Thrombin Stimulates Albumin Transcytosis in Lung Microvascular Endothelial Cells via Activation of Acid Sphingomyelinase Researchers tested the hypothesis that thrombin may stimulate transcellular albumin transport across lung microvascular endothelial cells in an acid-sphingomyelinase dependent manner. [Am J Physiol Lung Cell Mol Physiol] Abstract Increased Susceptibility of cftr-/- Mice to LPS-Induced Lung Remodeling Investigators characterized the lung pathology and the immune response of cftr-/- and cftr+/+ mice to chronic administration of Pseudomonas aeruginosa lipopolysaccharide. [Am J Physiol Lung Cell Mol Physiol] Abstract Sequestration of Vascular Endothelial Growth Factor (VEGF) Induces Late Restrictive Lung Disease Researchers aimed to determine whether inducible, mesenchyme-specific VEGF inhibition in the neonatal mouse lung results in long-term modulation of alveolar epithelial type II cells and whole lung function. [PLoS One] Full Article Protective Effects of Myrtol Standardized against Radiation-Induced Lung Injury Investigators evaluated the effects of Myrtol standardized on radiation-induced lung injury, and to investigate the underlying mechanism. A mouse model of radiation-induced lung injury was generated by using thoracic irradiation with a single dose of 16 Gy. [Cell Physiol Biochem] Full Article Human Bronchial Epithelial Cells Exposed In Vitro to Diesel Exhaust Particles Exhibit Alterations in Cell Rheology and Cytotoxicity Associated with Decrease in Antioxidant Defenses and Imbalance in Pro- and Anti-Apoptotic Gene Expression Scientists used human bronchial epithelium cells in culture and evaluated their exposure to diesel exhaust particles in order to determine changes to cell rheology (viscoelasticity) and gene expression of the enzymes involved in oxidative stress, apoptosis, and cytotoxicity. [Environ Sci Pollut Res Int] Abstract LUNG CANCER Histone Acetyltransferase Inhibitor CPTH6 Preferentially Targets Lung Cancer Stem-Like Cells Investigators evaluated the efficacy of the thiazole derivative 3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone (CPTH6), a novel pCAF and Gcn5 histone acetyltransferase inhibitor, as a small molecule that preferentially targets lung cancer stem-like cells derived from non-small cell lung cancer patients. [Oncotarget] Full Article Lovastatin Lactone Elicits Human Lung Cancer Cell Apoptosis via a COX-2/PPARγ-dependent Pathway In A549 and H358 lung carcinoma cells the lipophilic prodrug lovastatin lactone led to a concentration-dependent decrease of viability and induction of DNA fragmentation, whereas its 3-hydroxy-3-methylglutaryl coenzyme A-inhibitory, ring-open acid form was inactive in this respect. [Oncotarget] Abstract Colchicine Induces Autophagy and Senescence in Lung Cancer Cells at Clinically Admissible Concentration: Potential Use of Colchicine in Combination with Autophagy Inhibitor in Cancer Therapy Researchers investigated the possible mechanism by which the efficacy of colchicine against lung cancer cells at a less toxic dose could be enhanced. Colchicine at clinically admissible concentration of 2.5 nM had no cytotoxic effect and caused no G2/M arrest in A549 cells. [Tumor Biol] Abstract Marine Steroid Derived from Acropora formosa Enhances Mitochondrial-Mediated Apoptosis in Non-Small Cell Lung Cancer Cells The authors isolated 2-ethoxycarbonyl-2-β-hydroxy-A-nor-cholest-5-ene-4one (ECHC) from butanol extracts of scleractinian coral (Acropora formosa) and reported its potential antioxidant and antimicrobial activity as well as less toxicity against zebrafish (Danio rerio). They explored p53-mediated apoptosis pathway enhanced by ECHC in A549 human non-small cell lung cancer cell lines. [Tumor Biol] Abstract Activation of MEK1/2-ERK1/2 Signaling during NNK-Induced Lung Carcinogenesis in Female a/J Mice To study the association of extracellular signal-regulated kinase 1/2 (ERK1/2) activation with mutation of Kras encoding an upstream activator of ERK1/2 in lung premalignant lesions, scientists immunohistochemically examined expression of phosphorylated forms of ERK1/2 and MAP/ERK kinase 1/2 proteins and correlation between ERK activation and mutation of Kras encoding an upstream activator of ERK1/2, in a mouse lung carcinogenesis model. [Cancer Med] Full Article |