Pulmonary Cell News Volume 13.09 | Mar 07 2024

    0
    5







    2024-03-07 | PULCN 13.09


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.09 – 7 March, 2024
    TOP STORY

    KEAP1 Promotes Anti-Tumor Immunity by Inhibiting PD-L1 Expression in NSCLC

    Scientists discovered that KEAP1 serves as an E3 ligase to promote PD-L1 ubiquitination and degradation. They found that overexpression of KEAP1 suppressed tumor growth and promoted cytotoxic T cell activation in vivo.
    [Cell Death & Disease]

    Full Article
    Grow Functional Airway Organoids with PneumaCultâ„¢
    PUBLICATIONSRanked by the impact factor of the journal

    P. aeruginosa tRNA-fMet Halves Secreted in Outer Membrane Vesicles Suppress Lung Inflammation in Cystic Fibrosis

    Investigators demonstrated that tobramycin increases 5′ tRNA-fMet halves in outer membrane vesicles secreted by laboratory and cystic fibrosis clinical isolates of P. aeruginosa.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Circulating miR-let7a Levels Predict Future Diagnosis of Chronic Thromboembolic Pulmonary Hypertension

    Researchers investigated dysregulated miRNA signatures during the acute phase of pulmonary embolism and test their diagnostic and predictive value for future diagnosis of chronic thromboembolic pulmonary hypertension.
    [Scientific Reports]

    Full Article

    Contribution of Small Airway Inflammation to the Development of COPD

    Investigators explored whether small airway inflammation was the risk for the development of COPD.
    [BMC Pulmonary Medicine]

    Full Article

    YES1 as a Potential Target to Overcome Drug Resistance in EGFR-Deregulated Non-Small Cell Lung Cancer

    The authors investigated the expression and functional role of YES1, one of the Src-family kinases, in epidermal growth factor receptor (EGFR)-TKI-resistant NSCLC. YES1 expression was elevated in gefitinib-resistant HCC827 cells, harboring EGFR mutations.
    [Archives Of Toxicology]

    Abstract

    The SOX2/PDIA6 Axis Mediates Aerobic Glycolysis to Promote Stemness in Non-Small Cell Lung Cancer Cells

    Researchers investigated the biological function of PDIA6 in NSCLC. SOX2 and PDIA6 expression in NSCLC tissues and the regulatory relationship between them were analyzed using bioinformatics.
    [Journal Of Bioenergetics And Biomembranes]

    Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    RNA m6A Methylation and Regulatory Proteins in Pulmonary Arterial Hypertension

    Scientists explore the mechanism and function of m6A in the pathogenesis of pulmonary arterial hypertension (PAH) and discuss the potential targeting of RNA m6A methylation modification as a treatment for PAH.
    [Hypertension Research]

    AbstractPress Release
    INDUSTRY AND POLICY NEWS

    Viltolarsen Linked to Increased Pulmonary Function in Duchenne Muscular Dystrophy

    Treatment with viltolarsen at 48 weeks improved pulmonary function in a cohort of pediatric patients with Duchenne muscular dystrophy amenable to exon 53 skipping compared with those receiving standard care.
    [Healio]

    Press Release
    FEATURED EVENT

    2024 Cincinnati International Symposium

    April 4 – 5, 2024
    Cincinnati, Ohio, United States

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Pulmonary Medicine

    University of Texas Health Science Center – Houston, Texas, United States

    Research Specialist – Lung Disease Research

    University of Wisconsin – Madison, Wisconsin, United States

    Postdoctoral Fellow – Biochemistry and Molecular Biology

    Augusta University – Augusta, Georgia, United States

    Associate/Full Professor – Pulmonary

    University of Vermont – Burlington, Vermont, United States

    Fellowship – Interventional Pulmonary

    University of Kentucky – Lexington, Kentucky, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2