Decreased Laminin Expression by Human Lung Epithelial Cells and Fibroblasts Cultured in Acellular Lung Scaffolds from Aged Mice The effects of age on extracellular matrix (ECM) composition in both native and decellularized mouse lungs were assessed as was the effect of young versus old acellular ECM on human bronchial epithelial cells and lung fibroblasts. [PLoS One] Full Article Cigarette Smoke Enhances the Expression of Profibrotic Molecules in Alveolar Epithelial Cells Investigators explored the effect of cigarette smoke on the gene expression profile and signaling pathways in alveolar epithelial cells. [PLoS One] Full Article IL-27 Inhibits the TGF-β1-Induced Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells Scientists assessed the effects of IL-27 on TGF-β1-induced epithelial–mesenchymal transition in alveolar epithelial cells. IL-27 increased the expression of epithelial phenotypic markers, including E-cadherin and β-catenin, and inhibited mesenchymal phenotypic markers, including vimentin and a-SMA in A549 cells. [BMC Cell Biol] Full Article Propofol Protects Rats and Human Alveolar Epithelial Cells against Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting HMGB1 Expression Researchers investigated the effects of propofol on the expression of high-mobility group box 1 (HMGB1) in a rat model of lipopolysaccharide-induced acute lung injury. [Inflammation] Abstract LUNG CANCER Temozolomide-Perillyl Alcohol Conjugate Induced Reactive Oxygen Species Accumulation Contributes to Its Cytotoxicity against Non-Small Cell Lung Cancer Researchers demonstrated how temozolomide-perillyl alcohol conjugate also exhibited its cytotoxicity against non-small cell lung cancer, the most common type of lung cancer, as evidence from cell/tumor proliferation inhibition, G2/M arrest, DNA damage and mitochondrial apoptosis. [Sci Rep] Full Article JMJD1A Promotes Tumorigenesis and Forms a Feedback Loop with EZH2/let-7c in NSCLC Cells Jumonji domain containing 1A (JMJD1A) was frequently upregulated in non-small cell lung cancer (NSCLC) compared with para-carcinoma tissues. JMJD1A knockdown significantly inhibited NSCLC cell growth, migration, and invasion in vitro and tumorigenesis in vivo. [Tumor Biol] Abstract MicroRNA-183 Promotes Migration and Invasion of CD133+/CD326+ Lung Adenocarcinoma Initiating Cells via PTPN4 Inhibition Researchers explored the regulation of protein tyrosine phosphatase non-receptor type 4 (PTPN4) by miR-183 in vitro using luciferase reporter assays, and they further analyzed the effects of miR-183 on the invasiveness of cancer stem-like cells in vitro and in vivo using transwell and bioluminescence assays. [Tumor Biol] Abstract Hyperoside Induces both Autophagy and Apoptosis in Non-Small Cell Lung Cancer Cells In Vitro Researchers investigated whether autophagy was involved in the anticancer mechanisms of hyperoside in human non-small cell lung cancer cells in vitro. [Acta Pharmacol Sin] Abstract |