Pulmonary Cell News Volume 13.10 | Mar 13 2024

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    Noshin Noorjahan
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    2024-03-14 | PULCN 13.10


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.10 – 14 March, 2024
    TOP STORY

    IL-13 Facilitates Ferroptotic Death in Asthmatic Epithelial Cells via SOCS1-Mediated Ubiquitinated Degradation of SLC7A11

    Investigators demonstrated that the serum level of malondialdehyde, an index of lipid peroxidation, positively correlated with IL-13 level and negatively correlated with the predicted forced expiratory volume in one second in asthmatics.
    [Redox Biology]

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    Endoplasmic Reticulum Stress Enhances the Expression of TLR3-Induced TSLP by Airway Epithelium

    Researchers determined if endoplasmic reticulum stress and the unfolded protein response signaling were involved in thymic stromal lymphopoietin induction in the airway epithelium.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Functional Roles of CD26/DPP4 in Lipopolysaccharide-Induced Lung Injury

    Investigators characterized the functional role of CD26/Dipeptidyl peptidase-4 (DPP4) expression in lipopolysaccharide-induced lung injury in mice, isolated alveolar macrophages, and cultured lung endothelial cells.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract

    Tempol Alleviates Acute Lung Injury by Affecting Glutathione Synthesis through Nrf2 and Inhibiting Ferroptosis in Lung Epithelial Cells

    Scientists investigated the regulatory mechanism of Tempol in the treatment of acute lung injury (ALI). A mouse model of ALI was established, and HE staining was used to examine histomorphology.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Phosphorylated SHMT2 Regulates Oncogenesis through m6A Modification in Lung Adenocarcinoma

    The authors clarified that mitogen-activated protein kinase 1-mediated phosphorylation at Ser90 was the key mechanism underlying serine hydroxymethyltransferase 2 (SHMT2) upregulation in lung adenocarcinoma.
    [Advanced Biology]

    Full Article

    METTL3-Mediated the m6A Modification of SF3B4 Facilitates the Development of Non-Small Cell Lung Cancer by Enhancing LSM4 Expression

    Quantitative real-time PCR and western blot were employed to detect the mRNA and protein levels of SF3B4, Sm-like protein 4 (LSM4), and methyltransferase-like 3 (METTL3).
    [Thoracic Cancer]

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    REVIEWS

    The Emerging Role of Extracellular Vesicles in Bronchopulmonary Dysplasia

    The authors explore some of the recent advances in this field and the evolving knowledge of the role of extracellular vesicles in bronchopulmonary dysplasia.
    [American Journal Of Physiology-Lung Cellular And Molecular Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    LCRF Announces Grant Awards for ADC Research

    The Lung Cancer Research Foundation (LCRF) announced three research grant awards focused on further understanding of the mechanism of action of antibody drug conjugates (ADCs) and exploring the use of ADCs in lung cancer types beyond NSCLC.
    [Lung Cancer Research Foundation]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Liposarcoma, Breast Cancer, and NSCLC

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Immunology of Airway Allergy and Asthma

    University of Denmark – Lyngby, Denmark

    Assistant Professor – Pulmonary Medicine

    University of Texas Health Science Center – Houston, Texas, United States

    Research Specialist – Lung Disease Research

    University of Wisconsin – Madison, Wisconsin, United States

    Postdoctoral Fellow – Biochemistry and Molecular Biology

    Augusta University – Augusta, Georgia, United States

    > See All Jobs

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