Pulmonary Cell News Volume 7.27 | Jul 12 2018

TOP STORY

NOTCH3 Contributes to Rhinovirus-Induced Goblet Cell Hyperplasia in COPD Airway Epithelial Cells

Mucociliary-differentiated chronic obstructive pulmonary disease (COPD) and normal airway epithelial cell cultures and mice with normal or COPD phenotype were infected with rhinovirus or sham and examined for goblet cell hyperplasia by immunofluorescence and/or mucin gene expression. [Thorax] Abstract

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Cigarette Smoke Extract Enhances Neutrophil Elastase-Induced IL-8 Production via Proteinase-Activated Receptor-2 Upregulation in Human Bronchial Epithelial Cells

Researchers elucidated the effect of cigarette smoke extract on the neutrophil elastase-induced inflammatory response and its molecular mechanism in bronchial epithelial cells. [Exp Mol Med] Full Article

Curcumin Attenuates Airway Inflammation and Airway Remolding by Inhibiting NF-κB Signaling and COX-2 in Cigarette Smoke-Induced COPD Mice

The authors evaluated the therapeutic effects of curcumin on airway inflammation using lipopolysaccharide (LPS) and cigarette smoke-induced chronic obstructive pulmonary disease (COPD) murine models and LPS-stimulated human bronchial epithelial cells. [Inflammation] Abstract

Astragaloside IV Inhibits Cigarette Smoke-Induced Pulmonary Inflammation in Mice

Researchers investigated the effects of Astragaloside IV on cigarette smoke-induced chronic obstructive pulmonary disease. [Inflammation] Abstract

LUNG CANCER

Epigenetically Regulated PAX6 Drives Cancer Cells toward a Stem-Like State via GLI-SOX2 Signaling Axis in Lung Adenocarcinoma

Scientists demonstrated that PAX6 acts as an oncogene responsible for induction of cancer stemness properties in lung adenocarcinoma. Mechanistically, PAX6 promoted GLI transcription, resulting in SOX2 upregulation directly by the binding of GLI to the proximal promoter region of the SOX2 gene. [Oncogene] Abstract

CTEN Induces Epithelial-Mesenchymal Transition (EMT) and Metastasis in Non Small Cell Lung Cancer Cells

Investigators explored the effects and mechanism of CTEN (COOH-terminus tensin-like molecule) on EMT, cell migration and invasion of human lung adenocarcinoma cells. [PLoS One] Full Article

VEGFC/VEGFR3 Axis Mediates TGFβ1-Induced Epithelial-to-Mesenchymal Transition in Non-Small Cell Lung Cancer Cells

Researchers found that short term transforming growth factor β1 (TGFβ1) treatment resulted in a significant epithelial-mesenchymal transition morphological change in TGFβ1-sensitive non-small cell lung cancer cells but not in insensitive cells. [PLoS One] Full Article

Wogonoside Induces Apoptosis in Human Non-Small Cell Lung Cancer A549 Cells by Promoting Mitochondria Dysfunction

Scientists determined the anti-tumor effect of wogonoside in human NSCLC A549 cells. They found that wogonoside effectively inhibited A549 cell viability through inducing cell cycle arrest and apoptosis. [Biomed Pharmacother] Abstract

CircRNA Circ-BANP-Mediated miR-503/LARP1 Signaling Contributes to Lung Cancer Progression

The authors found circular RNA (circ)-BANP was overexpressed in lung cancer tissues. Higher circ-BANP expression was associated with lower survival rate. Moreover, silencing circ-BANP markedly inhibited proliferation, migration and invasion of lung cancer cells in vitro and impaired tumor propagation in vivo. [Biochem Biophys Res Commun] Abstract

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Alpha-1 Antitrypsin Deficiency: Outstanding Questions and Future Directions

Alpha-1 antitrypsin deficiency is a rare hereditary condition that leads to decreased circulating alpha-1 antitrypsin levels, significantly increasing the risk of serious lung and/or liver disease in children and adults, in which some aspects remain unresolved. [Orphanet J Rare Dis] Full Article

Visit our reviews page to see a complete list of reviews in the pulmonary cell research field.

