Pulmonary Cell News Volume 12.49 | Dec 14 2023

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    Laurisa Dohm
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    2023-12-14 | PULCN 12.49


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 12.49 – 14 December, 2023
    TOP STORY

    CellCharter Reveals Spatial Cell Niches Associated with Tissue Remodeling and Cell Plasticity

    The authors presented CellCharter, an algorithmic framework to identify, characterize, and compare cellular niches in spatially resolved datasets.
    [Nature Genetics]

    Abstract
    See how small molecules affect key signaling pathways in cancer research. Download your free wallchart now.
    PUBLICATIONSRanked by the impact factor of the journal

    17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma

    Researchers revealed that the 17q21 risk allele induced a genotype- and asthma/wheeze phenotype-dependent enhancement of mucosal GSDMB expression as the only relevant 17q21-encoded gene in children with preschool wheeze.
    [American Journal Of Respiratory And Critical Care Medicine]

    Abstract

    Airway Environment Drives the Selection of Quorum Sensing Mutants and Promote Staphylococcus aureus Chronic Lifestyle

    Using S. aureus USA300 as well as clinical isolates, scientists demonstrated that quorum-sensing dysfunction, a hallmark of S. aureus adaptation, correlated with a greater ability to consume free sialic acid, providing a growth advantage in an air-liquid interface model and in vivo.
    [Nature Communications]

    Full Article

    Endothelium-Derived Engineered Extracellular Vesicles Protect the Pulmonary Endothelial Barrier in Acute Lung Injury

    Engineered extracellular vesicles that were modified with lung microvascular endothelial cell-targeting peptides exhibited a prolonged retention time in lung tissues and targeted lung microvascular endothelial cells in vivo and in vitro.
    [Advanced Science]

    Full Article

    In Vivo Protein Turnover Rates in Varying Oxygen Tensions Nominate MYBBP1A as a Mediator of the Hyperoxia Response

    The authors systematically investigated protein turnover rates in mouse heart, lung, and brain under different inhaled oxygen tensions, and found that the lung proteome was the most responsive to varying oxygen tensions.
    [Science Advances]

    Full Article

    The Interplay between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy

    The negative feedback regulation between EZH2 and HIF-1α was confirmed in lung cancer patient tissues and a database of cell lines.
    [Advanced Science]

    Full Article

    MiR-204 Suppresses Cancer Stemness and Enhances Osimertinib Sensitivity in Non-Small Cell Lung Cancer by Targeting CD44

    Scientists explored novel miRNA–mRNA regulatory mechanisms that contribute to osimertinib resistance in lung cancer. They found that miR-204 expression in osimertinib-resistant lung cancer cells was markedly reduced compared to that in osimertinib-sensitive parental cells.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    HOMER3 Promotes Non-Small Cell Lung Cancer Growth and Metastasis Primarily through GABPB1-Mediated Mitochondrial Metabolism

    Lung cancer cells with low levels of HOMER3 were found to show significant mitochondrial dysfunction, thereby suppressing their proliferation and metastasis in vivo and in vitro.
    [Cell Death & Disease]

    Full Article

    SOS2 Modulates the Threshold of EGFR Signaling to Regulate Osimertinib Efficacy and Resistance in Lung Adenocarcinoma

    Using a long-term in situ resistance assay, most osimertinib-resistant cultures exhibited a hybrid epithelial/mesenchymal phenotype associated with reactivated RTK/AKT signaling.
    [Molecular Oncology]

    Abstract
    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    REVIEWS

    Emerging Delivery Approaches for Targeted Pulmonary Fibrosis Treatment

    The authors review recent advances on pulmonary fibrosis pathology, mechanism and targets related to pulmonary fibrosis, development of various drug delivery systems based on small molecules, RNAs, oligonucleotides, peptides, antibodies, exosomes, and stem cells for the treatment of pulmonary fibrosis.
    [Advanced Drug Delivery Reviews]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    More Than 10,000 Research Papers Were Retracted in 2023 — A New Record

    The number of retractions issued for research articles in 2023 has passed 10,000 — smashing annual records — as publishers struggle to clean up a slew of sham papers and peer-review fraud.
    [Nature News]

    Editorial
    FEATURED EVENT

    6th DNA Repair/Replication Structures and Cancer Conference

    February 14 – 18, 2024
    Cancun, Mexico

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    JOB OPPORTUNITIES

    Research Fellow – Breast and Lung Cancer Diagnosis

    University of Melbourne – Melbourne, Australia

    Research Associate – Lung Fibrosis

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Fellowship – Pulmonary Fibrosis

    University of California, San Francisco – San Francisco, California, United States

    Postdoctoral Fellow – Pulmonary Medicine

    Indiana University – Indiana, Pennsylvania, United States

    Postdoctoral Scientist – Host-Pathogen Interactions in the Human Lung

    Rutgers Health – Newark, New Jersey, United States

    > See All Jobs

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