Pulmonary Cell News Volume 13.07 | Feb 22 2024

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    2024-02-22 | PULCN 13.07


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.07 – 22 February, 2024
    TOP STORY

    Human NTHL1 Expression and Subcellular Distribution Determines Cisplatin Sensitivity in Human Lung Epithelial and Non-Small Cell Lung Cancer Cells

    Researchers investigated how NTHL1 expression levels impacted cellular sensitivity to cisplatin in non-tumorigenic immortalized cells and five NSCLC cell lines.
    [Nar Cancer]

    Full Article
    Graphical Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    Proteomic and Metabolomic Proof of Concept for Unified Airways in Chronic Rhinosinusitis and Asthma

    Scientists analyzed the expression of proteins and metabolites in nasal lavage fluid cells and induced sputum cells. Differentially expressed proteins and their function-related metabolites in the upper and lower airways of chronic rhinosinusitis with nasal polyps patients with or without asthma were identified.
    [Annals Of Allergy Asthma & Immunology]

    Abstract

    miR-34c-5p Inhibited Fibroblast Proliferation, Differentiation and Epithelial-Mesenchymal Transition in Benign Airway Stenosis via MDMX/p53 Pathway

    Investigators explored the role and mechanism of miR-34c-5p in benign airway stenosis (BAS). The expression of miR-34c-5p in BAS granulation tissues showed a significant down-regulation compared with the normal control group.
    [Functional & Integrative Genomics]

    Full Article

    Alleviation of Pulmonary Fibrosis by the Dual PPAR Agonist Saroglitazar and Breast Milk Mesenchymal Stem Cells via Modulating TGFß/SMAD Pathway

    Researchers investigated the potential roles of saroglitazar and/or breast milk mesenchymal stem cells in pumonary fibrosis and to spot their underlying protective mechanisms.
    [Naunyn-Schmiedebergs Archives Of Pharmacology]

    Full Article

    TRAIL Predisposes Non-Small Cell Lung Cancer to Ferroptosis by Regulating ASK-1/JNK1 Pathway

    Researchers assessed the relationship between TNF-related apoptosis-inducing ligand (TRAIL) and ferroptosis in NSCLC development.
    [Discover Oncology]

    Full Article

    Immunophenotyping of Peripheral Blood in NSCLC Patients Discriminates Responders to Immune Checkpoint Inhibitors

    Scientists assessed the relationship between TNF-related apoptosis-inducing ligand (TRAIL) and ferroptosis in NSCLC development.
    [Discover Oncology]

    Full Article

    18β-Glycyrrhetinic Acid Suppresses Lewis Lung Cancer Growth through Protecting Immune Cells from Ferroptosis

    Investigators studied whether the enhanced immune response via inhibiting immune cell ferroptosis contributed to the anticancer effect of 18β-glycyrrhetinic acid. Lewis Lung carcinoma mouse model and Murine CD8+ T cell culture model were used to examine the changes of immune response.
    [Cancer Chemotherapy And Pharmacology]

    Abstract

    NFATc2 Promotes Lactate and M2 Macrophage Polarization through USP17 in Lung Adenocarcinoma

    Scientists studied how NFATc2 regulated macrophage properties in lung adenocarcinoma. Higher expression of NFATc2 was observed in the lung adenocarcinoma tissues than in the normal lung tissues.
    [Anti-Cancer Drugs]

    Abstract
    View tips on how to organize your lab notebooks, references and protocols.
    REVIEWS

    Calcium Signaling in Airway Epithelial Cells: Current Understanding and Implications for Inflammatory Airway Disease

    The authors discuss the role of major Ca2+ signaling pathways found in airway epithelial cells and their roles in mediating airway inflammation, mucociliary clearance, and surfactant production.
    [Arteriosclerosis Thrombosis And Vascular Biology]

    Abstract
    INDUSTRY AND POLICY NEWS

    More People Die after Smoking Drugs than Injecting Them, Study Finds

    Smoking has surpassed injecting as the most common way of taking drugs in US overdose deaths, a new government study suggests. The Centers for Disease Control and Prevention called its study the largest to look at how Americans took the drugs that killed them.
    [Stat]

    Press Release
    FEATURED EVENT

    2024 Fibroblast Growth Factors in Development and Disease Conference GRC

    March 24 – 29, 2024
    Galveston, Texas, United States

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    JOB OPPORTUNITIES

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    University of Vermont – Burlington, Vermont, United States

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    Queen’s University Belfast – Belfast, Ireland, United Kingdom

    Fellowship – Interventional Pulmonary

    University of Kentucky – Lexington, Kentucky, United States

    Department Chair – Cell Biology and Human Anatomy

    UC Davis – Davis, California, United States

    Research Fellow – Experimental Medicine

    Queens University Belfast – Belfast, Ireland, United Kingdom

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