PEGylation of ORMOSIL Nanoparticles Differently Modulates the In Vitro Toxicity toward Human Lung Cells Researchers studied the in vitro responses to ORganically MOdified SILica (ORMOSIL) nanoparticles (NPs) in different types of human lung cells to determine the effects of polyethylene glycol (PEG) coating on NP cytotoxicity. [Arch Toxicol] Abstract MiRNA-21/DDAH1 Pathway Regulates Pulmonary Vascular Responses to Hypoxia Researchers studied the potential role of miRNA-21 in the regulation of hypoxia-induced changes in asymmetric dimethylarginine (ADMA) metabolism in vitro and in vivo. Hypoxia inhibited dimethylarginine dimethylaminohydrolase (DDAH)1 and DDAH2 expression and increased ADMA levels in cultured human pulmonary endothelial cells. [Biochem J] Abstract Intracellular Transport of Nanodiamond Particles in Human Endothelial and Epithelial Cells Scientists examined the penetration human umbilical cord endothelial cells and A549 cells by detonation nanodiamonds modified by adding to, employing four pharmacological inhibitors of endocytosis, using optical, confocal and transmission electron microscopy. [Chem Biol Interact] Abstract Oxidative Stress Modulates the Expression of Genes Involved in Cell Survival in ΔF508 Cystic Fibrosis Airway Epithelial Cells Investigators compared the gene expression profile in NuLi-1 cells, with wild-type cystic fibrosis transmembrane conductance regulator and CuFi-1 cells homozygous for ΔF508 mutation cultured at air-liquid interface. [Physiol Genomics] Abstract Magnolol Inhibits Tumor Necrosis Factor-α-Induced ICAM-1 Expression via Suppressing NF-κB and MAPK Signaling Pathways in Human Lung Epithelial Cells Scientists examined the effects of magnolol on tumor necrosis factor-α-induced upregulation of intercellular adhesion molecule-1 (ICAM-1), activation of the nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling pathway in cultured human pulmonary epithelial cells, and adhesion of human macrophage-like U937 cells to A549 cells. [Inflammation] Abstract Inhibition of Pseudomonas aeruginosa PAO1 Adhesion to and Invasion of A549 Lung Epithelial Cells by Natural Extracts Using an A549 lung epithelial cell infection model researchers revealed that a combination of aqueous cranberry extract with ciprofloxacin could completely prevent the adhesion and invasion of P. aeruginosa PAO1 compared to the untreated control. [J Infect Public Health] Abstract LUNG CANCER Epigenetic Reprogramming of Human Lung Cancer Cells with the Extract of Bovine Parthenogenetic Oocytes Researchers investigated whether cancer cells can be epigenetically reprogrammed by oocyte extract. H460 human lung cancer cells were reversibly permeabilized and incubated with the extract of bovine parthenogenetic oocytes. [J Cell Mol Med] Full Article CXCL16 and CXCR6 Are Coexpressed in Human Lung Cancer In Vivo and Mediate the Invasion of Lung Cancer Cell Lines In Vitro Scientists explored the significance of CXCL16-CXCR6 axis in the biological functions of lung cancer cell lines in vitro. It was found that CXCL16 had no effects on the proliferating cell nuclear antigen expression of A549, 95D and H292 cells. [PLoS One] Full Article Tanshinone IIA Induces Cytochrome C-Mediated Caspase Cascade Apoptosis in A549 Human Lung Cancer Cells via the JNK Pathway The in vitro effects of tanshinone IIA (TSIIA) on apoptosis were investigated in A549 non-small cell lung cancer cells. Researchers showed that TSIIA significantly suppressed the proliferation of A549 cells in a dose-dependent manner. [Int J Oncol] Abstract Knockdown of Toll-Like Receptor 4 Inhibits Human NSCLC Cancer Cell Growth and Inflammatory Cytokine Secretion In Vitro and In Vivo Scientists sought to characterize the expression of toll-like receptor 4 (TLR4) in patients with non-small cell lung cancer (NSCLC) and investigated the biological roles of TLR4 in lung metastasis, cell invasion and survival. [Int J Oncol] Abstract miR-186 Targets ROCK1 to Suppress the Growth and Metastasis of NSCLC Cells Researchers identified microRNA (miR)-186 as a tumor suppressor in non-small cell lung cancer (NSCLC), which was decreased in NSCLC. Overexpression of miR-186 significantly inhibited proliferation, migration, and invasion of NSCLC cells. [Tumor Biol] Abstract |