Pulmonary Cell News Volume 5.21 | Jun 2 2016

TOP STORY

Dual Targeting of PI3K and MEK Enhances the Radiation Response of K-RAS Mutated Non-Small Cell Lung Cancer

Scientists investigated if targeting PI3K would be a potential approach for enhancing the radiosensitivity of K-RAS mutated non-small cell lung cancer cell lines A549 and H460. [Oncotarget] Full Article

(Ranked by impact factor of the journal)

Efficient Suilysin-Mediated Invasion and Apoptosis in Porcine Respiratory Epithelial Cells after Streptococcal Infection under Air-Liquid Interface Conditions

Scientists established porcine respiratory air-liquid interface cultures from the porcine lung to analyze the interaction of streptococci with their primary target cells. [Sci Rep] Full Article

Impaired Airway Epithelial Cell Responses from Children with Asthma to Rhinoviral Infection

Investigators explored the relationship between apoptotic, innate immune and inflammatory responses to human rhinovirus infection in airway epithelial cells obtained from children with asthma and non-asthmatic controls. [Clin Exp Allergy] Abstract

Azithromycin Differentially Affects the IL-13-Induced Expression Profile in Human Bronchial Epithelial Cells

The authors hypothesized that azithromycin differentially affects the interleukin (IL)-13-induced expression profile. To investigate this, they focused on IL-13-induced mucin and T helper 2-signature expression in human bronchial epithelial cells and how this combined expression profile is affected by azithromycin treatment. [Pulm Pharmacol Ther] Abstract

Haplotype and Diplotype Analyses of Variation in ERCC5 Transcription Cis-Regulation in Normal Bronchial Epithelial Cells

Haplotype and diplotype analyses were conducted in normal bronchial epithelial cells to better understand mechanisms responsible for inter-individual variation in transcript abundance regulation of excision repair cross-complementation group 5 (ERCC5). [Physiol Genomics] Abstract

Epigenetic Dysregulation of Interleukin 8 (CXCL8) Hypersecretion in Cystic Fibrosis Airway Epithelial Cells

Scientists showed abnormal epigenetic regulation is responsible for CXCL8 overexpression in cystic fibrosis (CF) cells. Under basal conditions CF cells had increased bromodomain (Brd)3 and Brd4 recruitment and enhanced nuclear factor-κB and CCAAT/enhancer binding protein β binding to the CXCL8 promoter compared to non-CF cells due to trimethylation of histone H3 at lysine 4 and DNA hypomethylation at CpG6. [Biochem Biophys Res Commun] Abstract

LUNG CANCER

Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway

The authors isolated stellettin B from marine sponge Jaspis stellifera, and demonstrated that it induced G1 arrest, apoptosis and autophagy at low concentrations in human non-small cell lung cancer A549 cells. [Sci Rep] Full Article

miR-134 Inhibits Non-Small Cell Lung Cancer Growth by Targeting the Epidermal Growth Factor Receptor

Researchers identified a novel epidermal growth factor receptor (EGFR)-targeting microRNA (miRNA), miRNA-134 (miR-134), in non-small-cell lung cancer (NSCLC) cell lines. In addition, the overexpression of miR-134 inhibited EGFR-related signaling and suppressed NSCLC cells proliferation by inducing cell cycle arrest and/or apoptosis, suggesting that miR-134 functions as a tumor suppressor in NSCLC. [J Cell Mol Med] Abstract

Dickkopf-1-Promoted Vasculogenic Mimicry in Non-Small Cell Lung Cancer Is Associated with EMT and Development of a Cancer Stem-Like Cell Phenotype

To characterize the contributions of Dickkopf-1 towards the induction of vasculogenic mimicry in non-small cell lung cancer, researchers evaluated cohorts of primary tumors, performed in vitro functional studies and generated xenograft mouse models. [J Cell Mol Med] Abstract

Bufalin Derivative BF211 Inhibits Proteasome Activity in Human Lung Cancer Cells In Vitro by Inhibiting β1 Subunit Expression and Disrupting Proteasome Assembly

A549 human lung cancer cells were treated with BF211. A SILAC-based proteomic analysis was used to detect the protein expression profiles of BF211-treated A549 cells. [Acta Pharmacol Sin] Abstract

Polarized Airway Epithelial Models for Immunological Co-Culture Studies

The authors focus on current knowledge and the advantages and limitations of the different cell types and culture methods used in co-culture models of the human airways. [Int Arch Allergy Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

PSI NSCLC Abstract at ASCO 2016

PSI CRO announced that PSI’s scientific expertise is represented with an abstract publication. The published abstract, Co-Morbidity in Clinical Trial Patients with Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC), is authored by PSI’s Medical Affairs Department and is based on more than a decade of experience that PSI has gathered running global studies in advanced or metastatic non-small cell lung cancer. [Press release from PSI CRO (Business Wire) discussing research presented at 2016 American Society of Clinical Oncology (ASCO) Annual Meeting, Chicago] Press Release

Boehringer Ingelheim and Inventiva Collaborate to Develop Potential New Treatments for Idiopathic Pulmonary Fibrosis

Boehringer Ingelheim and Inventiva announced a new multi-year research and drug discovery collaboration and licensing agreement. Under the terms of the agreement, the Inventiva and Boehringer Ingelheim research teams will jointly validate a new therapeutic concept with the aim of discovering new medicines for the treatment of Idiopathic Pulmonary Fibrosis and other fibrotic diseases. [Boehringer Ingelheim GmbH] Press Release

ARIAD Announces Initiation of Phase I/II Clinical Trial of AP32788, an Investigational Oral Inhibitor of EGFR and HER2, in Patients with Non-Small Cell Lung Cancer

ARIAD Pharmaceuticals, Inc. announced initiation of the Phase I/II clinical trial of AP32788, an investigational tyrosine kinase inhibitor designed as a targeted therapy for patients with non-small cell lung cancer with specific mutations in EGFR or HER2. [ARIAD Pharmaceuticals, Inc.] Press Release

Daiichi Sankyo Provides Update on HER3-Lung Study of Patritumab in Non-Small Cell Lung Cancer (NSCLC)

Daiichi Sankyo Company, Limited announced that the two-part Phase III HER3-Lung study of patritumab will not proceed into the second part. This decision followed the recommendation of an independent data monitoring committee that concluded that the first part of the study did not meet the pre-defined efficacy criteria required to proceed with Part B of the study. [Daiichi Sankyo Company, Limited] Press Release

NEW From Stem Cells to Human Development
September 25-28, 2016
Southbridge, United States

Visit our events page to see a complete list of events in the pulmonary cell community.

NEW Postdoctoral Fellow – Cancer Immunology and Immunotherapy (Oslo University Hospital)

NEW Postdoctoral Fellow – Vascular/Lung Biology (Yale University School of Medicine)

Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Lung Cancer (German Cancer Research Center)

Postdoctoral Position – Lung Alveolar Epithelial Cell Biology/Differentiation (University of Southern California)

Postdoctoral Researcher – Biochemistry/Molecular Biology (National Jewish Health)

Postdoctoral Fellow – Immunology (New York University Medical Center)

Postdoctoral Fellow – Lung Disease (Oklahoma State University)

Postdoctoral Fellow – Cell Biology (University of Chicago)

Faculty Positions – Basic or Translational Research (Cleveland Clinic)

Postdoctoral Position or Research Scientist – Mucosal Immunology (Qu Biologics)

Director Clinical Research – Medical Oncology (Fred Hutchinson Cancer Research Center)

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