Pulmonary Cell News Volume 6.37 | Sep 21 2017

TOP STORY

Neutrophil Transfer of miR-223 to Lung Epithelial Cells Dampens Acute Lung Injury in Mice

Researchers hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial cells could alter mucosal gene expression during acute lung injury. Pulmonary-epithelial microRNA profiling during coculture of alveolar epithelial cells with polymorphonuclear neutrophils revealed a selective increase in lung epithelial cell expression of miR-223. [Sci Transl Med] Abstract

(Ranked by impact factor of the journal)

Attenuated PDGF Signaling Drives Alveolar and Microvascular Defects in Neonatal Chronic Lung Disease

The authors discovered significant enrichment for single nucleotide polymorphisms in the platelet‐derived growth factor (PDGF)-Rα gene in preterms with neonatal chronic lung disease (nCLD) and directly tested the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of mechanical ventilation with O₂. [EMBO Mol Med] Full Article | Graphical Abstract

Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma

Scientists developed a novel in vitro platform that mimics the micro/nano-scale architecture of the alveolar microenvironment and used this system to investigate how extracelluar matrix microstructural properties influence epithelial cell injury during airway reopening. [Sci Rep] Full Article

Targeting HIF-1α/PDK1 Axis by Dichloroacetate (DCA) Suppresses Bleomycin-induced Pulmonary Fibrosis

Bleomycin-induced pulmonary fibrotic progression was evaluated in two independent fibroblast-specific promoter-driven Hif1A knockout mouse models and in glycolytic inhibitor DCA-treated mice. Genetic and pharmacological approaches were used to explicate the role of metabolic reprogramming in myofibroblast differentiation. [Am J Respir Cell Mol Biol] Abstract

A Comparison of Drug Transport in Pulmonary Absorption Models: Isolated Perfused Rat Lungs, Respiratory Epithelial Cell Lines and Primary Cell Culture

Investigators evaluated the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. The permeability of seven compounds selected to possess a range of lipophilicity was measured in two airway cell lines, in normal human bronchial epithelial cells and using a simple IPL technique. [Pharm Res] Full Article

Expression of Surfactant Protein B Is Dependent on Cell Density in H441 Lung Epithelial Cells

The authors investigated the impact of cell-cell contact on surfactant protein (SP)-B mRNA and mature SP-B expression in the lung epithelial cell line H441. [PLoS One] Full Article

LUNG CANCER

MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway

Scientists report the identification of a lncRNA signature associated with metastasis of non-small cell lung cancer (NSCLC). Elevated expression of LINC00963 (MetaLnc9) in human NSCLC specimens correlated with poor prognosis, promoted migration and invasion of NSCLC cells in vitro, and enhanced lung metastasis formation in vivo. [Cancer Res] Abstract

The RNA-Editing Enzyme ADAR Promotes Lung Adenocarcinoma Migration and Invasion by Stabilizing FAK

Researchers found that the RNA-editing protein adenosine deaminase acting on double-stranded RNA (ADAR) acted as a facilitator of lung adenocarcinoma progression through its ability to stabilize transcripts encoding focal adhesion kinase (FAK). [Sci Signal] Full Article

Suppression of TGF-β1 Enhances Chemosensitivity of Cisplatin-Resistant Lung Cancer Cells Through the Inhibition of Drug-Resistant Proteins

Investigators showed significant positive correlation between the expression of ERCCl and vimentin, and significant negative correlation between the ERCCl and E-cadherin in the neoadjuvant chemotherapy group and the simple surgery group. They showed that cisplatin-resistant A549 cells acquire epithelial–mesenchymal transition phenotype with high expression of drug-resistant proteins, P-gp and ERCC1. [Artif Cells Nanomed Biotechnol] Abstract

Novel Carbonic Anhydrase IX-Targeted Therapy Enhances the Anti-Tumor Effects of Cisplatin in Small Cell Lung Cancer

The authors assessed the potential of carbonic anhydrase IX inhibition using 4-(3′-(3″,5″-dimethylphenyl)ureido)phenyl sulfamate, for the treatment of human small cell lung cancer alone and in combination with cisplatin chemotherapy. [Int J Cancer] Abstract