MedImmune and 4D Molecular Therapeutics Collaborate to Design, Develop and Commercialize AAV Gene Therapy for Chronic Lung Disease

MedImmune and 4D Molecular Therapeutics announced a collaboration to develop and commercialize a gene therapeutic for patients with chronic lung disease, utilizing 4DMT’s novel discovery platform to generate optimized adeno-associated virus (AAV) vectors. [MedImmune] Press Release

Asterias Biotherapeutics Announces Positive Outcome from Safety Review Committee for AST-VAC2; Recommends Continuation of Clinical Trial in Non-Small Cell Lung Cancer (NSCLC)

Asterias Biotherapeutics, Inc. announced that the Safety Review Committee for the first clinical trial of AST-VAC2, held a scheduled meeting to review the safety and tolerability data generated in the first patient enrolled in the study and recommended continuation of the study and moving to parallel enrollment of the second and third patients in the advanced cancer cohort, as planned per the study’s protocol. [Asterias Biotherapeutics, Inc.] Press Release

Kamada Receives Positive Scientific Advice from European Medicines Agency on a New Phase III Study Design for Inhaled AAT

Kamada Ltd. announced that it has received positive scientific advice from the Committee for Medicinal Products for Human Use of the European Medicines Agency related to the development plan for its proposed pivotal Phase III study for its proprietary Inhaled Alpha-1 Antitrypsin therapy for the treatment of alpha-1 antitrypsin deficiency. [Kamada Ltd.] Press Release

Galapagos Announces Design for PINTA Phase II Trial with GLPG1205 in IPF

Galapagos NV announced the PINTA Phase II trial design with its GPR84 inhibitor GLPG1205 in patients with idiopathic pulmonary fibrosis (IPF). [Galapagos NV] Press Release

It’s Time to Burst the Biomedical Bubble in UK Research

A new study calls for a rebalancing of research and innovation funding to better meet the UK’s economic, social and health needs. [The Guardian] Editorial

Chinese Researchers to Get More Autonomy Over Lab Spending

Chinese Premier Li Keqiang says the country will ease restrictive rules governing how research funds are used, and cut red tape for researchers. Revised rules are designed to help researchers focus on their work and compete with their counterparts globally. [Nature News] Editorial

UK Universities Fall Short on Reporting Misconduct Investigations

The United Kingdom should establish a committee to monitor efforts by the nation’s universities to properly conduct misconduct investigations, a parliamentary inquiry recommends. The guidance follows a new report released on 11 July, revealing that one in four UK universities does not comply with research integrity guidelines released six years ago. [Nature News] Editorial

NEW American College of Allergy, Asthma, & Immunology (ACAAI) 2018 Annual Scientific Meeting
November 15-19, 2018
Seattle, Washington, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Lung and Vascular Diseases (Icahn School of Medicine at Mount Sinai)

NEW Postdoctoral Fellow – Cellular Therapeutics in Chronic Lung Disease (Helmholtz Zentrum München)

Bioengineer – Infection and Immunity in Human Organoids (Charité)

Postdoctoral Associate – Chemotherapy and Radiation Therapy (Baylor College of Medicine)

Postdoctoral Researcher – Lung Cancer (University of Oxford)

Principal Investigators – Cancer (University of Alabama Birmingham)

Chief – Integrative Tumor Epidemiology Branch (National Institutes of Health – National Cancer Institute)

Postdoctoral Position – Immunology/Molecular Biology (National Heart, Lung and Blood Institute)

Postdoctoral Position – Vascular or Lung Biology (Yale University School of Medicine)

Postdoctoral Fellow – Human Lung Stem Cells and Regeneration (MedImmune)

Postdoctoral Fellow – Virology and Respiratory Biology (MedImmune)

Assistant or Associate Professor – Genetic Epidemiology (University of Kentucky)

Postdoctoral Fellow – Immunology (NYU Langone Health)

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