Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol Scientists observed a significant induction of oxidative stress induced by S. pneumoniae in vivo, ex vivo, and in vitro. Upon stimulation, the oxidant responsive transcription factor Nrf2 was activated, and catalase was upregulated via Nrf2. [J Infect Dis] Abstract Lymphotoxin β Receptor Signaling Induces IL-8 Production in Human Bronchial Epithelial Cells Scientists aimed to elucidate the molecular mechanism of LIGHT-induced cytokine/chemokine production by bronchial epithelial cells. [PLoS One] Full Article Arsenite-Induced Pseudo-Hypoxia Results in Loss of Anchorage-Dependent Growth in BEAS-2B Pulmonary Epithelial Cells Researchers modeled arsenic-exposed human pulmonary epithelial cells in vitro with BEAS-2B, a non-malignant lung epithelial cell line. Constant exposure to 1 µM arsenite resulted in the early loss of anchorage-dependent growth, measured by soft agar colony formation, beginning at six weeks of exposure. [PLoS One] Full Article Role of Reactive Oxygen Species in Arsenic-Induced Transformation of Human Lung Bronchial Epithelial (BEAS-2B) Cells Scientists used expressions of catalase and superoxide dismutase 2 to decrease reactive oxygen species (ROS) level and investigated their role in the process of arsenic-induced cell transformation. They show that inhibition of ROS by antioxidant enzymes decreased arsenic-induced cell transformation, demonstrating that ROS are important in this process. [Biochem Biophys Res Commun] Abstract Retinoic Acid Promotes Primary Fetal Alveolar Epithelial Type II Cell Proliferation and Differentiation to Alveolar Epithelial Type I Cells Researchers observed the effect of retinoic acid on the proliferation and differentiation of primary fetal alveolar epithelial type II cells. [In Vitro Cell Dev Biol Anim] Abstract LUNG CANCER Long Noncoding RNA ANRIL Promotes Non Small Cell Lung Cancer Cells Proliferation and Inhibits Apoptosis by Silencing KLF2 and P21 Expression Researchers reported that ANRIL expression was increased in non small cell lung cancer tissues and its expression level was significantly correlated with TNM stages and tumor size. [Mol Cancer Ther] Abstract Enhanced Cytotoxic Activity of Cetuximab in EGFR-Positive Lung Cancer by Conjugating with Gold Nanoparticles Scientists report that conjugation of cetuximab (C225) with gold nanoparticles enhances the cytotoxicity of C225 in non-small cell lung cancer both in vitro and in vivo. [Sci Rep] Full Article Biological and Clinical Significance of Epigenetic Silencing of MARVELD1 Gene in Lung Cancer Researchers found the reduced MARVELD1 expression significantly correlated with diagnostic histopathology and malignant degree of lung cancers. DNA hypermethylation and histone deacetylation synergistically inactivated MARVELD1 gene in lung cancer cells. [Sci Rep] Full Article |