A Diphenyldiselenide Derivative Induces Autophagy via JNK in HTB-54 Lung Cancer Cells

Researchers evaluated in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide scaffold. Most of the compounds exhibited high efficacy for inducing cytotoxicity against different human cancer cell lines. [J Cell Mol Med] Abstract

Histone Code and Long Non-Coding RNAs (lncRNAs) Aberrations in Lung Cancer: Implications in the Therapy Response

Scientists offer a systematic revision of the current knowledge about the major epigenetic aberrations represented by changes in histone post-translational modifications and lncRNAs expression levels and patterns in human lung carcinomas in cancer drug-based treatments, as an important comprehensive knowledge focusing on better oncological therapies. [Clin Epigenetics] Full Article

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FDA Approves Amgen and Allergan’s MVASI^™ (bevacizumab-awwb) for the Treatment of Five Types of Cancer

Amgen and Allergan plc. announced that the FDA has approved MVASI^™ for all eligible indications of the reference product, Avastin^®. MVASI is the first anti-cancer biosimilar, as well as the first bevacizumab biosimilar, approved by the FDA. [Amgen Inc.] Press Release

Theravance Biopharma Highlights Approval of Trelegy Ellipta (Closed Triple) as the First Once-Daily Single Inhaler Triple Therapy for the Treatment of Appropriate Patients with COPD in the US

Theravance Biopharma, Inc. highlighted that the FDA has approved Trelegy Ellipta, the triple combination therapy of fluticasone furoate, umeclidinium, and vilanterol in a single ELLIPTA^® inhaler, for the long-term, once-daily, maintenance treatment of appropriate patients with COPD. [Theravance Biopharma] Press Release

STEMCELL Technologies Signs Exclusive License with Propagenix to Commercialize EpiX^™, an Innovation Empowering Epithelial Cell Biology and Cell Therapy

STEMCELL Technologies has signed an exclusive license with Propagenix to commercialize its patented EpiX^™ technology, a novel and revolutionary cell culture medium that enables unprecedented expansion of tissue-resident epithelial stem cells without any genetic manipulation. [STEMCELL Technologies Inc.] Press Release

U.S. House Approves 2018 Spending Bills, but Process Far from Finished

The U.S. House of Representatives took a major step toward setting federal science budgets for the 2018 fiscal year. But Congress is still far from the finish line, and final spending levels aren’t likely to be finalized until late this year at the earliest. [ScienceInsider] Editorial

Publishers Go After Networking Site for Illicit Sharing of Journal

A major scientific publishing group is taking aim at a social networking site for allowing researchers to illegally post copies of their journal papers. The International Association of Scientific, Technical, and Medical Publishers in Oxford, U.K., and The Hague, the Netherlands, has written to ResearchGate, a networking website for researchers, to express concerns over its article-sharing practices. [ScienceInsider] Editorial

NEW 58^th Annual Meeting of the Japanese Respiratory Society
April 27-29, 2018
Osaka, Japan

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NEW Research Scientist – Lung Cancer Models (The Francis Crick Institute)

Postdoctoral Fellow – Non-Small-Cell-Lung-Cancer (University of Gothenburg)

PhD Position(s) – Cancer Biology (VIB-KULEUVEN Center for Cancer Biology)

Faculty Position(s) – Basic and Translational Cancer Research (Texas Tech University Health Science Center)

Faculty Positions – Lung Injury/Repair and Pulmonary Infectious Diseases (University of Texas Health Science Center at Tyler)

Postdoctoral Fellow – Pulmonary Fibrosis (University of Michigan)

Postdoctoral Research Fellow – Pathobiology of Fibrotic Lung Diseases (Cincinnati Children’s Hospital)

Postdoctoral Fellow – Childhood Cardiovascular and Pulmonary Diseases (University of Colorado Anschutz Medical Campus)

Physician Scientist or Senior Scientist – Pulmonary and Critical Care Medicine (Brigham and Women’s Hospital)

Postdoctoral Fellow – Pulmonary Research (University of Maryland)

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