Pulmonary Cell News Volume 5.03 | Jan 28 2016

Electrolyte Transport Properties in Distal Small Airways from Cystic Fibrosis Pigs with Implications for Host Defense
The authors adapted a novel protocol to isolate small airway epithelial cells from cystic fibrosis (CF) and non-CF pigs and established an organotypic culture model. Compared to non-CF large airways, non-CF small airway epithelia cultures had higher Cl^– and bicarbonate short-circuit currents and higher airway surface liquid pH under 5 percent CO₂ conditions. [Am J Physiol Lung Cell Mol Physiol] Abstract

Interferon Regulatory Factor 7 Regulates Airway Epithelial Cell Responses to Human Rhinovirus Infection
At present, the molecular mechanisms that underpin human rhinoviruses responses in airway epithelial cells are incompletely understood. Scientists employed microarray profiling, upstream regulator analysis, and siRNA mediated gene silencing to further the understanding of the role of interferon regulatory factor 7 in this response. [BMC Genomics] Full Article

Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in COPD Epithelium
Researchers showed that primary bronchial epithelial cells from subjects with chronic obstructive pulmonary disease (COPD) have impaired induction of type I interferon (IFN) and lead to heightened viral replication following influenza viral infection. [Am J Respir Cell Mol Biol] Abstract

LUNG CANCER

Ninjurin1 Suppresses Metastatic Property of Lung Cancer Cells through Inhibition of Interleukin-6 Signaling Pathway
Researchers showed that inhibition of nerve injury-induced protein 1 (Ninjurin1, Ninj1) promotes lung cancer metastasis through IL-6/STAT3 signaling. Ninj1 levels were relatively low in highly motile lung cancer cells. While inhibition of Ninj1 enhanced cell migration in lung cancer cells, overexpression of Ninj1 significantly suppressed it. [Int J Cancer] Abstract

Interleukin-33 Enhances Programmed Oncosis of ST2L-Positive Low-Metastatic Cells in the Tumor Microenvironment of Lung Cancer
Researchers showed that ST2 was significantly downregulated in human lung cancer tissues and cells compared with normal lung tissues and cells. Interleukin-33 expression was also inversely correlated with the stages of human lung cancers. [Cell Death Dis] Full Article

ADAM23 Is Down-Regulated in Side Population and Suppresses Lung Metastasis of Lung Carcinoma Cells
To examine the members of the ADAM, ADAMTS and MMP gene families related to phenotypes of side population (SP) and main population (MP), the authors screened the expression of all the members in the propagated SP and MP of A549 lung adenocarcinoma cells, and found that the relative expression ratio of ADAM23 in MP to SP is most highly increased, but none of them is increased in SP. [Cancer Sci] Abstract

Aspirin Inhibits Epithelial-to-Mesenchymal Transition and Migration of Oncogenic K-Ras-Expressing Non-Small Cell Lung Carcinoma Cells by Down-Regulating E-Cadherin Repressor Slug
Researchers aimed to discern the molecular mechanisms that regulate Slug/E-cadherin axis in oncogenic K-ras-expressing non-small cell lung carcinoma cells, and the effect of aspirin in modulating the same. [BMC Cancer] Full Article

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Health Canada Approves ^PrORKAMBI^® (Lumacaftor/Ivacaftor) – The First Medicine to Treat the Underlying Cause of Cystic Fibrosis for People Ages 12 and Older with Two Copies of the F508del Mutation
Vertex Pharmaceuticals Incorporated announced that Health Canada has approved ^PrORKAMBI^®, the first medicine to treat the underlying cause of cystic fibrosis in people ages 12 and older with two copies of the F508del mutation. [Vertex Pharmaceuticals Incorporated] Press Release

Lipman Gift Aims at Development of Breakthrough Treatments for Cystic Fibrosis through Sorscher Recruitment
A new philanthropic gift to Emory University will support the advancement of cystic fibrosis research with the aim of developing effective new drug therapies and a cure for the disease. The gift from Eva and Charles Lipman will contribute substantially to the laboratory of Eric J. Sorscher, MD. [Emory University] Press Release

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Project Scientist – Pulmonary Fibrosis (Cedars Sinai Medical Center)

PhD and MD/PhD Positions – Translational Pulmonary Medicine (Helmholtz Association)

Postdoctoral Fellow – Bioinformatics RNA Biology & Cancer (German Cancer Research Center)

Postdoctoral Fellow/Research Associate – Cancer Therapy (Memorial Sloan Kettering Cancer Center)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

Postdoctoral Researcher – Immunology (Research Centre for Respiratory Diseases)

Postdoctoral Research Fellow – Epigenetics/Systems Biology (National Heart, Lung, and Blood Institute)

Professor – Precision Cancer Medicine (German Cancer Research Center)

PhD Positions – Heart and Lung Research (Max Planck Institute for Heart and Lung Research)

Postdoctoral Positions – Lung Cancer Research (University of Texas)

PhD Studentships – Cancer and Allergy (University of Salzburg)

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