Pulmonary Cell News 7.35 September 6, 2018 | |
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TOP STORYPath to a Targeted Treatment for Small-Cell Lung Cancer? Scientists at Fred Hutchinson Cancer Research Center revealed how losing a specific gene – which happens in about 15 percent of small-cell lung cancer patients – accelerated tumor formation in mice. And, most exciting to the researchers, these tumors seemed to be uniquely sensitive to a specific drug, which dramatically shrunk some tumors in mice with the mutation. [Press release from the Fred Hutchinson Cancer Research Center discussing online prepublication in Cancer Discov] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Regulation of Human Airway Epithelial Tissue Stem Cell Differentiation by β-Catenin, P300, and CBP Researchers reported that human bronchiolar tissue stem cell differentiation to mucus and ciliated cells could be divided into two stages, specification and commitment. A β-catenin/E1A-binding protein (P300) complex promoted mucus cell specification and β-catenin interacted with either P300 or cAMP response element binding protein (CBP) to inhibit ciliated cell commitment. [Stem Cells] Abstract Investigators observed normal lung development at the time of birth in mice lacking E-cadherin in the lung epithelium. E-cadherin deficiency led to progressive epithelial damage in mice growing into adulthood, as evidenced by airway epithelial denudation, decreased zonula occludens-1 expression, loss of ciliated cells, and enlarged alveolar spaces. [Sci Rep] Full Article miR-301a was found to be upregulated during arsenic-induced BEAS-2B transformation and the overexpression of miR-301a was dependent on IL-6/STAT3 signaling. SMAD4 was confirmed to be a direct target of miR-301a in BEAS-2B cells and upregulation of SMAD4 was involved the restraining cell growth and migration. [Sci Rep] Full Article Scientists demonstrated that interrupted reprogramming resulted in controlled expansion of cell numbers yet preservation of the differentiation pathway to the alveolar epithelial lineage. When transplanted to the injured lungs, alveolar epithelial type II-induced progenitor-like cells were retained in the lung and ameliorated bleomycin-induced pulmonary fibrosis. [NPJ Regen Med] Full Article LUNG CANCERGap junction beta-4 protein (Gjb4) activated Src signaling via MET, and overexpression of Gjb4 enhanced sphere-forming ability and anchorage-independent growth, which were reversed by inhibition of Src. Investigators demonstrated that Gjb4-mediated Src activation enhanced chemoresistance of cancer cells toward gemcitabine and etoposide. [Oncogene] Abstract Scientists demonstrated that genetic silencing of TWIST1 or treatment with the TWIST1 inhibitor, harmine, resulted in growth inhibition and apoptosis in EGFR-mutant non-small-cell lung cancer. Genetic and pharmacological inhibition of TWIST1 in EGFR tyrosine kinase inhibitor (TKI)-resistant EGFR-mutant cells increased sensitivity to EGFR TKIs. [Oncogene] Abstract miR-409 Inhibits Human Non-Small Cell Lung Cancer Progression by Directly Targeting SPIN1 The authors revealed that miR-409 inhibited the expression of Spindlin 1 (SPIN1) through binding directly to the 3′-untranslated region of SPIN1. Overexpression of miR-409 significantly suppressed cell migration, growth and proliferation by inhibiting SPIN1 in vitro and in vivo. [Mol Ther Nucleic Acids] Full Article External qi of Yan Xin Qigong (YXQ-EQ) induced apoptosis in A549 cells, resulting in a pronounced reduction in viability and clonogenic formation. This was associated with inhibition of phosphorylation of AKT and ERK1/2 and reduced expression of anti-apoptotic proteins BCL-xL, XIAP and survivin. [Cell Physiol Biochem] Full Article Increased apoptosis, reduction of tumor volume, and inhibition of MAPK and PI3K/AKT signaling molecules for proliferation and survival were observed when three kinases (Src, MET, and ALK) were inhibited. A patient-derived xenograft from alectinib-resistant cells indicated that combination therapy with saracatinib and crizotinib significantly decreased tumor size in vivo. [Mol Cancer Res] Abstract CircRNA hsa_circ_100395 Regulates miR-1228/TCF21 Pathway to Inhibit Lung Cancer Progression Researchers showed that hsa_circ_100395 served as a sponge for miR-1228 targeting TCF21 in lung cancer. Rescue assays indicated that hsa_circ_100395 regulated lung cancer cell proliferation, migration and invasion through modulating miR-1228/TCF21 pathway. [Cell Cycle] Abstract Subscribe to one of our other 19 science newsletters such as Intestinal Cell News & Human Immunology News. | |
