Pulmonary Cell News Volume 3.28 | Jul 24 2014

Respiratory Syncytial Virus Can Infect Basal Cells and Alter Human Airway Epithelial Differentiation
Using either mechanical or chemical injury models, scientists demonstrate a robust respiratory syncytial virus infection of p63⁺ basal cells in air-liquid interface cultures of human bronchial epithelial cells. [PLoS One]
Full Article

Mucin 1 (MUC1) Signaling Contributes to Increase the Resistance to Cell Death in Human Bronchial Epithelial Cells Exposed to Nickel Acetate
Since ErbBs are closely associated to MUC1, a glycoprotein component of airway mucus that is overexpressed in lung tumors, researchers investigated the role of this signaling system in the survival response of airway epithelial cells against nickel acetate-induced cell death. [Biometals] Abstract

Functional and Pharmacological Characterization of Volume-Regulated Anion Channels in Human Normal and Cystic Fibrosis Bronchial and Nasal Epithelial Cells
Scientists compared the biophysical features and pharmacological profiles of volume-regulated anion channels currents in healthy and cystic fibrosis respiratory epithelial cells in order to characterize these currents both functionally and pharmacologically. [Eur J Pharmacol] Abstract

Genotypically Defined β-Lactamase Negative Ampicillin Resistant Isolates of Non-Typeable Haemophilus influenzae Are Associated with Increased Invasion of Bronchial Epithelial Cells In Vitro
Scientists investigated the association between the presence of altered penicillin binding protein 3 in non-typeable H. influenzae and an increased capacity to invade bronchial epithelial cells in vitro. [J Med Microbiol] Abstract

LUNG CANCER

Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro
Researchers found that multiple nuclear factor erythroid-2 related factor2 (Nrf2) target genes showed high expression in CBP501-insensitive cell lines. Western blot and immunocytochemical analysis for Nrf2 in non-small cell lung cancer (NSCLC) cell lines also indicated higher protein level in CBP501 insensitive cell lines. [Mol Cancer Ther] Abstract

Effects of Lentivirus-Mediated RNAi Knockdown of NEDD9 on Human Lung Adenocarcinoma Cells In Vitro and In Vivo
Scientists investigated the biological behavior of lung adenocarcinoma A549 cells following transfection with NEDD9-specific lentiviral particles in vitro and in vivo. [Oncol Rep] Abstract

Immunomodulatory Effect of Melatonin in SK-LU-1 Human Lung Adenocarcinoma Cells Co-Cultured with Peripheral Blood Mononuclear Cells
Under co-culture conditions, increases in apoptotic cell death, increase in oxidative stress by reduction of glutathione and cell cycle arrest in G₀/G₁ in SK-LU-1 cells, were observed as the immunomodulatory effect of melatonin. [Cell Prolif] Abstract

Fibroblast Growth Factor-Inducible 14 Regulates Cell Growth and Multidrug Resistance of Small-Cell Lung Cancer through the Nuclear Factor-κB Pathway
Expression of fibroblast growth factor-inducible 14 (Fn14) was examined in 51 cases of small-cell lung cancer (SCLC) tissues by immunohistochemistry. Overexpression or knockdown of Fn14 was carried out in SCLC multidrug-resistant cell lines and the parental cell lines to assess its influence on cell growth and chemoresistance. [Anticancer Drugs] Abstract

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New Clinical Study Aims to Investigate the Genomics of Young Lung Cancer
The Addario Lung Cancer Medical Institute launched a new study, the Genomics of Young Lung Cancer, to understand why lung cancer occurs in young adults, who are athletic, never smokers and do not exhibit any of the known lung cancer genetic mutations. [The Bonnie J. Addario Lung Cancer Foundation]
Press Release

Pulmonary Fibrosis Foundation Disease Education Webinars Focus on Pulmonary Rehabilitation and the FDA’s Breakthrough Drug Therapy Designation
The Pulmonary Fibrosis Foundation announced two upcoming webinars, one of which is related to the U.S. Food and Drug Administration (FDA) granting breakthrough therapy designation for two new investigational treatments for idiopathic pulmonary fibrosis. [Pulmonary Fibrosis Foundation] Press Release

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