Long-Term Survival of Influenza Virus Infected Club Cells Drives Immunopathology Scientists propose a model in which infected, surviving club cells establish a proinflammatory environment aimed at controlling virus levels, but at the same time contribute to lung pathology. [J Exp Med] Abstract | Press Release IL-6/STAT3 Promotes Regeneration of Airway Ciliated Cells from Basal Stem Cells Using a clonal 3D organoid assay, investigators found that IL-6 stimulated, and Stat3 inhibitors reduced, the generation of ciliated vs. secretory cells from basal cells. [Proc Natl Acad Sci USA] Abstract | Full Article CCN1 Secretion and Cleavage Regulate the Lung Epithelial Cell Functions after Cigarette Smoke Scientists report a novel paradigm potentially involved in the development of epithelial cell death and tissue loss in cigarette smoking-associated emphysema. [Am J Physiol Lung Cell Mol Physiol] Full Article A New 9-Alkyladenine-Cyclic Methylglyoxal Diadduct Activates Wt- and F508del-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) In Vitro and In Vivo Investigators report on the synthesis of 9-alkyladenine derivatives and analogues of their previously discovered activator of wt-CFTR and F508del-CFTR, GPact-11a, and the identification of a new activator of these channels, GPact-26a, through various flux assays on human airway epithelial CF and non-CF cell lines and in vivo measurement of rat salivary secretion. [Eur J Med Chem] Abstract | Graphical Abstract Indacaterol Inhibits the Tumor Cell Invasiveness and the Expression of MMP-9 by Suppressing IKK/NF-KappaB Activation Researchers showed that indacaterol significantly inhibited TNF-α/NF-κB-induced cell invasiveness and migration in a human cancer cell line and propose that indacaterol may inhibit NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in chronic obstructive pulmonary disorder patients. [Mol Cells] Abstract | Full Article Secretoglobin 3A2 Attenuates Lipopolysaccharide-Induced Inflammation through Inhibition of ERK and JNK Pathways in Bronchial Epithelial Cells Scientists demonstrate the novel biological activity of secretoglobin 3A2, which attenuated lipopolysaccharide-induced inflammation in bronchial epithelial cells through inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation. [Inflammation] Abstract LUNG CANCER The Inhibitor of Kappa B Kinase-Epsilon Regulates MMP-3 Expression Levels and Can Promote Lung Metastasis Researchers report that lung carcinoma cells ectopically expressing high levels of the receptor for the type I insulin like growth factor receptor (M27R cells) had a significant reduction in matrix metalloproteinases (MMP)-3 expression levels and this coincided with reduced metastasis to the lung. [Oncogenesis] Full Article TIP30 Nuclear Translocation Negatively Regulates EGF-Dependent Cyclin d1 Transcription in Human Lung Adenocarcinoma Investigators demonstrate that TIP30, a tumor suppressor protein, translocated into the nucleus of human lung adenocarcinoma cells following epidermal growth factor (EGF) treatment, and the selective inhibitors of EGFR signaling pathways blocked this effect. [Cancer Lett] Abstract Singly Protonated Dehydronorcantharidin Silver Coordination Polymer Induces Apoptosis of Lung Cancer Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway Researchers provide evidence that Ag-SP-DNC, a novel silver and singly protonated dehydronorcantharidin complex, elicits a reactive oxygen species-mediated mitochondrial apoptosis in lung cancer cells. [Eur J Med Chem] Abstract | Graphical Abstract Crotoxin Induces Apoptosis and Autophagy in Human Lung Carcinoma Cells In Vitro via Activation of the p38MAPK Signaling Pathway Investigators tested human lung squamous carcinoma SK-MES-1 cells and then evaluated the cytotoxicity of crotoxin in both MTT and colony formation assays. [Acta Pharmacol Sin] Abstract |