 | | Vol. 13.08 – 29 February, 2024 |
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| Researchers studied 246,102 single epithelial cells from 16 early-stage lung adenocarcinomas (LUADs) and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers determined whether ezetimibe has therapeutic potential against idiopathic pulmonary fibrosis. Primary lung fibroblasts isolated from both humans and mice were employed for mechanistic in vitro experiments.
[European Respiratory Journal] |
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| Scientists investigated the effects of passive sensitization on IL-5, NF-κB, HDAC-2, ACh, and ChAT in human bronchial epithelial cells and the effects of fluticasone furoate and umeclidinium alone and in combination on these responses.
[Respiratory Research] |
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| Investigators identified ferroptosis of type II alveolar epithelial cells in mice with Bet v 1-induced asthma. Further analysis revealed that treatment with ferrostatin-1 reduced TH2/TH17-related inflammation and alleviated epithelial damage in mice with Bet v 1-induced asthma.
[Cell Death Discovery] |
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| Scientists investigated the effects of cigarette smoke and e-cigarette smoke of different flavors on human lung bronchial epithelial cells. Real-time smoke exposure was carried out using an air–liquid interface system, and cell viability was assessed.
[Scientific Reports] |
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| Investigators explored the roles of B cell lymphoma 6 (BCL6) in the progression of bronchopulmonary dysplasia and its downstream mechanisms.
[Experimental Lung Research] |
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| Scientists identified an intermediate high-plastic cell state marked by the expression of an AST plasticity signature and Krt6a. Notably, expression of the AST plasticity signature and KRT6A at baseline correlated with poor adagrasib responses.
[Cancer Cell] |
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| In order to verify the anticancer and antimetastatic effect of vitamin C, researchers set up H22 pulmonary metastasis mouse model.
[Molecular Nutrition & Food Research] |
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| NSCLC cell clusters were extracted from single cell-sequencing dataset GSE131907, which were combined with hypoxia-related genes to group clusters. qRT-PCR and western blot were used to validate the expression of target gene.
[Aging] |
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| Scientists introduce recent progress in the production methods of lung organoids, strategies for improving maturity, functionality, and complexity of organoids, and their application in disease modeling, including respiratory infection and pulmonary fibrosis.
[Journal of Tissue Engineering] |
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| Nano-X Imaging, Ltd. will conduct a clinical study evaluating the Nanox.ARC 3D imaging system in a clinical outpatient setting at Beilinson Hospital. The study will specifically assess diagnostic capabilities compared with conventional two-dimensional radiography for the detection of lung and chest disease in adults.
[Nano-X Imaging, Ltd. (Globe Newswire)] |
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| March 21 – 23, 2024
Tokyo, Japan |
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| | University of Wisconsin – Madison, Wisconsin, United States |
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| | Augusta University – Augusta, Georgia, United States |
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| | University of Vermont – Burlington, Vermont, United States |
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| | Queen’s University Belfast – Belfast, Ireland, United Kingdom |
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| | University of Kentucky – Lexington, Kentucky, United States |
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Cancer Stem Cell News
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