Synergy-Based Small-Molecule Screen Using a Human Lung Epithelial Cell Line Yields ΔF508-CFTR Correctors that Augment VX-809 Maximal Efficacy The most prevalent CFTR mutation causing cystic fibrosis, ΔF508, impairs folding of nucleotide binding domain 1 (NBD1) and stability of the interface between NBD1 and the membrane spanning domains. The interfacial stability defect can be partially corrected by the investigational drug VX-809 or the R1070W mutation. Investigators postulated that a second corrector targeting a distinct folding/interfacial defect might act in synergy with VX-809 or the R1070W suppressor mutation. [Mol Pharmacol] Abstract | Full Article Modeling Nanoparticle-Alveolar Epithelial Cell Interactions under Breathing Conditions Using Captive Bubble Surfactometry Researchers present a method where epithelial lung cells are integrated into a system, the Captive Bubble Surfactometer, which allows the cyclical compression and expansion of the surfactant film at the air-liquid interface, thus modelling the dynamics of breathing. [Langmuir] Abstract Staphylococcus aureus Alpha-Toxin Mediates General and Cell Type-Specific Changes in Metabolite Concentrations of Immortalized Human Airway Epithelial Cells Using 1H-NMR, GC-MS and HPLC-MS, investogators quantified the concentrations of 51 intracellular metabolites and assessed alterations in the amount of 25 extracellular metabolites in the two human bronchial epithelial cell lines S9 and 16HBE14o− under standard culture conditions and after treatment with sub-lethal amounts (2 µg/ml) of recombinant Staphylococcus aureus alpha-toxin in a time-dependent manner. [PLoS One] Full Article Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-Cadherin, LKB1, and AMPK Scientists showed that Birt-Hogg-Dubé lungs exhibit increased alveolar epithelial cell apoptosis and that folliculin deletion in mouse lung epithelium leads to cell apoptosis, alveolar enlargement, and an impairment of both epithelial barrier and overall lung function. [Cell Rep] Abstract | Full Article | Press Release LUNG CANCER Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells Investigators used an inducible murine model and demonstrate that inactivation of lactate dehydrogenase-A in mouse models of NSCLC driven by oncogenic K-RAS or EGFR leads to decreased tumorigenesis and disease regression in established tumors. [Cell Metab] Abstract | Graphical Abstract | Press Release Clinical Outcome According to the Level of Preexisting Epidermal Growth Factor Receptor T790M Mutation in Patients with Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. Researchers evaluated whether the clinical outcomes are affected by the percentage of preexisting T790M mutations within a tumor. [Cancer] Abstract The Bim Deletion Polymorphism Clinical Profile and Its Relation with Tyrosine Kinase Inhibitor Resistance in Chinese Patients with Non-Small Cell Lung Cancer Investigators retrospectively studied the Bim deletion polymorphism in Chinese patients with non-small cell lung cancer and its correlation with the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors. [Cancer] Abstract TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression In lung cancer progression, p53 mutations are more often observed in invasive tumors than in noninvasive tumors, suggesting that p53 is involved in tumor invasion and metastasis. Scientists report that KRAS activation induces epithelial-mesenchymal transition and that p53 inactivation is required for cell motility and invasiveness. [Cell Rep] Abstract | Full Article | Graphical Abstract |