Combined Inhaled Salbutamol and Mannitol Therapy for Mucus Hyper-Secretion in Pulmonary Diseases Researchers focused on the co-engineering of salbutamol sulphate, a common bronchodilator, and mannitol, a mucolytic, as a potential combination therapy for mucus hypersecretion. [AAPS J] Abstract Protective Effects of KGF-2 on Ischemia/Reperfusion-Induced Lung Injury in Rats Researchers investigated the potential effects of keratinocyte growth factor-2 (KGF-2) on ischemia/reperfusion-induced lung injury in rats and the related mechanisms. [Am J Respir Cell Mol Biol] Abstract Nuclear Localization of VEGF-D and Regulation of c-Myc-Dependent Transcripts in Human Lung Fibroblasts Investigators report that, independent of its cell surface receptors, full-length vascular endothelial growth factor-D (VEGF-D) accumulated in nuclei of fibroblasts and that this process appears to increase with cell density. [Am J Respir Cell Mol Biol] Abstract TNF-α Induces Cytosolic Phospholipase A2 Expression via Jak2/PDGFR-Dependent Elk-1/p300 Activation in Human Lung Epithelial Cells Researchers demonstrated that tumor necrosis factor-α (TNF-α) induced cytosolic phospholipase A2 (cPLA2) mRNA and protein expression, promoter activity, and prostaglandin E2 secretion in human lung epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract Amiloride-Sensitive Fluid Resorption in NCI-H441 Lung Epithelia Depends on an Apical Cl– Conductance Researchers demonstrated that water resorption depends on epithelial sodium channel (ENaC), and cystic fibrosis transmembrane regulator (CFTR) channels have only a minor but probably modulating effect on water resorption. However, the major ENaC-mediated water resorption depends on an apical non-CFTR Cl– conductance. [Physiol Rep] Full Article Fluticasone Furoate Is More Effective than Mometasone Furoate in Restoring Tobacco Smoke Inhibited SOCS-3 Expression in Airway Epithelial Cells The authors compared the effect of fluticasone furoate with mometasone furoate on cytokine signaling-3 (SOCS-3) expression in tobacco smoke exposed BAEpCs in vitro and in a mouse model of chronic obstructive pulmonary disease in vivo. [Int Immunopharmacol] Full Article LUNG CANCER A Dual Role for Autophagy in a Murine Model of Lung Cancer Researchers report that tissue-specific inactivation of Atg5, essential for the formation of autophagosomes, markedly impairs the progression of KRasG12D-driven lung cancer, resulting in a significant survival advantage of tumor-bearing mice. [Nat Commun] Abstract Loss of LKB1 Promotes CXCL8 Production via NF-κB and WNT Signaling in Human Bronchial Epithelial Cells Investigators utilized human bronchial epithelial cells immortalized in the absence of viral onco-proteins that represent a useful model to study the early events of lung carcinogenesis. [Clin Cancer Res] Abstract A Multicenter Phase II Study of Sorafenib Monotherapy in Clinically Selected Patients with Advanced Lung Adenocarcinoma after Failure of EGFR-TKI Therapy The authors investigated the efficacy and safety of sorafenib in patients with advanced lung adenocarcinoma after failure of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) therapy. [Lung Cancer] Abstract |