High Mobility Group Box 1-Induced Epithelial Mesenchymal Transition in Human Airway Epithelial Cells Researchers used RNA sequencing to show that high mobility group box 1 treatment regulated epithelial–mesenchymal transition-related gene expression in human primary-airway epithelial cells. [Sci Rep] Full Article Bixin Protects Mice against Ventilation-Induced Lung Injury in an NRF2-Dependent Manner In vitro, bixin was found to activate the NRF2 signaling pathway through blockage of ubiquitylation and degradation of NRF2 in a KEAP1-C151 dependent manner; intraperitoneal injection of bixin led to pulmonary upregulation of the NRF2 response in vivo. [Sci Rep] Full Article Mesenchymal Stem Cells Protect from Hypoxia-Induced Alveolar Epithelial-Mesenchymal Transition The authors investigated whether human mesenchymal stem cells would prevent epithelial-mesenchymal transition induced by hypoxia in primary rat alveolar epithelial cells. [Am J Physiol Lung Cell Mol Physiol] Abstract Aeroallergen Der p 2 Induces Apoptosis of Bronchial Epithelial BEAS-2B Cells via Activation of Both Intrinsic and Extrinsic Pathway Investigators showed that recombinant Der p 2 inhibited cell growth and induced apoptosis of human bronchial epithelial cell BEAS-2B. [Cell Biosc] Full Article KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells Researchers assessed whether primary human bronchial epithelial cells (HBECs) express the KCa3.1 channel and its role in HBEC function. Primary HBECs from the airways of healthy and asthmatic subjects, SV-transformed BEAS-2B cells and the neoplastic H292 epithelial cell line were studied. [PLoS One] Full Article Brominated Flame Retardants, Hexabromocyclododecane and Tetrabromobisphenol A, Affect Proinflammatory Protein Expression in Human Bronchial Epithelial Cells via Disruption of Intracellular Signaling Hexabromocyclododecane exposure significantly increased the expression of intercellular adhesion molecule-1 and the production of interleukin-6 and -8 in human bronchial epithelial cells. [Toxicol In Vitro] Abstract LUNG CANCER Synergistic Killing of Human Small Cell Lung Cancer Cells by the Bcl-2-Inositol 1,4,5-Trisphosphate Receptor Disruptor BIRD-2 and the BH3-Mimetic ABT-263 Scientists report for the first time that Bcl-2-IP3 receptor disruptor-2 (BIRD-2), a decoy peptide that binds to the BH4 domain of Bcl-2 and prevents Bcl-2 interaction with inositol 1,4,5-trisphosphate receptors, induces cell death in a wide range of small cell lung cancer lines, including ABT-263-resistant lines. [Cell Death Dis] Full Article Expression of MicroRNA-452 via Adenoviral Vector Inhibits Non-Small Cell Lung Cancer Cells Proliferation and Metastasis The authors identified how miR-452 acts in regulating non-small cell lung cancer (NSCLC) proliferation and metastasis. Expression of miR-452 via adenoviral vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460. [Tumor Biol] Abstract The Attenuation of Epithelial to Mesenchymal Transition and Induction of Anoikis by Gigantol in Human Lung Cancer H460 Cells Investigators demonstrated for the first time that gigantol significantly decreases lung cancer cells’ viability in a detached condition through anoikis and anchorage-independent assays. [Tumor Biol] Abstract |