Pulmonary Cell News Volume 7.26 | Jul 5 2018

TOP STORY

Rocaglamide Enhances NK Cell-Mediated Killing of Non-Small Cell Lung Cancer Cells by Inhibiting Autophagy

Investigators showed that the natural product rocaglamide enhanced natural killer cell-mediated lysis of non-small cell lung cancer cells in vitro and tumor regression in vivo. [Autophagy] Abstract

(Ranked by impact factor of the journal)

Host Lipidome Analysis during Rhinovirus Replication in Human Bronchial Epithelial Cells Identifies Potential Therapeutic Targets

Scientists performed unbiased lipidomic analysis on human bronchial epithelial cells infected over a six hour period with the RV-A1b strain of rhinovirus to determine changes in 493 distinct lipid species. [J Lipid Res] Abstract | Full Article

Concurrence of Autophagy with Apoptosis in Alveolar Epithelial Cells Contributes to Chronic Pulmonary Toxicity Induced by Methamphetamine

In alveolar epithelial cells, the autophagy marker LC3 and percent of cells containing LC3-positive autophagosome were significantly increased. [Cell Prolif] Abstract

Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-Guided Cell Repair

Investigators examined the mechanisms of exogenous TRIM72 protein (rhT72)-mediated lung cell protection in vitro and tested the efficacy of inhaled rhT72 in reducing tissue pathology in a mouse model of ventilator-induced lung injury. [Am J Respir Cell Mol Biol] Abstract

Influenza Virus Infection Modulates the Death Receptor Pathway during Early Stages of Infection in Human Bronchial Epithelial Cells

The authors investigated the gene expression profiles of influenza A virus-infected versus mock-infected cells at the early stage of infection using a PCR array for death receptor pathway. [Physiol Genomics] Abstract

LUNG CANCER

EZH2-Mediated Epigenetic Suppression of GDF15 Predicts a Poor Prognosis and Regulates Cell Proliferation in Non-Small-Cell Lung Cancer

Researchers found that growth differentiation factor 15 (GDF15) was downregulated in paired non-small-cell lung cancer (NSCLC) tissues and correlated with poor clinical outcomes in NSCLC. A functional experiment demonstrated that overexpression of GDF15 significantly repressed NSCLC proliferation both in vitro and in vivo. [Mol Ther Nucleic Acids] Full Article

Hydrogen Peroxide Inhibits the Growth of Lung Cancer Cells via the Induction of Cell Death and G1-Phase Arrest

The authors investigated the molecular and cellular effects of exogenous hydrogen peroxide (H₂O₂) on Calu-6 and A549 lung cancer cells. Based on MTT assays, H₂O₂ inhibited the growth of Calu-6 and A549 cells with IC50 values of ~50 and 100 µM at 24 hours, respectively. [Oncol Rep] Abstract

Suppression of Cleavage Factor Im 25 Promotes the Proliferation of Lung Cancer Cells through Alternative Polyadenylation

The transcript levels of cyclinD1 and GSK3β were significantly increased and the distal PAS usage of several oncogenes were decreased after cleavage factor Im 25 knockdown. [Biochem Biophys Res Commun] Abstract

lincROR Influences the Stemness and Crizotinib Resistance in EML-ALK⁺ Non-Small-Cell Lung Cancer Cells

Scientists investigated the expression profile of long intergenic noncoding RNA, regulator of reprogramming (lincROR) in Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML-ALK) non-small-cell lung cancer tissues, and the potential role of lincROR in prognosis was then analyzed. [Onco Targets Ther] Full Article

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Immune Checkpoint Inhibitors in Early-Stage and Locally Advanced Non-Small Cell Lung Cancer

The authors provide an overview of the emerging data on the role of programed cell death-1/programmed cell death ligand 1 and cytotoxic T lymphocyte-associated protein 4 inhibitors in the treatment of early-stage and locally advanced non-small cell lung cancer, with a focus on ongoing clinical trials and combination strategies. [Curr Treat Options Oncol] Abstract

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OSE Immunotherapeutics Receives IDMC Approval to Continue “Atalante 1” Phase III NSCLC Clinical Trial of Tedopi^®

