Pulmonary Cell News Volume 4.08 | Mar 5 2015

Silencing Angiopoietin-Like Protein 4 (ANGPTL4) Protects against Lipopolysaccharide-Induced Acute Lung Injury via Regulating SIRT1 /NF-kB Pathway
Scientists reported that angptl4 levels were increased both in human alveolar epithelial A549 cells and lung tissues obtained from a mouse model of lipopolysaccharide (LPS)-induced acute lung injury. Angptl4 expression was induced by LPS in alveolar epithelial cells, whereas LPS-induced lung inflammation, lung permeability, tissue damage and mortality rates were attenuated in AngsiRNA-treated mice. [J Cell Physiol] Abstract

Phenotypic Responses of Differentiated Asthmatic Human Airway Epithelial Cultures to Rhinovirus
Scientists evaluated an in vitro air liquid interface cultured human airway epithelial cell model for human rhinovirus (HRV) infection, and identified gene expression patterns associated with asthma intrinsically and/or after HRV infection using this model. [PLoS One] Full Article

The Effect of Fe₂O₃ and ZnO Nanoparticles on Cytotoxicity and Glucose Metabolism in Lung Epithelial Cells
Researchers demonstrate that ZnO nanoparticles, but not Fe₂O₃ nanoparticles, induce cell cycle arrest, cell apoptosis, reactive oxygen species production, mitochondrial dysfunction and glucose metabolism perturbation, which are responsible for cytotoxicity. [J Appl Toxicol] Abstract

RNA-Binding Motif Protein 5 Negatively Regulates the Activity of Wnt/β-Catenin Signaling in Cigarette Smoke-Induced Alveolar Epithelial Injury
Scientists determined the involvement of RNA-binding motif protein 5 and Wnt/β-catenin signaling in cigarette smoke-induced alveolar epithelial injury, as well as the interaction between both. They revealed that cigarette smoke extract inhibited A549 cell viability in both a dose- and time-dependent manner. [Oncol Rep] Abstract

LUNG CANCER

Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to Ex Vivo Human and Mouse Lung Tumors
Scientists provide proof-of-concept evidence for successful matrix metalloproteinase 9-triggered drug release from mesoporous silica nanoparticles in human tumor cells and in mouse and human lung tumors using the novel technology of ex vivo 3D lung tissue cultures. [ACS Nano]
Abstract | Graphical Abstract | Press Release

Assessment of ABT-263 Activity across a Cancer Cell Line Collection Leads to a Potent Combination Therapy for Small-Cell Lung Cancer
Researchers examined the efficacy of ABT-263 across >500 cancer cell lines, including 311 for which they had matched expression data for select genes. They found that high expression of the proapoptotic gene Bcl2-interacting mediator of cell death predicts sensitivity to ABT-263. [Proc Natl Acad Sci USA] Abstract

PARVA Promotes Metastasis by Modulating ILK Signaling Pathway in Lung Adenocarcinoma
Using a lung cancer invasion cell line model and expression microarrays, researchers identified α-parvin (PARVA) as a potential oncogene. The overexpression of PARVA increased cell invasion, colony-forming ability and endothelial cell tube formation. By contrast, knockdown of PARVA inhibited invasion and tube formation in vitro. [PLoS One] Full Article

C6orf106 Enhances NSCLC Cell Invasion by Upregulating Vimentin, and Downregulating E-Cadherin and P120ctn
The relationships between subcellular localization and clinical pathological factors were analyzed. Through chromosome 6 open reading frame 106 (C6orf106) overexpression and repression, respectively, in lung cancer cell lines, investigators explored the effect of this molecule on non-small cell lung cancer (NSCLC) invasion abilities. [Tumor Biol] Abstract

Pemetrexed Induces Apoptosis in Malignant Mesothelioma and Lung Cancer Cells through Activation of Reactive Oxygen Species and Inhibition of Sirtuin 1
Scientists investigated the involvement of reactive oxygen species and sirtuin 1 in pemetrexed-induced apoptosis in MSTO-211 malignant mesothelioma cells and A549 non-small cell lung cancer cells. [Oncol Rep] Abstract

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FDA Approves Opdivo (Nivolumab) for the Treatment of Patients with Previously Treated Metastatic Squamous Non-Small Cell Lung Cancer
Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration (FDA) has approved Opdivo injection, for intravenous use, for the treatment of patients with metastatic squamous non-small cell lung cancer with progression on or after platinum-based chemotherapy. [Bristol-Myers Squibb Company]
Press Release

ABRAXANE^® Approved by European Commission for First-Line Treatment of Patients with Non-Small Cell Lung Cancer
Celgene International Sàrl announced that the European Commission has approved ABRAXANE^® in combination with carboplatin for the first-line treatment of non-small cell lung cancer in adult patients who are not candidates for potentially curative surgery and/or radiation therapy. [Celgene International Sàrl]
Press Release

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