Pulmonary Cell News Volume 13.11 | Mar 28 2024

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    Noshin Noorjahan
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    2024-03-28 | PULCN 13.11


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.11 – 28 March, 2024
    TOP STORY

    Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection

    Investigators compared exopolysaccharide-producers versus non-producers and a virulent Escherichia coli lung infection model in male and female mice.
    [Cell]

    AbstractPress ReleaseGraphical Abstract
    STEMCELL has implemented an Environmental Management System that is now ISO 14001-certified.
    PUBLICATIONSRanked by the impact factor of the journal

    MSCs Alleviate LPS-Induced Acute Lung Injury by Inhibiting the Proinflammatory Function of Macrophages in Mouse Lung Organoid-Macrophage Model

    Lung tissues were collected from mice for mouse lung organoid construction. Alveolar macrophages derived from bronchoalveolar lavage and interstitial macrophages (IMs) derived from lung tissue were co-cultured, with novel matrigel-spreading lung organoids to construct an in vitro model of lung organoids–immune cells.
    [Cellular and Molecular Life Sciences]

    Full Article

    Bile Acid Metabolites Enhance Expression of Cathelicidin Antimicrobial Peptide in Airway Epithelium through Activation of the TGR5-ERK1/2 Pathway

    Researchers investigated the effects of bile acid metabolites produced from lithocholic acid by microbiota, on the regulation of innate immune responses connected to the expression of host defense peptide cathelicidin in lung epithelial cells.
    [Scientific Reports]

    Full Article

    Stimulatory Effect of Methylglyoxal on Capsaicin-Sensitive Lung Vagal Afferents in Rats: Role of TRPA1

    Scientists showed that intravenous injection of methylglyoxal in anesthetized, spontaneously breathing rats elicited pulmonary chemoreflexes characterized by apnea, bradycardia, and hypotension.
    [American Journal Of Physiology-Regulatory Integrative And Comparative Physiology]

    Abstract

    KN046, a Bispecific Antibody against PD-L1 and CTLA-4, Plus Chemotherapy as First-Line Treatment for Metastatic NSCLC: A Multicenter Phase II Trial

    In this multicenter phase II trial, patients with nonsquamous (non-sq) NSCLC received pemetrexed, whereas those with sq-NSCLC received paclitaxel, plus KN046 and carboplatin. Following four cycles, maintenance therapy included KN046 with pemetrexed for non-sq-NSCLC and KN046 for sq-NSCLC.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Activation of Polyamine Catabolism Promotes Glutamine Metabolism and Creates a Targetable Vulnerability in Lung Cancer

    Scientists reported that activation of polyamine catabolism promoted glutamine metabolism, leading to a targetable vulnerability in lung cancer.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract
    Free Wallchart: Dynamic Modeling in Organoids
    REVIEWS

    Enigmatic Exosomal Connection in Lung Cancer Drug Resistance

    Investigators summarize the current knowledge on conventional and emerging drug resistance mechanisms and the involvement of exosomes as well as exosome-mediated factors mediating drug resistance in lung cancer.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Abnormal Expression of Krüppel-Like Transcription Factors and Their Potential Values in Lung Cancer

    The authors review the recent some progresses of the oncogenic Krüppel-like factors with their potential values for diagnosis, prognosis, and molecular target in lung cancer.
    [Heliyon]

    Full Article
    INDUSTRY AND POLICY NEWS

    £1.7 Million for the World’s First Vaccine to Prevent Lung Cancer

    Researchers at the University of Oxford, the Francis Crick Institute, and University College London have been granted £1.7 million of funding from Cancer Research UK and the CRIS Cancer Foundation to develop a lung cancer vaccine.
    [Cancer Research UK]

    Press Release
    FEATURED EVENT

    5th International Conference on Cell and Experimental Biology

    April 22 – 25, 2024
    Baltimore, Maryland, United States

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    JOB OPPORTUNITIES

    Posdoctoral Fellow Positions – Epidemiology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Position – Organoid-Based Systems for Anti-Infective Drug Discovery

    EPFL – Lausanne, Switzerland

    Postdoctoral Research Fellow – Liposarcoma, Breast Cancer, and NSCLC

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Immunology of Airway Allergy and Asthma

    University of Denmark – Lyngby, Denmark

    Assistant Professor – Pulmonary Medicine

    University of Texas Health Science Center – Houston, Texas, United States

    > See All Jobs

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