Nontoxic Impact of PEG-Coated Gold Nanospheres on Functional Pulmonary Surfactant-Secreting Alveolar Type II Cells The present study investigates, for the first time, the impact of polyethyleneglycol (PEG) coated gold nanoparticles on freshly purified primary cultures of rat alveolar type II cells. [Nanotoxicology] Abstract Localized Fgf10 Expression Is Not Required for Lung Branching Morphogenesis but Prevents Differentiation of Epithelial Progenitors Researchers showed that Fgf10 prevents the differentiation of distal epithelial progenitors into Sox2-expressing airway epithelial cells in part by activating epithelial ß-catenin signaling, which negatively regulates Sox2 expression. [Development] Abstract House Dust Mite-Induced Calcium Signaling Instigates Epithelial Barrier Dysfunction and CCL20 Production Scientists investigated the effect of house dust mite on accumulation of intracellular Ca2+ concentration levels, barrier function, and CCL20 release in human bronchial epithelial 16HBE cells and primary bronchial epithelial cells from healthy subjects and asthma patients. [Allergy] Abstract Cytochrome P450 2A13 Is an Efficient Enzyme in Metabolic Activation of Aflatoxin G1 in Human Bronchial Epithelial Cells Human bronchial epithelial cells that stably express cytochrome P450 2A13 were used to conduct the effects of AFG1 on cytotoxicity, apoptosis, DNA damages, and their response protein expression. [Arch Toxicol] Abstract Activation of Autophagy Rescues Amiodarone-Induced Apoptosis of Lung Epithelial Cells and Pulmonary Toxicity in Rats Amiodarone treatment-induced autophagy in H460 human lung epithelial cells and BEAS-2B normal human bronchial epithelial cells was demonstrated by increased LC3-II conversion, Atg7 upregulation, and autophagosome formation. [Toxicol Sci] Abstract LUNG CANCER Notch-1 Contributes to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer In Vitro and In Vivo The exact mechanism of Notch during acquisition of resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) in human lung cancer remains unclear. Researchers showed that the expression of Notch-1 was highly upregulated in EGFR-TKI acquired resistant lung cancer cells. [Eur J Cancer] Abstract Regulation of SIRT2 Levels for Human Non-Small Cell Lung Cancer Therapy Investigators analyzed the expression pattern of sirtuin (SIRT)2 in non-small lung cancer (NSCLC) tissues from clinical patients and in cell lines, and found that SIRT2 was significantly down-regulated at both the mRNA and protein levels in tumor than non-tumor tissues or cells, which were corroborated by the NSCLC tissue microarray results. [Lung Cancer] Abstract Axin Gene Methylation Status Correlates with Radiosensitivity of Lung Cancer Cells After X-ray irradiation, xenograft growth was significantly decreased in H157 cells in comparison with LTE cells. Significantly decreased cell invasiveness and increased apoptosis were also observed in H157 cells treated with X-ray irradiation. [BMC Cancer] Full Article Silibinin Meglumine, a Water-Soluble Form of Milk Thistle Silymarin, Is an Orally Active Anti-Cancer Agent that Impedes the Epithelial-to-Mesenchymal Transition (EMT) in EGFR-Mutant Non-Small-Cell Lung Carcinoma Cells Because the EMT is required by a multiplicity of mechanisms of resistance to EGFR tyrosine kinase inhibitors, scientists evaluated the ability of silibinin meglumine to impede the EMT in vitro and in vivo. [Food Chem Toxicol] Abstract Epithelial Membrane Protein 3 Is Frequently Shown Promoter Methylation and Functions as a Tumor Suppressor Gene in Non-Small Cell Lung Cancer The expression and clinical significance of epithelial membrane protein 3 (EMP3) protein in lung cancer have not yet been elucidated. In vitro, following release from serum starvation of A549 NSCLC cells, the expression of EMP3 was deregulated. [Exp Mol Pathol] Abstract |