 | | Vol. 12.47 – 30 November, 2023 |
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| The Phase II nonrandomized clinical trial enrolled 42 patients with uncommon EGFR mutations, of whom 40 were eligible.
[Jama Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators observed that bleomycin induced enhanced mitophagy accompanied by increased mitochondrial ROS content in the murine alveolar epithelial cell line MLE12.
[Biomedicine & Pharmacotherapy] |
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| Both lipopolysaccharides-induced mouse and alveolar organoid acute lung injury models were established to confirm the potential therapeutic effect of mesenchymal stem cells secreted keratinocyte growth factor (KGF).
[Biomedicine & Pharmacotherapy] |
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| Researchers showed that pretreatment of human bronchial epithelial cells with interferon-γ markedly increased IL-6 production induced by the toll-like receptor 3 agonist poly(I:C) from 0.4 ± 0.1 to 4.1 ± 0.4 ng/mL.
[Scientific Reports] |
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| | Scientists confirmed that WDR63 was an important player in recombinant adeno-associated virus (AAV) 2.5T transduction of human airway epithelium, while not being involved in vector internalization and nuclear entry.
[Journal Of Virology] |
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| Forced expression of TRIM3 promoted cell death by enhancing the cellular level of ROS and lipid peroxidation. An in vivo study determined that TRIM3 overexpression diminished the tumorigenicity of NSCLC cells, indicating that TRIM3 functioned as a tumor suppressor in NSCLC.
[Cell Death & Differentiation] |
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| Researchers examined oncogenic transformation in mouse Gram-domain containing 2+ alveolar epithelial type I cells via oncogenic KRASG12D.
[Cell Reports] |
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| A novel hybrid murine model of lung cancer with interstitial pneumonia was established via bleomycin-induced pulmonary fibrosis followed by orthotopic lung cancer cell transplantation into the lungs.
[Journal Of Translational Medicine] |
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| Investigators demonstrated that the pro-metastatic activity of ROLLCSC was achieved through its function as a competing endogenous RNA of miR-5623-3p and miR-217-5p to stimulate lipid metabolism.
[International Journal Of Biological Macromolecules] |
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| The authors look at the current evidence behind molecular monitoring in lung transplantation and ask if it is ready for routine clinical use.
[European Respiratory Review] |
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| Sanofi plans to seek US approval for its best-selling anti-inflammatory drug Dupixent to be used in the treatment of “smoker’s lung”, also known as COPD, after a second large trial showed significant benefits.
[Reuters] |
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| January 17 – 19, 2024
Chiba, Japan |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | Indiana University – Indiana, Pennsylvania, United States |
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| | Rutgers Health – Newark, New Jersey, United States |
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| | Royal College of Surgeons in Ireland – Dulin, Ireland |
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| | Cedars-Sinai – Los Angeles, California, United States |
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