Myb Permits Multilineage Airway Epithelial Cell Differentiation Researchers identified transcription factor Myb as a key regulator that permits early multilineage differentiation of airway epithelial cells. Myb+ cells were identified as p63– and therefore distinct from basal progenitor cells, but were still negative for markers of differentiation. [Stem Cells] Abstract Elimination of B-RAF in Oncogenic C-RAF-Expressing Alveolar Epithelial Type II Cells Reduces MAPK Signal Intensity and Lung Tumor Growth Scientists describe a new mouse model for lung tumor development to investigate the role of B-RAF in oncogenic C-RAF-mediated adenoma initiation and growth. Conditional elimination of B-RAF in C-RAF BxB-expressing embryonic alveolar epithelial type II cells did not block adenoma formation. However, loss of B-RAF led to significantly reduced tumor growth. [J Biol Chem] Abstract | Full Article TRIM72 Is Required for Effective Repair of Alveolar Epithelial Cell Wounding Investigators characterized tripartite motif protein 72 (TRIM72) expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract Particle Pollution in Rio de Janeiro, Brazil: Increase and Decrease of Pro-Inflammatory Cytokines IL-6 and IL-8 in Human Lung Cells Particle pollution from urban and industrialized regions in Rio de Janeiro, Brazil was analyzed for toxic and pro-inflammatory responses in human bronchial epithelial cells. [Environ Pollut] Abstract Whole Genome Expression Analysis in Primary Bronchial Epithelial Cells after Exposure to Sulfur Mustard To gain a better understanding of the mechanism of sulfur mustard (SM) toxicity, researchers investigated whole genome transcriptional changes after SM in primary human bronchial epithelial cells, as a model for inhalation exposure. [Toxicol Lett] Abstract Brief Exposure to Cigarette Smoke Impairs Airway Epithelial Cell Innate Anti-Viral Defense Researchers determined the impact of short-term exposure to cigarette smoke on innate immune responses of airway epithelial cells infected with human rhinovirus. [Toxicol In Vitro] Abstract LUNG CANCER MicroRNA-26a/b Regulate DNA Replication Licensing, Tumorigenesis and Prognosis by Targeting CDC6 in Lung Cancer Scientists demonstrate that microRNA (miR)-26a and miR-26b inhibit replication licensing and the proliferation, migration and invasion of lung cancer cells by targeting CDC6. [Mol Cancer Res] Abstract MicroRNA-493 Suppresses Tumor Growth, Invasion and Metastasis of Lung Cancer by Regulating E2F1 Scientists investigated the role and mechanism of microRNA (miR)-493 in the development and progression of nonsmall-cell lung cancer. The ectopic expression of miR-493 impaired cell growth and invasion in vitro and in vivo. [PLoS One] Full Article Differential Knockdown of TGF-β Ligands in a Three-Dimensional Co-Culture Tumor-Stromal Interaction Model of Lung Cancer Scientists employed a model to examine how knockdown of transforming growth factor (TGF)-β ligands affects the behavior of different cell types. They developed lentivirus vectors carrying artificial microRNAs against human TGF-β1 and TGF-β2, and tested their effects in lung cancer cells and fibroblasts. [BMC Cancer] Full Article Betulin Inhibits Lung Carcinoma Proliferation through Activation of AMPK Signaling Betulin is an abundant, naturally occurring triterpene. Investigators reveal its antiproliferative effects and mechanisms using two lung carcinoma cells (A549 and NCI-292). [Tumor Biol] Abstract |