Increased IL-33 Expression in Chronic Obstructive Pulmonary Disease Researchers investigated the expression of interleukin-33 (IL-33) in chronic obstructive pulmonary disease (COPD) and to aimed determine whether IL-33 participates in the initiation and progression of COPD. [Am J Physiol Lung Cell Mol Physiol] Abstract Temporal-Spatial Variations of the Physicochemical Characteristics of Air Pollution Particulate Matter (PM2.5-0.3) and Toxicological Effects in Human Bronchial Epithelial Cells (BEAS-2B) Researchers studied some physicochemical characteristics and toxicological endpoints of PM2.5-0.3 samples produced during two different seasons in three different surroundings were studied, thereby expecting to differentiate their respective adverse effects in BEAS-2B cells. [Environ Res] Abstract Role of p53-Fibrinolytic System Cross-Talk in the Regulation of Quartz-Induced Lung Injury Scientists explored whether p53-mediated changes in the urokinase-type plasminogen activator (uPA) system contributes to silica-induced lung injury. Treatment of wild-type mice with caveolin-1 scaffolding domain peptide inhibits PAI-1, restores uPA expression and prevents alveolar epithelial cell apoptosis by suppressing p53, which is otherwise induced in mice exposed to silica. [Toxicol Appl Pharmacol] Abstract Conditional Overexpression of TGFβ1 Promotes Pulmonary Inflammation, Apoptosis and Mortality via TGFβR2 in the Developing Mouse Lung Researchers revealed that increased transforming growth factor beta 1 (TGFβ1) expression in newborn mice lungs leads to increased mortality, macrophage and immature monocyte infiltration, apoptotic cell death specifically in type II alveolar epithelial cells, impaired alveolarization, and dysregulated angiogenic molecular markers. [Respir Res] Abstract | Full Article Desialylation of Airway Epithelial Cells during Influenza Virus Infection Enhances Pneumococcal Adhesion via Galectin Binding Researchers examined the possibility that galectins expressed in the airway epithelial cells might play a significant role in viral or pneumococcal adhesion to airway epithelial cells. [Mol Immunol] Abstract LUNG CANCER Targeting LunX Inhibits Non-Small-Cell Lung Cancer Growth and Metastasis Researchers report the identification of a novel candidate therapeutic target, LunX, as a molecule overexpressed in primary non-small-cell lung cancer and lymph node metastases that is associated with reduced postoperative survival. Functional studies demonstrated that LunX overexpression promoted lung cancer cell migration and proliferation by interactions with the chaperone protein 14-3-3. [Cancer Res] Abstract Role of Nicotinic Acetylcholine Receptors in Cell Proliferation and Tumor Invasion in Broncho-Pulmonary Carcinomas Scientists examined the localization of nicotinic acetylcholine receptors (nAChRs) in human lung tumors and, by using primary cultures of tumor cells derived from these tumors, determining the nAChR roles in cell proliferation and tumor invasion. [Lung Cancer] Abstract β-Elemene Inhibited Expression of DNA Methyltransferase 1 through Activation of ERK1/2 and AMPKα Signaling Pathways in Human Lung Cancer Cells: The Role of Sp1 Researchers show that β-elemene inhibits human non-small cell lung carcinoma cell growth, and increased phosphorylation of ERK1/2, Akt and AMPKα. [J Cell Mol Med] Abstract Hsp90 Inhibitor NVP-AUY922 Enhances the Radiation Sensitivity of Lung Cancer Cell Lines with Acquired Resistance to EGFR-Tyrosine Kinase Inhibitors Scientists evaluated the radiosensitizing effect of the novel Hsp90 inhibitor, NVP-AUY922, on non-small cell lung cancer cell lines harboring epidermal growth factor receptor (EGFR) activating mutations and showing acquired resistance to EGFR-tyrosine kinase inhibitors via any of several mechanisms. [Oncol Rep] Abstract |