Thrombin Induces ICAM-1 Expression in Human Lung Epithelial Cells via c-Src/PDGFR/PI3K/Akt-Dependent NF-?B/p300 Activation The mechanisms underlying thrombin-induced intercellular adhesion molecule-1 (ICAM-1) expression in human pulmonary alveolar epithelial cells (HPAEpiCs) remain unclear. Researchers showed that thrombin induced ICAM-1 expression in HPAEpiCs. [Clin Sci] Abstract Antifibrotic Effects of Noscapine through Activation of Prostaglandin E2 Receptors and Protein Kinase A Researchers examined the potential antifibrotic effects of the antitussive drug, noscapine, recently found to bind microtubules and affect microtubule dynamics. Noscapine did not activate protein kinase A in human bronchial or alveolar epithelial cells. [J Biol Chem] Abstract | Full Article Cigarette Smoke-Induced Alveolar Epithelial-Mesenchymal Transition Is Mediated by Rac1 Activation Epithelial-mesenchymal transition was induced in mice and pulmonary epithelial cells by exposure of cigarette smoke and cigarette smoke extract (CSE) respectively. Treatment of pulmonary epithelial cells with CSE elevated Rac1 expression associated with increased TGF-ß1 release. [Biochim Biophys Acta] Abstract Activation of Transcription Factor Nrf2 Signaling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers Nuclear factor erythroid 2-related factor 2 (Nrf2) was stabilized by SKI-II (2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole), which is a known sphingosine kinase inhibitor, in the human bronchial epithelial cell line, BEAS2B, and in primary human bronchial epithelial cells, leading to enhancement of anti-oxidant proteins, such as HO-1, NQO1 and GCLM. [PLoS One] Full Article Activated Alveolar Epithelial Cells Initiate Fibrosis through Autocrine and Paracrine Secretion of Connective Tissue Growth Factor Scientists found that alveolar epithelial cells undergoing TGFß-mediated mesenchymal transition in vitro were also capable of activating lung fibroblasts through production of connective tissue growth factor. [Am J Physiol Lung Cell Mol Physiol] Abstract mTOR Inhibition of Cardamonin on Antiproliferation of A549 Cells Is Involved in a FK506 Binding Protein Independent Fashion The antiproliferative effect and the possible mechanism of combining with mammalian target of rapamycin (mTOR) of cardamonin were investigated on A549 cells. Treated with cardamonin, the proliferation of A549 cells was inhibited. [Life Sci] Abstract LUNG CANCER MicroRNA-545 Suppresses Cell Proliferation by Targeting Cyclin D1 and CDK4 in Lung Cancer Cells Researchers found that microRNA (miR)-545 was less abundant in cancerous lung tissues than in adjacent non-cancerous tissues. Further studies showed that miR-545 suppressed cell proliferation in vitro and in vivo. [PLoS One] Full Article PKCd/Midkine Pathway Drives Hypoxia-Induced Proliferation and Differentiation of Human Lung Epithelial Cells Replication of human lung epithelial cells was significantly increased by chronic hypoxia and was dependent on expression of protein kinase C (PKC)d. Hypoxia-induced proliferation of epithelial cells was accompanied by translocation of PKCd from Golgi into the nuclei. [Am J Physiol Lung Cell Mol Physiol] Abstract Microvesicle-Associated MicroRNA Expression Is Altered upon Particulate Matter Exposure in Healthy Workers and in A549 Cells Scientists evaluated expression of microRNAs (miR) contained within plasma microvesicles (MVs) upon particulate matter (PM) exposure both in vivo and in vitro. In vitro experiments confirmed a dose-dependent expression of miR-128 in MVs released from A549 cells after six?hours of PM treatment. [J Appl Toxicol] Full Article Propofol Induces Endoplasmic Reticulum (ER) Stress and Apoptosis in Lung Cancer Cell H460 Researchers demonstrated the effects of propofol on the proliferation and the apoptosis of lung cancer cell H460 by using colony formation assay and flow cytometry. [Tumor Biol] Abstract Win a $25 Amazon Gift Card! Connexon Creative is evaluating reader interest in a new social media platform. Fill out this quick survey for your chance to win 1 of 4 $25 gift cards! Take survey here |