IL-27 and Type 2 Immunity in Asthmatic Patients: Association with Severity, CXCL9, and Signal Transducer and Activator of Transcription Signaling Investigators evaluated IL-27 expression in human asthma alone and in combination with type 2 immunity to determine the relationship to disease severity and CXCL9 expression. They also modeled these interactions in vitro in human bronchial epithelial cells. [J Allergy Clin Immunol] Full Article D Prostanoid Receptor 2 (Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells) Protein Expression in Asthmatic Patients and Its Effects on Bronchial Epithelial Cells Researchers investigated the bronchial submucosal D prostanoid receptor 2 expression in asthmatic patients and healthy control subjects and explored its functional role in epithelial cells. [J Allergy Clin Immunol] Full Article Src-Mediated EGF Receptor Activation Regulates Ozone-Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells Scientists examined the role of epidermal growth factor (EGF) receptor activation in ozone-induced expression of the chemokine interleukin 8 in human bronchial epithelial cells. [Environ Health Perspect] Abstract | Full Article High Basal Expression of Interferon-Stimulated Genes in Human Bronchial Epithelial (BEAS-2B) Cells Contributes to Influenza A Virus Resistance Investigators compared replication kinetics of human H1N1 (A/USSR/77) influenza A viruses (IAVs) in normal primary human bronchial epithelial and two commonly used respiratory epithelial cell lines namely BEAS-2B and A549 cells. They found that IAV replication was distinctly poor in BEAS-2B cells in comparison with normal primary human bronchial epithelial, A549 and Madin-Darby canine kidney cells. [PLoS One] Full Article Novel Peptide for Attenuation of Hyperoxia-Induced Disruption of Lung Endothelial Barrier and Pulmonary Edema via Modulating Peroxynitrite Formation Researchers found that exposure of pulmonary artery endothelial cells to hyperoxia (95% oxygen and 5% CO2) for 48 hours resulted in disruption of monolayer barrier integrity in a manner of two phases, and apoptosis occurred in the second phase. [J Biol Chem] Abstract | Full Article Identification of a Proximal Progenitor Population from Murine Fetal Lungs with Clonogenic and Multilineage Differentiation Potential Using a Nkx2-1mCherry reporter mouse, researchers have identified and captured Nkx2-1-expressing lung progenitor cells from the proximal lung epithelium during fetal development. These cells formed clonal spheres in semisolid culture that could be maintained in vitro and demonstrated self-renewal and expansion capabilities over multiple passages. [Stem Cell Rep] Full Article LUNG CANCER Specific Expression of OATPs in Primary Small Cell Lung Cancer (SCLC) Cells as Novel Biomarkers for Diagnosis and Therapy The expression of organic anion transporting polypeptides (OATPs) was elucidated in cell lines from small cell lung cancer (SCLC) and lung carcinoids and in paraffin-embedded samples from primary and metastatic SCLCs. Scientists found a strong relationship between OATP expression and the origin of the cells, as cells from primary or metastatic SCLC and carcinoid tumors differ with respect to OATP levels. [Cancer Lett] Abstract Waltonitone Induces Apoptosis through Mir-663-Induced Bcl-2 Downregulation in Non-Small Cell Lung Cancer Investigators treated H460 and H3255 lung cancer cells using different concentration of waltonitone. They observed that waltonitone inhibited cell viability and induced apoptosis in a concentration dependent manner, with upregulation of caspase-3 cleavage. They also observed upregulation of miR-663, a potential tumor suppressor, after waltonitone treatment. [Tumor Biology] Abstract |