Linking Progression of Fibrotic Lung Remodeling and Ultrastructural Alterations of Alveolar Epithelial Type II Cells in the Amiodarone Mouse Model Scientists hypothesized that ultrastructural alterations of the intracellular surfactant pool are signs of epithelial stress correlating with the severity of fibrotic remodeling. Mean volume of alveolar epithelial type II cells (AE2) cells, volume of lamellar bodies per AE2 cell and mean size of lamellar bodies were correlated to structural parameters reflecting severity of fibrosis like collagen content. [Am J Physiol Lung Cell Mol Physiol] Abstract In Vitro Suppression of IL-6 and IL-8 Release from Human Pulmonary Epithelial Cells by Non-Anticoagulant Fraction of Enoxaparin Scientists identified the fraction responsible for the observed anti-inflammatory effect of enoxaparin and to determine the relationship between its structure and biological activities. A549 pulmonary epithelial cells were pre-treated in the presence of enoxaparin and its fractions. [PLoS One] Full Article Overexpression of Telomerase Protects Human and Murine Lung Epithelial Cells from Fas- and Bleomycin-Induced Apoptosis via FLIP Upregulation Researchers hypothesized that telomerase overexpression affects Fas-induced epithelial cell apoptosis by an extra-telomeric role such as regulation of anti-apoptotic genes, specifically FLICE-like inhibitory protein (FLIP). Telomerase in mouse and human lung epithelial cell lines was upregulated by transient transfection using cDNA hTERT expression vector. [PLoS One] Full Article Ciliatoxicity in Human Primary Bronchiolar Epithelial Cells after Repeated Exposure at the Air-Liquid Interface with Native Mainstream Smoke of K3R4F Cigarettes with and without Charcoal Filter Investigators present an in vitro model of primary normal human bronchiolar epithelial cells with in vivo like morphology to study the influence of cigarette mainstream smoke on ciliated cells. [Exp Toxicol Pathol] Abstract LUNG CANCER Repression of TIF1γ by SOX2 Promotes TGF-β-Induced Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer Researchers investigated the mechanistic role of transcriptional intermediary factor 1 γ (TIF1γ) in transforming growth factor (TGF)-β-induced epithelial-mesenchymal transition, as well as a link between TIF1γ and SOX2 in non-small-cell lung cancer. [Oncogene] Abstract Anti-HER3 Monoclonal Antibody Patritumab Sensitizes Refractory Non-Small Cell Lung Cancer to the Epidermal Growth Factor Receptor Inhibitor Erlotinib Heregulin overexpression induced epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC) cells harboring an activating EGFR mutation, while human epidermal growth factor receptor 3 (HER3) and AKT activation was maintained in the presence of erlotinib in heregulin-overexpressing, EGFR-mutant NSCLC cells. [Oncogene] Abstract Enhanced Expression of Cohesin Loading Factor NIPBL Confers Poor Prognosis and Chemotherapy Resistance in Non-Small Cell Lung Cancer The authors measured the expression of NIPBL in clinical non-small cell lung cancer specimens, and determined its effects on cellular processes and chemosensitivity in vitro. [J Transl Med] Abstract | Full Article Low miR-145 Silenced by DNA Methylation Promotes NSCLC Cell Proliferation, Migration and Invasion by Targeting Mucin 1 Researchers report that miR-145 expression is decreased in non-small cell lung cancer (NSCLC) cell lines and tumor tissues and that this low level of expression is associated with DNA methylation. [Cancer Biol Ther] Abstract Activation of M3 Muscarinic Receptor by Acetylcholine Promotes Non-Small Cell Lung Cancer Cell Proliferation and Invasion via EGFR/PI3K/AKT Pathway Investigators found that acetylcholine dose-dependently promoted the proliferation, invasion, and migration of non-small cell lung cancer cells. [Tumour Biol] Abstract Ski Prevents TGF-β-Induced EMT and Cell Invasion by Repressing SMAD-Dependent Signaling in Non-Small Cell Lung Cancer The authors investigated the mechanistic role of Ski in non-small cell lung cancer (NSCLC) metastasis. Ski was significantly reduced in metastatic NSCLC cells or tissues when compared with non-metastatic NSCLC cells or tissues. [Oncol Rep] Abstract |