Pulmonary Cell News Volume 13.05 | Feb 8 2024

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    2024-02-08 | PULCN 13.05


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.05 – 8 February, 2024
    TOP STORY

    Boron Nitride Nanosheets Induce Lipid Accumulation and Autophagy in Human Alveolar Lung Epithelial Cells Cultivated at Air-Liquid Interface

    Cellular interaction and effects of hexagonal boron nitride nanosheets was investigated in alveolar epithelial cells cultured on porous inserts and exposed under air−liquid interface conditions for 24 hours.
    [Small]

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    PUBLICATIONSRanked by the impact factor of the journal

    GLUT1 Mediates the Release of HMGB1 from Airway Epithelial Cells in Mixed Granulocytic Asthma

    BALB/c mice, the airway epithelial cell line BEAS-2B, or primary human bronchial epithelial cells were immunized with allergens.
    [Biochimica Et Biophysica Acta-Molecular Basis Of Disease]

    AbstractGraphical Abstract

    GTS-21 Attenuates ACE/ACE2 Ratio and Glycocalyx Shedding in Lipopolysaccharide-Induced Acute Lung Injury by Targeting Macrophage Polarization Derived ADAM-17

    Researchers developed mouse models of acute lung injury and alveolar epithelial type II cells injury following treatment with lipopolysaccharides and different polarized macrophage supernatants, respectively.
    [International Immunopharmacology]

    Full Article

    LL-37 Improves Sepsis-Induced Acute Lung Injury by Suppressing Pyroptosis in Alveolar Epithelial Cells

    Scientists utilized both in vivo and in vitro sepsis-associated acute lung injury models to understand the underlying molecular pathways.
    [International Immunopharmacology]

    Full ArticleGraphical Abstract

    Nicotinamide Phosphoribose Transferase Facilitates Macrophage-Mediated Pulmonary Fibrosis through the Sirt1-Smad7 Pathway in Mice

    A conditional knockout of nicotinamide phosphoribose transferase in lung macrophages curtailed the bleomycin-induced inflammatory responses and significantly mitigated pulmonary fibrosis.
    [European Journal Of Pharmacology]

    Abstract

    Mesenchymal Stem Cells Inhibit Ferroptosis by Activating the Nrf2 Antioxidation Pathway in Severe Acute Pancreatitis-Associated Acute Lung Injury

    Scientists investigated the protective effects of MSCs against severe acute pancreatitis-associated acute lung injury and its underlying mechanisms. Their results suggest that MSCs mitigate pathological injury, hemorrhage, edema, inflammatory response in lung tissue, and lipopolysaccharide-induced cell damage in RLE-6TN cells.
    [European Journal Of Pharmacology]

    Full Article

    Combining Genomic Biomarkers to Guide Immunotherapy in Non-Small Cell Lung Cancer

    To develop a combinatorial biomarker strategy with increased specificity for immune checkpoint blockade unresponsiveness in NSCLC, researchers performed a comprehensive analysis of 254 NSCLC patients treated with PD-(L)1 blockade monotherapy.
    [Clinical Cancer Research]

    Abstract

    Re-Expression of Epigenetically Silenced PTPRR by Histone Acetylation Sensitizes RAS-Mutant Lung Adenocarcinoma to SHP2 Inhibition

    Exogenous expression of silenced protein tyrosine phosphatase receptor type R (PTPRR) suppressed the proliferation and migration of lung cancer cells.
    [Cellular And Molecular Life Sciences]

    Abstract
    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    Inhibitor of PD-1/PD-L1: A New Approach May Be Beneficial for the Treatment of Idiopathic Pulmonary Fibrosis

    The authors discuss the application of PD-1/PD-L1 checkpoint in idiopathic pulmonary fibrosis, with the aim of finding a new direction for idiopathic pulmonary fibrosis treatment.
    [Journal Of Translational Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Future of Cancer Research in Yorkshire Receives £8.9 Million Funding Boost

    The University of Sheffield and Yorkshire Cancer Research have announced seven world-leading research studies that will aim to help more people survive cancer by exploring new solutions in cancer prevention, diagnosis and treatment.
    [University of Sheffield]

    Press Release
    FEATURED EVENT

    3D Cell Culture & Organ Modelling 2024

    March 18 – 19, 2024
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    JOB OPPORTUNITIES

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    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Research Associate – Cardiovascular, Lung, and Metabolic Diseases

    University of Texas at Tyler – Tyler, Alabama, United States

    Postdoctoral Researcher – Host-Pathogen Metabolic Interactions

    Rutgers Health – Newark, New Jersey, United States

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