OSE Immunotherapeutics SA received approval from the Independent Data Monitoring Committee (IDMC) to continue Atalante 1, the company’s international pivotal Phase III clinical study of Tedopi^® for the treatment of Non-Small Cell Lung Cancer (NSCLC) following immune checkpoint inhibitor treatment. [OSE Immunotherapeutics SA] Press Release

Oncodesign Announces the Results of the Second Stage of Its Clinical Study in Lung Cancer

Oncodesign announced the results of the second stage of its Phase I clinical study assessing the first radiotracer resulting from its Nanocyclix^® technology. [Oncodesign] Press Release

BioAtla Announces First Patient Treated in Phase I/II BA3021-001 Clinical Trial for CAB-ROR2-ADC Therapeutic

BioAtla, LLC announced the treatment of the first patient in its clinical trial BA3021-001 for BioAtla’s BA3021, a novel conditionally active ROR2-targeted antibody-drug conjugate. [BioAtla, LLC (PR Newswire Association LLC.)] Press Release

FDA Grants Priority Review to Merck’s Supplemental Biologics License Application for KEYTRUDA^® (Pembrolizumab) in Combination with Chemotherapy as First-Line Treatment for Metastatic Squamous Non-Small Cell Lung Cancer

Merck announced that the FDA has accepted for review a supplemental Biologics License Application for KEYTRUDA, Merck’s anti-PD-1 therapy, in combination with carboplatin-paclitaxel or nab-paclitaxel as a first-line treatment for metastatic squamous non-small cell lung cancer, regardless of PD-L1 expression. [Merck & Co., Inc.] Press Release

Hidden Conflicts? Pharma Payments to FDA Advisers after Drug Approvals Spark Ethical Concerns

In examining compensation records from drug companies to physicians who advised FDA on whether to approve 28 psychopharmacologic, arthritis, and cardiac or renal drugs between 2008 and 2014, Science found widespread after-the-fact payments or research support to panel members. The agency’s safeguards against potential conflicts of interest are not designed to prevent such future financial ties. [ScienceInsider] Editorial

Hungarian Academy to Draw Up Alternative Research Budget

The Hungarian Academy of Sciences is set to put forward an “alternative proposal” for the country’s research budget, after the government moved to put the Ministry of Innovation and Technology in charge of financing research institutions, seen as the latest attack on sector autonomy by the authoritarian Orbán administration. [Times Higher Education] Editorial

University of Gothenburg Moves to Fire Professor for Misconduct

The University of Gothenburg has taken steps to remove Suchitra Sumitran-Holgersson from her post as a professor there, after an investigation concluded that she manipulated images in seven out of ten papers. [The Scientist] Editorial

Geneticist Francisco Ayala Quits after Sexual Harassment Accusations

The University of California, Irvine, which found him guilty of inappropriate behavior, will remove Ayala’s name from buildings and scholarships. [The Scientist] Editorial

NEW 2018 National Cancer Research Institute (NCRI) Cancer Conference
November 4-6, 2018
Glasgow, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Bioengineer – Infection and Immunity in Human Organoids (Charité)

Research Technologist – Pulmonary (STEMCELL Technologies Inc.)

Postdoctoral Associate – Chemotherapy and Radiation Therapy (Baylor College of Medicine)

Postdoctoral Researcher – Lung Cancer (University of Oxford)

Principal Investigators – Cancer (University of Alabama Birmingham)

Chief – Integrative Tumor Epidemiology Branch (National Institutes of Health – National Cancer Institute)

Postdoctoral Position – Immunology/Molecular Biology (National Heart, Lung and Blood Institute)

Postdoctoral Position – Vascular or Lung Biology (Yale University School of Medicine)

Postdoctoral Fellow – Human Lung Stem Cells and Regeneration (MedImmune)

Postdoctoral Fellow – Virology and Respiratory Biology (MedImmune)

Assistant or Associate Professor – Genetic Epidemiology (University of Kentucky)

Postdoctoral Scholarship – Cancer Metabolism (Karolinska Institutet)

Postdoctoral Fellow – Immunology (NYU Langone Health)

PhD Student – Novel Concepts for Therapy of Allergy (Helmholtz Zentrum München)

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