Contribution of Alveolar Type II Cell–Derived Cyclooxygenase-2 to Basal Airway Function, Lung Inflammation, and Lung Fibrosis Researchers generated mice with alveolar type II (ATII) cell–specific knockdown of COX-2, to examine the role of ATII cell–derived prostaglandins in these processes. [FASEB J] Abstract Differential Susceptibility of Human Lung Primary Cells to H1N1 Influenza Viruses Investigators report that alveolar epithelial cells (AECs) are the direct targets for H1N1 viruses that have circulated since the 2009 pandemic (H1N1pdm09). Alveolar macrophages are less susceptible to H1N1pdm09 virus, but they produce significantly more inflammatory cytokines than AECs from the same donor. [J Virol] Abstract Basal Cells of the Human Airways Acquire Mesenchymal Traits in Idiopathic Pulmonary Fibrosis and in Culture To determine if p63-positive basal cells were able to undergo epithelial-to-mesenchymal transition in culture, scientists treated VA10, a p63-positive basal cell line, with the serum replacement UltroserG. A sub-population of treated cells acquired a mesenchymal phenotype, including an E- to N-cadherin switch. [Lab Invest] Abstract Amelioration of Particulate Matter-Induced Oxidative Damage by Vitamin C and Quercetin in Human Bronchial Epithelial Cells The authors indicated that fine particulate matter depleted the cell viability of 16HBE cells, elevated reactive oxygen species generation, and inhibited mitochondrial genes expressions, including fusion proteins Mfn1 and OPA1, along with biogenesis markers SIRT1 and p53R2. [Chemosphere] Abstract Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells In order to investigate the mechanisms of air pollution-induced lung toxicity in humans, human bronchial epithelial cells were exposed to various concentrations of particles smaller than 2.5 μm (PM2.5) collected from Beijing, China. [PLoS One] Full Article LUNG CANCER Down-Regulation of MicroRNA-144 in Air Pollution-Related Lung Cancer MicroRNA (miR)-144 interacted with the oncogene Zeb1 at 2 sites in its 3′ untranslated region, and a decrease in miR-144 resulted in increased Zeb1 expression and an epithelial mesenchymal transition phenotype. Ectopic expression of miR-144 suppressed non-small cell lung cancers in vitro and in vivo by targeting Zeb1. [Sci Rep] Full Article BMP4 Depletion by miR-200 Inhibits Tumorigenesis and Metastasis of Lung Adenocarcinoma Cells The authors investigated the mechanism and role of bone morphogenetic protein 4 (BMP4) depletion by microRNA-200 (miR-200) in murine lung adenocarcinoma cells. [Mol Cancer] Full Article HEPACAM Inhibited the Growth and Migration of Cancer Cells in the Progression of Non-Small Cell Lung Cancer Scientists found that the expression of hepatocyte cell adhesion molecule (HEPACAM) was downregulated in non-small cell lung cancer (NSCLC) tissues. Forced expression of HEPACAM in NSCLC cells inhibited the growth and migration of the cancer cells, while knocking down the expression of HEPACAM promoted cell growth, migration, and metastasis. [Tumor Biol] Abstract |