Rhinovirus-Induced Interferon Production Is Not Deficient in Well Controlled Asthma Human bronchial epithelial cells (HBECs) were obtained from subjects with asthma and healthy controls and infected with rhinovirus (RV)16 and RV1B, and cells and supernatants harvested at 8, 24 and 48 hours. Interferon (IFN)-β and IFN-λ were the only IFNs induced by RV in HBECs and IFN-λ protein induction was substantially greater than IFN-β. [Thorax] Abstract Transcriptional and Epigenetic Modulation of Human Rhinovirus-Induced CXCL10 Production by Cigarette Smoke Scientists used CXCL10 as a model antiviral gene to examine the mechanisms by which cigarette smoke extract inhibits epithelial antiviral immunity. Human rhinovirus (HRV)-induced CXCL10 transcription depends upon activation of nuclear factor-ĸB and IFN regulatory factor-1 and they additionally implicated two signal transducer and activator of transcription consensus sequences in the CXCL10 promoter in HRV-induced CXCL10 expression. [Am J Respir Cell Mol Biol] Abstract Hypercapnic Acidosis Confers Antioxidant and Anti-Apoptosis Effects against Ventilator-Induced Lung Injury Scientists examined the effects of hypercapnic acidosis on the role of apoptosis signal-regulating kinase 1, which activates the c-Jun N-terminal kinase and p38 cascade in both apoptosis and oxidative reactions, in high-pressure ventilation stimulated rat lungs. [Lab Invest] Abstract Identification of SPLUNC1’s ENaC-Inhibitory Domain Yields Novel Strategies to Treat Sodium Hyperabsorption in Cystic Fibrosis Airway Cultures Researchers found that an eighteen amino acid peptide, S18, which corresponded to residues G22-A39 of Short Palate Lung and Nasal Epithelial Clone 1 (SPLUNC1)’s N-terminus inhibited epithelial sodium channel (ENaC) activity to a similar degree as full-length SPLUNC1, whilst SPLUNC1 protein lacking this region was without effect. [Am J Physiol Lung Cell Mol Physiol] Abstract Human Metapneumovirus Inhibits the IL-6-Induced JAK/STAT3 Signaling Cascade in Airway Epithelium Investigators showed that human metapneumovirus (hMPV) can attenuate the interleukin-6 (IL-6) mediated JAK/STAT3 signaling cascade in lung epithelial cells. HMPV inhibited a key event in this pathway by impeding the phosphorylation and nuclear translocation of STAT3 in A549 cells and in primary normal human bronchial epithelial cells. [J Gen Virol] Abstract LUNG CANCER The Use of Hollow Mesoporous Silica Nanospheres to Encapsulate Bortezomib and Improve Efficacy for Non-Small Cell Lung Cancer Therapy Researchers report the application of hollow mesoporous silica nanospheres (HMSNs) in encapsulating bortezomib (BTZ) for drug delivery. In in vitro cell viability assay on human NSCLC H1299 cells, the half-maximum inhibiting concentration of HMSNs-BTZ was 42% of that for free BTZ in 48 hour treatments. [Biomaterials] Abstract IGFBP2/FAK Pathway Is Causally Associated with Dasatinib Resistance in Non-Small Cell Lung Cancer Cells Scientists analyzed the association between IGFBP2 and response to pathway-targeted agents in seven human non-small cell lung cancer cell lines. The results showed that high IGFBP2 levels were associated with resistance to dasatinib, and to a lesser degree to sacaratinib, but not to other agents. [Mol Cancer Ther] Abstract Epigenetic Inactivation of MicroRNA-34b/c Predicts Poor Disease-Free Survival in Early Stage Lung Adenocarcinoma Scientists investigated the clinical implications of microRNA-34b/c (miR-34b/c) methylation in early stage lung adenocarcinoma (AC) patients and to determine the functional role of miR-34b/c re-expression in lung AC cell lines. [Clin Cancer Res] Abstract Gemcitabine Sensitizes Lung Cancer Cells to Fas/FasL System-Mediated Killing Researchers evaluated the Fas/FasL system involvement in gemcitabine-induced lung cancer cell killing. Gemcitabine increased FasL mRNA and total protein expression, the percentage of H292 cells bearing membrane-bound FasL (mFasL) and of mFasL positive apoptotic H292 cells, as well as caspase-8 and-3 cleavage. [Immunology] Abstract Low-Dose Hypersensitivity and Bystander Effect Are Not Mutually Exclusive in A549 Lung Carcinoma Cells after Irradiation with Charged Particles Researchers measured survival fraction of A549 lung carcinoma cells irradiated with charged particles of various linear energy transfer and determined mechanisms responsible for enhanced cell killing in the low-dose region. [Radiat Res] Abstract |