Role of Activin-A in Cigarette Smoke-Induced Inflammation and COPD Researchers studied the effect of cigarette smoke (CS) on primary human bronchial epithelial cells in vitro. Next, activin-A signaling was antagonized in vivo by administration of follistatin in mice exposed to air or CS for 4 weeks. [Eur Respir J] Abstract Early Host Responses of Seasonal and Pandemic Influenza A Viruses in Primary Well-Differentiated Human Lung Epithelial Cells Investigators hypothesized that host responses during infection of well-differentiated, primary human bronchial epithelial cells may differ between seasonal and H1N1 pandemic influenza A virus isolates from a fatal and nonfatal case. [PLoS One] Full Article Autophagy Mediates Avian Influenza H5N1 Pseudotyped Particle-Induced Lung Inflammation through NF-κB and p38 MAPK Signaling Pathways Researchers showed that H5N1 hemagglutinin pseudotyped viral particles significantly induced autophagy both in A549 human lung epithelial cells and in mouse lung tissues, which was primarily due to hemagglutinin of H5N1 virus. [Am J Physiol Lung Cell Mol Physiol] Abstract Characterization of Innate Responses to Influenza Virus Infection in a Novel Lung Type I Epithelial Cell Model Researchers characterized influenza virus replication dynamics and host responses of lung type I epithelial cells and identified the capacity of epithelial cell-derived type I interferon to regulate specific modules of antiviral effectors to establish an effective antiviral state. [J Gen Virol] Abstract LUNG CANCER Ras Regulates Kinesin 13 Family Members to Control Cell Migration Pathways in Transformed Human Bronchial Epithelial Cells Scientists showed that expression of the microtubule depolymerizing kinesin KIF2C is induced by transformation of immortalized human bronchial epithelial cells by expression of K-RasG12V and knockdown of p53. [Oncogene] Abstract A Novel Molecular Pathway for Snail-Dependent, SPARC-Mediated Invasion in Non-Small Cell Lung Cancer Pathogenesis Treatment of human bronchial epithelial cell lines with TGF-β1 and inhibition of TGF-β1 mRNA expression modulated Secreted Protein, Acidic and Rich in Cysteine (SPARC) expression. Inhibition of MEK phosphorylation downregulated SPARC. [Cancer Prev Res] Abstract Epigenetic Regulation of ANKRD18B in Lung Cancer ANKRD18B mRNA expression was significantly decreased or silenced in lung cancer tissues and cell lines associated with hypermethylation of the ANKRD18B region. Demethylation agent 5-aza-2′-deoxycytidine significantly increased ANKRD18B mRNA expression in lung cancer cell lines. [Mol Carcinog] Abstract Diversin Increases the Proliferation and Invasion Ability of Non-Small-Cell Lung Cancer Cells via JNK Pathway Researchers found that Diversin was overexpressed in non-small-cell lung cancer, and exhibited direct correlation to poor differentiation, advanced TNM stage, lymph node metastasis and survival time. [Cancer Lett] Abstract Combination of Liquiritin, Isoliquiritin and Isoliquirigenin Induce Apoptotic Cell Death through Upregulating p53 and p21 in the A549 Non-Small Cell Lung Cancer Cells Scientists evaluated the cytotoxicity and antitumor activity of liquiritin, isoliquiritin and isoliquirigenin on human non-small lung cancer cells including apoptosis-induction, inhibition of apoptotic pathways and to explore the underlying mechanism. [Oncol Rep] Abstract |