Pulmonary Cell News Volume 13.04 | Feb 1 2024

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    Laurisa Dohm
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    2024-02-01 | PULCN 13.04


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.04 – 1 February, 2024
    TOP STORY

    Tumor- and Circulating-Free DNA Methylation Identifies Clinically Relevant Small Cell Lung Cancer Subtypes

    Using genomic-wide reduced-representation bisulfite sequencing in two cohorts totaling 179 SCLC patients and using machine learning approaches, the authors reported a highly accurate DNA methylation-based classifier that could distinguish SCLC subtypes.
    [Cancer Cell]

    Full ArticleGraphical Abstract
    Learn how the SARS-CoV-2 genotype impacts viral load, transmission, and spread with Dr. Judd F. Hultquist.
    PUBLICATIONSRanked by the impact factor of the journal

    Airway Epithelial-Targeted Nanoparticle Reverses Asthma in Inhalation Therapy

    After loading dexamethasone, neonatal-Fc-receptor-targeted peptide (FcBP)-functionalization could effectively help nanoparticles cross the airway epithelial layer and be endocytosed by inflammatory cells, resulting in a marked decrease in inflammatory cytokines.
    [Journal Of Controlled Release]

    AbstractGraphical Abstract

    COPD Basal Cells Are Primed towards Secretory to Multiciliated Cell Imbalance Driving Increased Resilience to Environmental Stressors

    Investigators delineated the impact of prevalent pollutants such as carbon and zinc oxide nanoparticles, on cellular function and progeny in primary human bronchial epithelial cells from end-stage COPD, early disease,and pulmonary healthy individuals.
    [Thorax]

    Full Article

    Culture and Expansion of Murine Proximal Airway Basal Stem Cells

    Researchers used ROCK inhibitor Y-27632-containing 3T3-CM, MEF-CM, and RbEF-CM to determine the proper feeder-free culture system that could maintain in vitro stem cell morphology of mouse airway basal stem cells.
    [Stem Cell Research & Therapy]

    Full Article

    Drebrin Is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development

    Using mice bearing a transgelin-Cre targeted deletion of drebrin in pulmonary fibroblasts and pericytes, scientists examined alterations in alveolar septal outgrowth, lung fibroblasts spreading and migration, and actomyosin function.
    [American Journal Of Respiratory Cell And Molecular Biology]

    Abstract

    FTO Deficiency Alleviate LPS-induced ALI by TXNIP/NLPR3-Mediated Alveolar Epithelial Cell Pyroptosis

    Lung epithelial fat mass and obesity-associated (FTO) knockout mice and FTO protein knockdown/overexpression A549 cell lines were constructed to evaluate the effects of FTO on acute lung injury.
    [American Journal Of Respiratory Cell And Molecular Biology]

    Abstract

    Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Non-Small Cell Lung Cancer Patients

    The germline mutation USP36 rs3744797 was found to facilitate proliferation, migration, and resistance to EGFR-TKIs via upregulating MLLT3 expression in vitro and in vivo.
    [Clinical Cancer Research]

    Abstract

    Targeting Focal Adhesion Kinase Boosts Immune Response in KRAS/LKB1 Co-Mutated Lung Adenocarcinoma via Remodeling the Tumor Microenvironment

    Scientists explored the specific characteristics of tumor microenvironment in KRASG12DLKB1−/− (KL) tumors using syngeneic KL and KRASG12DTP53−/− lung cancer mouse models.
    [Experimental Hematology & Oncology]

    Full Article

    LUBAC Promotes Angiogenesis and Lung Tumorigenesis by Ubiquitinating and Antagonizing Autophagic Degradation of HIF1α

    Investigators showed that LUBAC increased dypoxia-inducible factor 1 (HIF1) α protein expression in cultured cells and tissues of human lung cancer and enhanced HIF1α DNA-binding and transcriptional activities, which were dependent upon LUBAC enzymatic activity.
    [Oncogenesis]

    Full Article
    Request a free wallchart for a quick reference on growing organoids from stem cells.
    REVIEWS

    Idiopathic Pulmonary Fibrosis: From Common Microscopy to Single-Cell Biology and Precision Medicine

    The authors approach the fascinating historical evolution of knowledge about idiopathic pulmonary fibrosis from the past century, until the current century, when the explosive progress in molecular genetics, epigenetics resulted in a huge advance in unveiling the pathogenic mechanisms of the disease.
    [American Journal Of Respiratory And Critical Care Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Open-Access Papers Draw More Citations from a Broader Readership

    Researchers report that open-access papers have a greater reach than paywalled ones in two key ways: They attract more total citations, and those citations come from scholars in a wider range of locations, institutions, and fields of research.
    [ScienceInsider]

    Editorial
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    JOB OPPORTUNITIES

    Research Assistant – Cancer Biology

    University of Texas MD Anderson Cancer Center – Houston, Texas, United States

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    University of Texas at Tyler – Tyler, Alabama, United States

    Postdoctoral Researcher – Host-Pathogen Metabolic Interactions

    Rutgers Health – Newark, New Jersey, United States

    Postdoctoral Research Associate – Morphogenesis of the Lung and Mammary Gland

    Princeton University – Princeton, New Jersey, United States

    Research Assistant – Lung Stem Cells and Disease

    University of Cambridge – Cambridge, England, United Kingdom

    > See All Jobs

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