Pulmonary Cell News Volume 3.44 | Nov 13 2014

The Secretome of Induced Pluripotent Stem Cells Reduces Lung Fibrosis in Part by Hepatocyte Growth Factor
Scientists evaluated the potential of induced pluripotent stem cell conditioned media to regenerate and repair the alveolar epithelium in vitro and improve bleomycin induced lung injury in vivo. [Stem Cell Res Ther] Abstract | Full Article

A Physiologically-Motivated Compartment-Based Model of the Effect of Inhaled Hypertonic Saline on Mucociliary Clearance and Liquid Transport in Cystic Fibrosis
Scientists present a compartment-based mathematical model of the airway that extends the resolution of functional imaging data. They also utilized a novel imaging metric in vitro to gauge the fraction of airway epithelial cells that have functional ciliary activity. [PLoS One] Full Article

Resveratrol Exerts an Anti-Apoptotic Effect on Human Bronchial Epithelial Cells Undergoing Cigarette Smoke Exposure
Scientists produced a cigarette smoke extract-induced apoptosis human bronchial epithelial cell model to investigate the protective effects of resveratrol. [Mol Med Rep] Abstract

LUNG CANCER

Angiomotin Decreases Lung Cancer Progression by Sequestering Oncogenic YAP/TAZ and Decreasing Cyr61 Expression
Scientists identified the patho-physiological characteristics of angiomotin (AMOT) in lung cancer progression. Knockdown of AMOT in a low metastatic CL1-0 lung cancer cell line initiated cancer proliferation, migration, invasion and epithelial-mesenchymal transition. [Oncogene] Abstract

Metformin and Salinomycin as the Best Combination for the Eradication of NSCLC Monolayer Cells and Their Alveospheres (Cancer Stem Cells) Irrespective of EGFR, KRAS, EML4/ALK and LKB1 Status
After screening of chemotherapeutic agents, tyrosine kinase inhibitors or monoclonal antibody in combination with the putative stem cell killer salinomycin (SAL), scientists found metformin, which modestly exerted a growth inhibitory effect on monolayer cells and alveospheres/cancer stem cells of five NSCLC cell lines regardless of their EGFR, KRAS, EML4/ALK and LKB1 status, interacted synergistically with SAL to effectively promote cell death. [Oncotarget] Full Article

Inhibition of β-Catenin Enhances the Anticancer Effect of Irreversible EGFR-TKI in EGFR-Mutated Non-Small Cell Lung Cancer with a T790M Mutation
Researchers found that epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) cell lines exhibited a high expression level of β-catenin, compared with cell lines with the wild-type EGFR gene, and XAV939 enhanced the sensitivities to EGFR-tyrosine kinase inhibitor (TKI) in EGFR-mutated NSCLC cell lines. [J Thorac Oncol] Abstract

The Combination of Irreversible EGFR TKIs and SAHA Induces Apoptosis and Autophagy-Mediated Cell Death to Overcome Acquired Resistance in EGFR T790M-Mutated Lung Cancer
Scientists assessed whether the combination of suberoylanilide hydroxamic acid, a potent HDAC inhibitor, and BIBW2992 or WZ4002 could overcome epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) resistance associated with T790M mutation in lung cancer cells. [Int J Cancer] Abstract

Cisplatin Sensitivity Is Enhanced in Non-Small Cell Lung Cancer Cells by Regulating Epithelial-Mesenchymal Transition through Inhibition of Eukaryotic Translation Initiation Factor 5A2
Researchers found low concentrations of GC7 have little effect on non-small cell lung cancer (NSCLC) viability, but could enhance cisplatin cytotoxicity in NSCLC cells. GC7 also could reverse mesenchymal phenotype in NCI-H1299 and prevented A549 cells undergoing epithelial-mesenchymal transition after TGF-β1 inducement. [BMC Pulm Med] Full Article

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Regeneron and Sanofi Announce Positive Results from Phase IIb Study of Dupilumab in Patients with Moderate-to-Severe Asthma
Regeneron Pharmaceuticals, Inc. and Sanofi announced positive results from the interim analysis of a dose-ranging Phase IIb study of dupilumab in adult patients with uncontrolled moderate-to-severe asthma. [Regeneron Pharmaceuticals, Inc.] Press Release

Clovis Oncology Announces First Patient Enrolled in TIGER-1 Study
Clovis Oncology, Inc. announced that the Phase II portion of the seamless Phase II/III TIGER-1 (Third-Generation Inhibitor of Mutant EGFR in Lung Cancer) study has commenced with the dosing of the first patient at a U.S. study site. [Clovis Oncology, Inc.] Press Release

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Therapeutic Goods Administration (Australia)

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NEW Research Scientist – Cancer and Inflammatory Diseases (Qu Biologics Inc.)

Postdoc/Staff Scientist – Lung Fibroblast Biology (Cincinnati Children’s Hospital Medical Center)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Postdoctoral Research Fellow – Lung Pathophysiology (Brigham & Women’s Hospital – Harvard Medical School)

PhD Positions – Cardiovascular-Pulmonary Science (Chonbuk National University)

Postdoctoral Researcher – Metabolomics of Pulmonary Medicine (Karolinska Institute)

Investigator – Multiple Positions in Cellular & Molecular Medicine (Cleveland Clinic Lerner Research Institute)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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