Pulmonary Cell News Volume 4.03 | Jan 29 2015

Maternal Vitamin D and E Intakes during Early Pregnancy Are Associated with Airway Epithelial Cell Responses in Neonates
Researchers tested the hypothesis that maternal vitamin D and E status in early pregnancy is associated with airway epithelial cell (AEC) responses in new born infants and examined constitutive and TNFα/IL-1β, house dust mite extract or lipopolysaccharide stimulated neonatal AEC responses in vitro. [Clin Exp Allergy] Abstract

Cytotoxicity, Oxidative Stress and Genotoxicity Induced by Glass Fibers on Human Alveolar Epithelial Cell Line A549
Scientists aimed to verify the cytotoxic and genotoxic effects and oxidative stress production induced by in vitro exposure of human alveolar epithelial cells A549 to glass fibers. [Toxicol In Vitro] Abstract

A Pharmacometric Pulmonary Model Predicting the Extent and Rate of Distribution from Plasma to Epithelial Lining Fluid and Alveolar Cells – Using Rifampicin as an Example
Researchers developed a drug-unspecific approach to pharmacometric modeling for predicting the rate and extent of distribution from plasma to epithelial lining fluid and alveolar cells for data emanating from studies involving bronchoalveolar lavage sampling, using rifampicin as an example. [Eur J Clin Pharmacol] Full Article

LUNG CANCER

β-Arrestin-1 Mediates Nicotine-Induced Metastasis through E2F1 Target Genes that Modulate Epithelial-Mesenchymal Transition
Stimulation of multiple non-small cell lung cancer (NSCLC) cell lines with nicotine led to enhanced recruitment of β-arrestin-1 and E2F1 on vimentin, fibronectin, ZEB1 and ZEB2 promoters. Further, there was significantly more β-arrestin-1 and E2F1 associated with these promoters in human NSCLC tumors and β-arrestin-1 levels correlated with vimentin and fibronectin levels in human NSCLC samples. [Cancer Res]
Abstract | Press Release

Phosphorylation of FADD by the Kinase CK1α Promotes KRAS^G12D-Induced Lung Cancer
Using immunohistochemistry analysis and in vivo imaging of conditional mouse models of KRAS^G12D-driven lung cancer, scientists found that the deletion of the gene encoding Fas-associated death domain (FADD) suppressed tumor growth, reduced the proliferative index of cells, and decreased the activation of downstream effectors of the RAS-MAPK pathway that promote the cell cycle, including retinoblastoma and cyclin D1. [Sci Signal] Abstract

Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer
Researchers show that the receptor tyrosine kinase EphA5 is specifically overexpressed in lung cancer, and is involved in regulating cellular responses to genotoxic insult. In the absence of EphA5, lung cancer cells displayed a defective G1/S cell cycle checkpoint, were unable to resolve DNA damage, and became radiosensitive. [J Biol Chem] Abstract | Full Article

WT1 Enhances Proliferation and Impedes Apoptosis in KRAS Mutant NSCLC via Targeting cMyc
Scientists investigated the role of WT1 and KRAS in proliferation and apoptosis. The potential mechanisms that WT1 promotes proliferation and impedes apoptosis through affecting multiple apoptosis-related regulators in KRAS mutant non-small cell lung cancer (NSCLC) cells were identified. [Cell Physiol Biochem] Abstract

Epigenetic Inactivation of SOX1 Promotes Cell Migration in Lung Cancer
Researchers investigated whether the promoter hypermethylation of SOX1 is involved in human lung carcinogenesis. They demonstrate that restoration of SOX1 inhibited cell migration by regulating actin cytoskeletal remodeling. [Tumor Biol] Abstract

Significantly Inhibitory Effects of Low Molecular Weight Heparin (Fraxiparine) on the Motility of Lung Cancer Cells and Its Related Mechanism
Scientists found that Fraxiparine significantly inhibited the invasive, migratory, and adhesive characteristics of A549 and 95D cells after 24 hours incubation in a dose-dependent manner. [Tumor Biol] Abstract

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Trudeau Institute Researcher Receives NIH Funding
The Trudeau Institute has been awarded $536,000 over a two-year period from the National Institute of Allergy and Infectious Diseases. The grant will support a research project of Alexei Tumanov, M.D., Ph.D., “Defining the role of lymphotoxin signaling in viral-induced lung immunopathology.” [Trudeau Institute] Press Release

New Animal Models Faithfully Reproduce the Tumor of Each Patient
A team from the Catalan Institute of Oncology and Bellvitge Biomedical Research Institute has developed new animal models that reproduce faithfully the evolution and malignancy of different human tumors. [Bellvitge Biomedical Research Institute] Press Release

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Director (California Institute for Regenerative Medicine)

Postdoctoral Fellow – Lung Cancer (MD Anderson Cancer Center)

Postdoctoral Fellow – Cystic Fibrosis Research (University of Tennessee Health Science Center)

Postdoctoral Research Fellow – Post-Transcriptional Gene Regulation Governing Cancer Cell Behavior (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Wnt Signaling in Development and Disease (Van Andel Research Institute)

Staff Scientist – Lung Cancer (University of Pennsylvania)

Postdoctoral Fellow – Cytokine-Induced Lung Inflammation (Cleveland Clinic Lerner Research Institute)

Postdoctoral Positions – Lung and Dermal Uptake Modeling (Karolinska Institutet)

Postdoctoral Position – Lung Cancer, Lung Regeneration and Lung Development (University of California – San Francisco)

PhD Students – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

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