Particulate Nature of Inhaled Zinc Oxide Nanoparticles Determines Systemic Effects and Mechanisms of Pulmonary Inflammation in Mice Because zinc ions may be involved in the toxicity of zinc oxide nanoparticles (ZnONP), investigators compared adverse effects of inhaled aerosolized ZnONP and zinc nitrate in mice. [Nanotoxicology] Abstract Autocrine Ligands of the Epithelial Growth Factor Receptor Mediate Inflammatory Responses to Diesel Exhaust Particles As cigarette smoke-induced IL-8 expression by epithelial cells involves transactivation of the epidermal growth factor receptor (EGFR), scientists studied the effects of diesel exhaust particles on IL-8 release and the role of the EGFR. [Resp Res] Abstract | Full Article The Progression of Comorbidity in IL-18 Transgenic Chronic Obstructive Pulmonary Disease Mice Model The authors previously reported a new mouse model of chronic obstructive pulmonary disease (COPD) utilizing the human surfactant protein C promoter SP-C to drive the expression of mature mouse IL-18 cDNA; constitutive IL-18 overproduction in the lungs of transgenic mice induces severe emphysematous change, dilatation of the right ventricle, and mild pulmonary hypertension with aging. They evaluated the progression of comorbidity in their COPD model. [Biochem Biophys Res Commun] Abstract Transcriptional and Posttranscriptional Regulation and Endocytosis Were Involved in Zinc Oxide Nanoparticle-Induced Interleukin-8 Overexpression in Human Bronchial Epithelial Cells The mechanisms underlying zinc oxide nanoparticles (ZnO-NPs)-induced interleukin 8 (IL-8) gene expression have not been fully characterized. The transcription inhibitor actinomycin D and the BEAS-2B cells stably overexpressing wild-type or mutated IL-8 promoter at the NFκB or C/EBPβ binding site were used to determine the involvement of transcriptional mechanisms. [Cell Biol Toxicol] Abstract LUNG CANCER miR-142-3p Represses TGF-β-Induced Growth Inhibition through Repression of TGFβR1 in Non-Small Cell Lung Cancer Researchers investigated the function and regulation of TGF-β signaling-based miRNAs in non-small cell lung cancer. Computational algorithms predicted that the 3′-untranslated region (3′-UTR) of TGFβR1 is a target of miR-142-3p. A luciferase reporter assay confirmed that miR-142-3p can directly bind to 3′-UTR of TGFβR1. [FASEB J] Abstract cAMP Signaling Inhibits Radiation-Induced ATM Phosphorylation Leading to the Augmentation of Apoptosis in Human Lung Cancer Cells Scientists investigated the mechanism through which cAMP signaling regulates ataxia-telangiectasia mutated (ATM) activation and cellular responses to ionizing radiation in lung cancer cells. [Mol Cancer] Abstract | Full Article Downregulation of HOXA1 Gene Affects Small Cell Lung Cancer Cell Survival and Chemoresistance under the Regulation of miR-100 Scientists aimed to characterize the clinical significance and functional roles of HOXA1 in small cell lung cancer (SCLC). Expression of HOXA1 was examined in 63 cases of SCLC tissues and 29 cases of blood by immunohistochemistry and quantitative reverse transcription-polymerase chain reaction methods. [Eur J Cancer] Abstract TRAP1 Regulates Proliferation, Mitochondrial Function and Has Prognostic Significance in NSCLC The effect of tumor necrosis factor receptor-associated protein 1 (TRAP1) ablation on cell proliferation, survival, apoptosis and mitochondrial function was determined in non-small cell lung cancer (NSCLC). [Mol Cancer Res] Abstract |