Sustained Protein Kinase D Activation Mediates Respiratory Syncytial Virus-Induced Airway Barrier Disruption Investigators studied the effect of Respiratory Syncytial Virus infection on airway epithelial barrier using model epithelia. [J Virol] Abstract Characterization of the Molecular Interplay between Moraxella catarrhalis and Human Respiratory Tract Epithelial Cells By using Tn-seq, a genome-wide negative selection screenings technology, scientists identified 15 genes potentially required for adherence of Moraxella catarrhalis BBH18 to pharyngeal epithelial Detroit 562 and lung epithelial A549 cells. [PLoS One] Full Article A Cellular Pathway Involved in Clara Cell to Alveolar Type II Cell Differentiation after Severe Lung Injury Scientists investigated the cellular pathway underlying the Clara cell to alveolar type 2 (AT2) differentiation. They showed that the initial intermediates are bronchiolar epithelial cells that exhibit Clara cell morphology and express Clara cell marker, Scgb1a1, as well as the AT2 cell marker, pro-surfactant protein C. [PLoS One] Full Article Carcinoembryonic Antigen-Related Cell Adhesion Molecules Are Co-Expressed in the Human Lung and Their Expression Can Be Modulated in Bronchial Epithelial Cells by Non-Typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and Type I and II Interferons In normal human bronchial epithelial cells, mRNA expression of carcinoembryonic antigen-related cell adhesion molecules (CEACAM)1 isoforms CEACAM1-4L, CEACAM1-4S, CEACAM1-3L and CEACAM1-3S were up-regulated by interferons alpha, beta and gamma, as well as the TLR3 agonist polyinosinic:polycytidylic acid. [Respir Res] Abstract | Full Article Mitigation of Radiation-Induced Damage by Targeting EGFR in Noncancerous Human Epithelial Cells Researchers investigated whether methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate mitigates ionizing radiation-induced DNA damage in immortalized normal human colonic epithelial cells and bronchial epithelial cells. [Radiat Res] Abstract LUNG CANCER The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung Cancer Researchers report that SOX2, a self-renewal factor in lung stem/progenitor cells, is highly expressed in a subclass of lung cancer cells, the proliferation, survival and chemoresistance of which are dependent on SOX2 signaling. [Stem Cells] Abstract Enhanced Autophagy Is Required for Survival in EGFR-Independent EGFR-Mutant Lung Adenocarcinoma Cells Researchers demonstrated that two epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma cell lines, HCC827 and HCC4006, contain a subpopulation of cells that have undergone epithelial-to-mesenchymal transition and survive independent of activated EGFR. [Lab Invest] Abstract Enhanced Interaction between Natural Killer Cells and Lung Cancer Cells: Involvement in Gefitinib-Mediated Immunoregulation Gefitinib increased cytotoxicity of natural killer cells to human lung cancer H1975 cells with EGFR L858R + T790M mutations, while not in A549 cells with wild type EGFR. [J Transl Med] Abstract | Full Article Mst1 Overexpression Inhibited the Growth of Human Non-Small Cell Lung Cancer In Vitro and In Vivo Scientists showed that mammalian STE20-like kinase 1 (Mst1) overexpression inhibited cell proliferation and induced apoptosis of A549 cells, promoted Yes-associated protein phosphorylation and downregulated the transcriptional level of Cystein-rich protein connective tissue growth factor, amphiregulin and Survivin. [Cancer Gene Ther] Abstract Suppression of Wnt Signaling by the miR-29 Family Is Mediated by Demethylation of WIF-1 in Non-Small-Cell Lung Cancer Scientists investigated the role of three DNA methyltransferases (DMNTs) in the expression of Wnt inhibitory factor-1 (WIF-1). The three DNA methyltransferases were up-regulated in non-small-cell lung cancer (NSCLC) tumor tissues and suppression of DNMT3A and DNMT3B restored the expression of WIF-1 in NSCLC cells. [Biochem Biophys Res Commun] Abstract |