Pulmonary Cell News Volume 4.48 | Dec 10 2015

Integrative Transcriptomic and Protein Analysis of Human Bronchial BEAS-2B Exposed to Seasonal Urban Particulate Matter
Human bronchial epithelial cells were used to analyze the pathways activated after exposure to summer and winter urban particulate matter and to identify possible markers of exposure. [Environ Pollut] Abstract

Angiotensin 1-7/Mas Inhibits Apoptosis in Alveolar Epithelial Cells through Upregulation of Map Kinase Phosphatase-2
It was theorized that angiotensin 1-7 activates a map kinase phosphatase and thereby reduces JNK phosphorylation to inhibit apoptosis and promote cell survival. This hypothesis was evaluated in the human A549 and mouse MLE12 alveolar epithelial cell (AEC) lines and primary cultures of human AECs. [Am J Physiol Lung Cell Mol Physiol] Abstract

Aspirin Inhibits LPS-Induced Expression of PI3K/Akt, ERK, NF-κB, CX3CL1, and MMPs in Human Bronchial Epithelial Cells
The authors focused on the effects of aspirin on lipopolysaccharide (LPS)-induced expression of phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt), extracellular signal-regulated protein kinase (ERK), nuclear factor-κB (NF-κB), CX3CL1, and MMPs in human bronchial epithelial cells. [Inflammation] Abstract

Induction of the Matrix Metalloproteinase 13 Gene in Bronchial Epithelial Cells by Interferon and Identification of its Novel Functional Polymorphism
Researchers investigated the mechanisms and roles of matrix metalloproteinase 13 (MMP-13) secretion in human small airway epithelial cells and functional polymorphisms of the MMP13 gene. [Inflammation] Abstract

LUNG CANCER

Resveratrol Overcomes Gefitinib Resistance by Increasing the Intracellular Gefitinib Concentration and Triggering Apoptosis, Autophagy and Senescence in PC9/G NSCLC Cells
Investigators demonstrated that resveratrol could synergize with gefitinib (Gef) to inhibit the proliferation of Gef-resistant non-small cell lung cancer (NSCLC) cells. [Sci Rep] Full Article

miR-512-5p Induces Apoptosis and Inhibits Glycolysis by Targeting p21 in Non-Small Cell Lung Cancer Cells
Overexpression of miR-512-5p induced apoptosis of non-small cell lung cancer (NSCLC) cell lines A549 and H1299, and miR-512-5p inhibitor reversed this effect in H1299 cells stably expressing miR-512. miR-512-5p inhibited glycolysis and migration in NSCLC cells, but shows no effect on cell proliferation. [Int J Oncol] Abstract

Targeting of Carbon Ion-Induced G2 Checkpoint Activation in Lung Cancer Cells Using Wee-1 Inhibitor MK-1775
The authors investigated the effects of carbon ions in combination with MK-1775 on the killing of non-small cell lung cancer cells. [Radiat Res] Abstract

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Cuban Cancer Vaccine Extended to Policlinics
The Cuban CIMAVAX EGF therapeutic vaccine produced in the Molecular Engineering Center has begun new clinical testing against lung cancer in policlinics throughout the country. [Molecular Engineering Center (Cuban News Agency)] Press Release

Pfizer Announces U.S. FDA Acceptance and Priority Review of Supplemental New Drug Application for XALKORI® for the Treatment of Patients with ROS1-Positive Metastatic Non-Small Cell Lung Cancer
Pfizer Inc. announced that the U.S. Food and Drug Administration (FDA) has accepted and granted Priority Review for a supplemental New Drug Application for XALKORI® for the treatment of patients with metastatic non-small cell lung cancer whose tumors are ROS1-positive. [Pfizer Inc.] Press Release

Biothera Announces Clinical Study to Evaluate Combination Therapy of Imprime PGG and Merck’s Checkpoint Inhibitor Keytruda in Patients with Non-Small Cell Lung Cancer
Biothera Pharmaceutical Inc. announced plans for a Phase Ib/II clinical study in non-small lung cancer patients to evaluate the ability of Biothera’s Imprime PGG to enhance responses to pembrolizumab, the anti-PD-1 antibody from Merck. [Biothera Pharmaceutical Inc.] Press Release

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Postdoctoral Positions – Lung Cancer Research (University of Texas)

Postdoctoral Scientist (Bioinformatician) – Clinical and Experimental Pharmacology (Cancer Research UK Manchester Institute)

PhD Studentships – Cancer and Allergy (University of Salzburg)

Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Postdoctoral Fellow – Cancer Biology (Cold Spring Harbor Laboratory)

Postdoctoral Positions – Fibrotic Remodeling of the Lung (University of Vermont)

Postdoctoral Positions – Cancer (University of Texas MD Anderson Cancer Center)

Post-Doctoral Fellow – Lung Microbiome Research and Asthma (University of Michigan)

Postdoctoral Fellowship – Developmental Cell Biology and Regenerative Medicine (University of California San Francisco)

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