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REVIEWSThe authors summarize findings that highlight the role of dimensions of chronic obstructive pulmonary disorder in the investigation of oxidative stress, inflammatory responses, genetic and epigenetic studies, and pharmacological and dietary antioxidant intervention. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the pulmonary cell research field. | |
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INDUSTRY NEWSVium, Inc. announced it will collaborate with 3Scan, Inc. to quantify lung and liver disease to improve preclinical research. [Vium, Inc.] Press Release Vertex Pharmaceuticals Incorporated announced that enrollment is complete for the two Phase III studies of the next-generation corrector VX-659 in triple combination with tezacaftor and ivacaftor in people with cystic fibrosis with one F508del mutation and one minimal function mutation and in people with two F508del mutations. [Vertex Pharmaceuticals Incorporated] Press Release Merrimack Pharmaceuticals, Inc. announced that it has completed enrollment in its ongoing SHERLOC study, a Phase 2 clinical trial evaluating its lead investigational drug candidate, MM-121, in patients with heregulin positive NSCLC. [Merrimack Pharmaceuticals, Inc.] Press Release TESARO, Inc. announced that it has initiated the second stage of the JASPER study that is designed to assess clinical benefit of ZEJULA® in combination with an anti-PD-1 antibody in first-line non-small cell lung cancer patients. [TESARO, Inc.] Press Release | |
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POLICY NEWSSouth Africa Pushes Science to Improve Daily Life South Africa’s science system is set for its biggest shake-up in 20 years, amid proposed legislation changes that aim to make research efforts better serve citizens and address problems such as poverty and unemployment. It also reaffirms a key government goal to boost total research and development spending from 0.8% to 1.5% of gross domestic product in the next decade. [Nature News] Editorial AACR Apologizes for Delays in Retracting Papers The American Association for Cancer Research (AACR) has issued retractions, corrections, or editor’s notes for a handful papers across five of its journals and is sorry for the time it’s taken to do so, according to a statement published in Cancer Research. [The Scientist] Editorial Google Unveils Search Engine for Open Data Google has unveiled a search engine to help researchers locate online data that is freely available for use. The company launched the service, saying that it is aimed at “scientists, data journalists, data geeks, or anyone else”. [Nature News] Editorial UK ‘Missing Out’ on Overseas Students University leaders are calling for changes to the UK visa system to allow international students to stay and work for two years after they graduate. Universities UK says otherwise overseas students, worth £26bn to the UK economy, will opt for countries such as the US, Canada and Australia. [The BBC] Editorial
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EVENTSNEW Cell Symposia: Engineering Organoids and Organs Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scientist – Cancer Biology and Immunology (Technical University of Munich) Postdoctoral Research Fellow – Respiratory Epithelial Cell Biology (STEMCELL Technologies Inc.) PhD Students – Lung Disease Research (Justus-Liebig-Universität Gießen) Faculty Investigators – Cancer Research (The University of Alabama at Birmingham) Postdoctoral Position – Lung Diseases (German Research Center for Environmental Health) Postdoctoral Position – Acute Lung Injury (University of Kentucky) Cancer Research Scholar – Lung Cancer (University of California) Principal Investigators – Cancer (University of Alabama Birmingham) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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