSCLC.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Hedgehog Signaling Is Involved in Acquired Resistance to KRASG12C Inhibitors in Lung Cancer Cells

    KRASG12C inhibitors induced the formation of primary cilia and activated the Hedgehog-GLI-1 pathway.
    [Cell Death & Disease]

    Full Article

    Transbronchial Cryoablation in Peripheral Lung Parenchyma with a Novel Thin Cryoprobe and Initial Clinical Testing

    Nine patients with stage IA peripheral lung cancer or metastases underwent transbronchial cryoablation with this cryoprobe under the guidance of navigation bronchoscopy and cone-beam CT.
    [Thorax]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    REVIEWS

    The Evolution of In Vitro Models of Lung Fibrosis: Promising Prospects for Drug Discovery

    The authors review new model systems have been developed to enhance the translatability of preclinical drug testing and bridge the gap to human clinical trials.
    [European Respiratory Review]

    Full Article

    Pyroptosis: A Double-Edged Sword in Lung Cancer and Other Respiratory Diseases

    Emerging evidences have shown that pyroptosis contributes to many pulmonary diseases, especially lung cancer, and pneumonia. Scientists review the multifaceted roles of pyroptosis in respiratory diseases.
    [Cell Communication And Signaling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Canadian Cancer Society Awards Two UM Emerging Scholars

    Dr. Tara Horrill and Dr. Joel Pearson at the Rady Faculty of Health Sciences were among the winners of the Canadian Cancer Society’s 2023 Emerging Scholar Research Grants competition.
    [University of Manitoba]

    Press Release

    EPA Scraps Plan to End Mammal Testing by 2035

    The US Environmental Protection Agency (EPA) has abandoned a controversial plan to phase out all use of mammals to test the safety of chemicals by 2035. The hard deadline—imposed in 2019 to accelerate a move toward nonanimal models such as computer programs and “organs on a chip”—made EPA unique among US federal agencies.
    [Science Insider]

    News Article
    FEATURED EVENT

    2024 Biology of Acute Respiratory Infection Seminar GRC

    February 24 – 25, 2024
    Galveston, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Host-Pathogen Metabolic Interactions

    Rutgers Health – Newark, New Jersey, United States

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

    Postdoctoral Research Associate – Morphogenesis of the Lung and Mammary Gland

    Princeton University – Princeton, New Jersey, United States

    Research Assistant – Lung Stem Cells and Disease

    University of Cambridge – Cambridge, England, United Kingdom

    Research Fellow – Breast and Lung Cancer Diagnosis

    University of Melbourne – Melbourne, Australia

    > See All Jobs

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